Surgery in recurrent ovarian cancer

Ovarian cancer is one of the most challenging diseases in gynecologic oncology. The presentation of frequent recurrences requires the establishment and further development of therapy standards for this patient group. Surgery is crucial in the therapy of patients with primary ovarian cancer, and the postoperative residual tumor mass is the most relevant clinical prognostic factor. The surgical management of recurrent disease is still subject to an emotional international discussion. Only a few prospective clinical trials focused on the effects of surgery in relapsed ovarian cancer have been published. The available data show improvements in the prognosis due to complete cytoreduction in the setting of recurrence. However, the selection of eligible patients is the essential issue. Therefore, the establishment of reliable predictive factors for complete tumor resection as well as a definition of the group of patients who might profit from this approach remains a field for research. Further randomized trials designed to develop and incorporate operative standards for recurrent ovarian cancer should follow

American palm ethnomedicine: A meta-analysis

<p>Abstract</p> <p>Background</p> <p>Many recent papers have documented the phytochemical and pharmacological bases for the use of palms (<it>Arecaceae</it>) in ethnomedicine. Early publications were based almost entirely on interviews that solicited local knowledge. More recently, ethnobotanically guided searches for new medicinal plants have proven more successful than random sampling for identifying plants that contain biodynamic ingredients. However, limited laboratory time and the high cost of clinical trials make it difficult to test all potential medicinal plants in the search for new drug candidates. The purpose of this study was to summarize and analyze previous studies on the medicinal uses of American palms in order to narrow down the search for new palm-derived medicines.</p> <p>Methods</p> <p>Relevant literature was surveyed and data was extracted and organized into medicinal use categories. We focused on more recent literature than that considered in a review published 25 years ago. We included phytochemical and pharmacological research that explored the importance of American palms in ethnomedicine.</p> <p>Results</p> <p>Of 730 species of American palms, we found evidence that 106 species had known medicinal uses, ranging from treatments for diabetes and leishmaniasis to prostatic hyperplasia. Thus, the number of American palm species with known uses had increased from 48 to 106 over the last quarter of a century. Furthermore, the pharmacological bases for many of the effects are now understood.</p> <p>Conclusions</p> <p>Palms are important in American ethnomedicine. Some, like <it>Serenoa repens </it>and <it>Roystonea regia</it>, are the sources of drugs that have been approved for medicinal uses. In contrast, recent ethnopharmacological studies suggested that many of the reported uses of several other palms do not appear to have a strong physiological basis. This study has provided a useful assessment of the ethnobotanical and pharmacological data available on palms.</p

Threonine requirement of broiler from 22-42 days

Threonine is considered to be the third limiting amino acid for broiler chicks fed low protein corn-soybean meal diets. Very limited information is available on the requirement of the threonine for broilers. The aim of this study was to determine the threonine requirements of broiler chickens from 22-42 days of age. Seventy five Ross 308 one-day-old male broiler chicks were divided into five dietary treatment groups of similar mean weight, comprising 15 birds each. They were fed a basal starting diet containing 23% CP, 3200 ME kcal/kg, 0.81% threonine and 1.24% lysine for first 3 weeks. Chicks were randomly assigned to five treatments involving 0.70, 0.75, 0.80, 0.85 and 0.90% of total threonine for 21 days (between 22-42 days). Results indicated that a linear response to dietary threonine for final body weight, body weight gain and threonine intake occurred in experiment but other live performance parameters were not impacted by dietary threonine. Our results suggest that the current NRC recommendation of 0.74% threonine for 3-6 week old broilers is adequate to support comparable growth performance. © Asian Network for Scientific Information, 2009

Spondyloepiphyseal dysplasia tarda with progressive arthropathy

PubMed ID: 10870664Spondyloepiphyseal dysplasia tarda with progressive arthropathy, described by Wynne-Davies et al., is a rare autosomal recessive disorder. It is characterized by generalized platyspondyly and epiphyseal involvement, with enlargement of both ends of the short tubular bones of the hands. Clinical features include onset in childhood, a disproportionately short stature and premature osteoarthritis. We describe the clinical and radiographic findings of a young woman suffering from spondyloepiphyseal dysplasia tarda with progressive arthropathy

