499 research outputs found
Seasonal influences on first-episode admission in affective and non-affective psychosis
Background: Since bipolar affective disorder has been recorded, clinicians treating patients with this disorder have noted the cyclic nature of episodes, particularly an increase in mania in the spring and summer months and depression during winter. Objective: The aim of this study was to investigate seasonality in symptom onset and service admissions over a period of 10 years in a group of patients (n= 359) with first-episode (FE) mania (n= 133), FE schizoaffective disorder (n= 49) and FE schizophrenia (n= 177). Method: Patients were recruited if they were between 15 and 28 years of age and if they resided in the geographical mental health service catchment area. The number of patients experiencing symptom onset and service admission over each month and season was recorded. Results: In terms of seasonality of time of service admission, the results indicate a high overall seasonality (particularly in men), which was observed in both the schizoaffective and the bipolar groups. In terms of seasonality of symptom onset, the results indicate that seasonality remains in the male bipolar group, but other groups have no seasonal trend. Conclusions: This provides further evidence that systems mediating the entrainment of biological rhythms to the environment may be more pronounced in BPAD than in schizoaffective disorder and schizophrenia. These results may help facilitate the preparedness of mental heath services for patients at different times of the yea
Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant inbred mouse strains. We mapped quantitative trait loci (QTLs) associated with variation in expression of thousands of transcripts. By comparing the physical transcript position with the location of the controlling QTL, we identified polymorphic cis-acting stem cell genes. We also identified multiple trans-acting control loci that modify expression of large numbers of genes. These groups of coregulated transcripts identify pathways that specify variation in stem cells. We illustrate this concept with the identification of candidate genes involved with HSC turnover. We compared expression QTLs in HSCs and brain from the same mice and identified both shared and tissue-specific QTLs. Our data are accessible through WebQTL, a web-based interface that allows custom genetic linkage analysis and identification of coregulated transcripts.
An examination of the effects of self-regulatory focus on the perception of the media richness: the case of email
Communication is a key element in organizations’ business success. The media richness theory and the channel expansion theory are two of the most influential theories regarding the selection and use of communication media in organizations; however, literature has focused little on the effects of self-regulation by managers and employees in these theories. To analyze these topics, this study develops an empirical investigation by gathering data from 600 managers and employees using a questionnaire. The results suggest that the perception of media richness is positively affected when the individual shows a promotion focus or strategy.Peer ReviewedPostprint (author’s final draft
3D Position Sensitive XeTPC for Dark Matter Search
The technique to realize 3D position sensitivity in a two-phase xenon time
projection chamber (XeTPC) for dark matter search is described. Results from a
prototype detector (XENON3) are presented.Comment: Presented at the 7th UCLA Symposium on "Sources and Detection of Dark
Matter and Dark Energy in the Universe
Constraints on inelastic dark matter from XENON10
It has been suggested that dark matter particles which scatter inelastically
from detector target nuclei could explain the apparent incompatibility of the
DAMA modulation signal (interpreted as evidence for particle dark matter) with
the null results from CDMS-II and XENON10. Among the predictions of
inelastically interacting dark matter are a suppression of low-energy events,
and a population of nuclear recoil events at higher nuclear recoil equivalent
energies. This is in stark contrast to the well-known expectation of a falling
exponential spectrum for the case of elastic interactions. We present a new
analysis of XENON10 dark matter search data extending to E keV
nuclear recoil equivalent energy. Our results exclude a significant region of
previously allowed parameter space in the model of inelastically interacting
dark matter. In particular, it is found that dark matter particle masses
GeV are disfavored.Comment: 8 pages, 4 figure
First Results from the XENON10 Dark Matter Experiment at the Gran Sasso National Laboratory
The XENON10 experiment at the Gran Sasso National Laboratory uses a 15 kg
xenon dual phase time projection chamber (XeTPC) to search for dark matter
weakly interacting massive particles (WIMPs). The detector measures
simultaneously the scintillation and the ionization produced by radiation in
pure liquid xenon, to discriminate signal from background down to 4.5 keV
nuclear recoil energy. A blind analysis of 58.6 live days of data, acquired
between October 6, 2006 and February 14, 2007, and using a fiducial mass of 5.4
kg, excludes previously unexplored parameter space, setting a new 90% C.L.
upper limit for the WIMP-nucleon spin-independent cross-section of 8.8 x
10^{-44} cm^2 for a WIMP mass of 100 GeV/c^2, and 4.5 x 10^{-44} cm^2 for a
WIMP mass of 30 GeV/c^2. This result further constrains predictions of
supersymmetric models.Comment: accepted for publication in Phys. Rev. Let
A search for light dark matter in XENON10 data
We report results of a search for light (<10 GeV) particle dark matter with
the XENON10 detector. The event trigger was sensitive to a single electron,
with the analysis threshold of 5 electrons corresponding to 1.4 keV nuclear
recoil energy. Considering spin-independent dark matter-nucleon scattering, we
exclude cross sections \sigma_n>3.5x10^{-42} cm^2, for a dark matter particle
mass m_{\chi}=8 GeV. We find that our data strongly constrain recent elastic
dark matter interpretations of excess low-energy events observed by CoGeNT and
CRESST-II, as well as the DAMA annual modulation signal.Comment: Manuscript identical to v2 (published version) but also contains
erratum. Note v3==v2 but without \linenumber
Parity-Violating Interaction Effects I: the Longitudinal Asymmetry in pp Elastic Scattering
The proton-proton parity-violating longitudinal asymmetry is calculated in
the lab-energy range 0--350 MeV, using a number of different, latest-generation
strong-interaction potentials--Argonne V18, Bonn-2000, and Nijmegen-I--in
combination with a weak-interaction potential consisting of rho- and
omega-meson exchanges--the model known as DDH. The complete scattering problem
in the presence of parity-conserving, including Coulomb, and parity-violating
potentials is solved in both configuration- and momentum-space. The predicted
parity-violating asymmetries are found to be only weakly dependent upon the
input strong-interaction potential adopted in the calculation. Values for the
rho- and omega-meson weak coupling constants and
are determined by reproducing the measured asymmetries at 13.6 MeV, 45 MeV, and
221 MeV.Comment: 24 pages, 8 figures, submitted to Physical Review
Boolean network model predicts cell cycle sequence of fission yeast
A Boolean network model of the cell-cycle regulatory network of fission yeast
(Schizosaccharomyces Pombe) is constructed solely on the basis of the known
biochemical interaction topology. Simulating the model in the computer,
faithfully reproduces the known sequence of regulatory activity patterns along
the cell cycle of the living cell. Contrary to existing differential equation
models, no parameters enter the model except the structure of the regulatory
circuitry. The dynamical properties of the model indicate that the biological
dynamical sequence is robustly implemented in the regulatory network, with the
biological stationary state G1 corresponding to the dominant attractor in state
space, and with the biological regulatory sequence being a strongly attractive
trajectory. Comparing the fission yeast cell-cycle model to a similar model of
the corresponding network in S. cerevisiae, a remarkable difference in
circuitry, as well as dynamics is observed. While the latter operates in a
strongly damped mode, driven by external excitation, the S. pombe network
represents an auto-excited system with external damping.Comment: 10 pages, 3 figure
- …