Axillary and Tympanic Temperature Measurement in Children and Normal Values for Ages

Aim The aim of the study was define the normal values of tympanic and axillary body temperature in healthy children. Methods This observational cross-sectional study was performed in healthy children aged 0 to 17 years who visited the ambulatory general pediatric of Istanbul Medical Faculty. Results Of 1364 children, 651 (47.7%) were girls and 713 were boys, the mean (SD, range) age was 72.5 (53.6, 1-204) months. The mean (SD) axillary body temperature was 36.04°C (0.46°C; minimum, 35.0°C; maximum, 37.6°C). The 95th and 99th percentiles were 36.8°C and 37.0°C, respectively. The mean (SD) tympanic body temperature was 36.91°C (0.46°C; minimum, 35.15°C; maximum, 37.9°C). The 95th and 99th percentiles were 37.6°C and 37.8°C, respectively. There were statistically significant differences between sexes for only tympanic body temperatures. Both axillary and tympanic body temperatures were statistically higher in 0 to 2 months compared with other age groups. For this age group, the 99th percentile was 37.5°C for axillary and 37.85°C for tympanic temperature. Conclusions Axillary and tympanic body temperatures should be considered as fever when they are more than 37.0°C and 37.8°C, respectively. For 0 to 2 months, fever is 37.5°C and 37.85°C in axillary and tympanic temperatures, respectively. © 2018 Wolters Kluwer Health, Inc. All rights reserved

Primary mucinous borderline tumor of the vermiform appendix mimicking ovarian carcinoma; case report

WOS: 000309738600020PubMed ID: 23185804Introduction: Primary adenocarcinoma of the vermiform appendix is a very rare entity. Borderline mucinous tumor of the appendix is a much more rare disease. Case: We present a 71-year-old woman with primary mucinous borderline tumor of the vermiform appendix. She was misdiagnosed as an ovarian carcinoma patient and operated on by a gynecologic oncology team. Her frozen section analysis of an appendicial mass resulted as borderline tumor of appendix vermiformis, and right hemicolectomy, as is advised in invasive colon tumors, was not carried out. Conclusion: Borderline mucinous tumor of the appendix vermiformis should be kept in mind in patients who have pseudomyxoma peritonei during surgery. Tumoral resection may be the definitive therapy in these patients

The role of the poputeal lymph nodes imaging for differentiating rheumatoid arthritis from osteoarthritis [Romatoi·d artri·ti·n osteoartri·tten ayirici tanisinda popli·teal lenf nodu görüntülemesi·ni·n yeri·]

• Objective: We wanted to assess the role of the popliteal lymph nodes for differentiating rheumatoid arthritis (RA) from osteoarthritis (OA) by using three dimensional-fast spoiled gradient echo (3D-FSPGR) MR imaging and colour doppler ultrasonography (CDU). • Material and Method: MR examination of the knee of 38 cases, 18 with rheumatoid arthritis (RA) and 20 with osteoarthritis (OA) were analyzed retrospectively. MR images were acquired with a 1.5-Tesla magnet. The MR imaging protocol consisted of 3D-FSPGR sequences in three planes. Images were reviewed to describe the number, size and centrally fatty changes of the popliteal lymph nodes. Additionally, these nodes were examined by CDU. Statistical Package for Social Sciences 11.0 program for Windows was performed for statistical analysis. • Results: The popliteal nodes were observed in 88.8% of RA cases and 30% of OA cases. The number of the nodes in the RA and OA group was 53, and 8, respectively. The mean size of the lymph nodes in the RA and OA group was 7.4mm, and 3.6mm, respectively. Central fatty was observed in 100% of OA cases and in 60.4% of RA cases. The hiler vascularization was observed in the only 13% of RA cases. Mean value of the RI was determined as 0.62+/-0.005. • Conclusion: Differentiating RA from OA, the criteria of the number, sizes and central fatty changes of the popliteal lymph nodes showed statistical significance. Performing 3D-FSPGR sequence in knee MR imaging might useful to describe these nodes. The hiler vascularization with low RIs in CDU is also helpful criteria to differentiating RA from OA