The end-to-end testbed of the Optical Metrology System on-board LISA Pathfinder

LISA Pathfinder is a technology demonstration mission for the Laser Interferometer Space Antenna (LISA). The main experiment on-board LISA Pathfinder is the so-called LISA Technology Package (LTP) which has the aim to measure the differential acceleration between two free-falling test masses with an accuracy of 3x10^(-14) ms^(-2)/sqrt[Hz] between 1 mHz and 30 mHz. This measurement is performed interferometrically by the Optical Metrology System (OMS) on-board LISA Pathfinder. In this paper we present the development of an experimental end-to-end testbed of the entire OMS. It includes the interferometer and its sub-units, the interferometer back-end which is a phasemeter and the processing of the phasemeter output data. Furthermore, 3-axes piezo actuated mirrors are used instead of the free-falling test masses for the characterisation of the dynamic behaviour of the system and some parts of the Drag-free and Attitude Control System (DFACS) which controls the test masses and the satellite. The end-to-end testbed includes all parts of the LTP that can reasonably be tested on earth without free-falling test masses. At its present status it consists mainly of breadboard components. Some of those have already been replaced by Engineering Models of the LTP experiment. In the next steps, further Engineering Models and Flight Models will also be inserted in this testbed and tested against well characterised breadboard components. The presented testbed is an important reference for the unit tests and can also be used for validation of the on-board experiment during the mission

Unbiased likelihood-free inference of the Hubble constant from light standard sirens

Multimessenger observations of binary neutron star mergers offer a promising path toward resolution of the Hubble constant ( H 0 ) tension, provided their constraints are shown to be free from systematics such as the Malmquist bias. In the traditional Bayesian framework, accounting for selection effects in the likelihood requires calculation of the expected number (or fraction) of detections as a function of the parameters describing the population and cosmology; a potentially costly and/or inaccurate process. This calculation can, however, be bypassed completely by performing the inference in a framework in which the likelihood is never explicitly calculated, but instead fit using forward simulations of the data, which naturally include the selection. This is likelihood-free inference (LFI). Here, we use density-estimation LFI, coupled to neural-network-based data compression, to infer H 0 from mock catalogues of binary neutron star mergers, given noisy redshift, distance and peculiar velocity estimates for each object. We demonstrate that LFI yields statistically unbiased estimates of H 0 in the presence of selection effects, with precision matching that of sampling the full Bayesian hierarchical model. Marginalizing over the bias increases the H 0 uncertainty by only 6% for training sets consisting of O ( 10 4 ) populations. The resulting LFI framework is applicable to population-level inference problems with selection effects across astrophysics

Effect of ELF e.m. fields on metalloprotein redox-active sites

The peculiarity of the distribution and geometry of metallic ions in enzymes pushed us to set the hypothesis that metallic ions in active-site act like tiny antennas able to pick up very feeble e.m. signals. Enzymatic activity of Cu2+, Zn2+ Superoxide Dismutase (SOD1) and Fe2+ Xanthine Oxidase (XO) has been studied, following in vitro generation and removal of free radicals. We observed that Superoxide radicals generation by XO is increased by a weak field having the Larmor frequency fL of Fe2+ while the SOD1 kinetics is sensibly reduced by exposure to a weak field having the frequency fL of Cu2+ ion.Comment: 18 pages, 4 figure

A new dataset and empirical relationships between magnitude/intensity and epicentral distance for liquefaction in central-eastern Sicily

Strong earthquakes can trigger several phenomena inducing soil deformation, such as liquefaction, ground fracturing and landslides, which can often cause more damage than the seismic shaking itself. A research performed on numerous historical accounts reporting descriptions of seismogeological effects in central-eastern Sicily, allowed the authors to update the previous liquefaction datasets. 75 liquefaction-induced phenomena observed in 26 sites, triggered by 14 earthquakes, have been used to define relationships between intensity/magnitude values and epicentral distance from the liquefied sites. The proposed upper bound-curves, at regional scale for central- eastern Sicily, are realized by using the updating liquefaction dataset and also the new CPTI04 Italian earthquake parametric catalogue. These relationships can be useful in hazard assessment to evaluate the minimum energy of an earthquake inducing liquefactions

Evaluation of the efficacy of animal-assisted therapy based on the reality orientation therapy protocol in Alzheimer's disease patients: a pilot study.

BACKGROUND: The aim of this study was to evaluate the efficacy of animal-assisted therapy (AAT) in elderly patients affected by Alzheimer's disease based on the formal reality orientation therapy (ROT) protocol. METHODS: Our study was carried out at an Alzheimer's centre for 6 months. A homogeneous sample (age, Mini-Mental State Examination (MMSE), 15-item Geriatric Depression Scale (GDS)) of 50 patients was selected at random and successively. Patients were divided into three groups: (i) 20 patients received a course of AAT (AAT group) based on the ROT protocol; (ii) 20 patients were engaged exclusively in activities based on the ROT group; and (iii) 10 patients (control group) participated in no stimulations. MMSE and GDS were administered at time 0 (T0 ) and time 1 (T1 ) to all three groups. Differences within groups between T0 and T1 for GDS and MMSE scores were analyzed by Student's t-test. Differences between group means were analyzed using an anova test with the Bonferroni-Dunn test for post-hoc comparisons. RESULTS: Both the AAT group and ROT group had improved GDS scores and showed a slight improvement in terms of mood. On the GDS, the AAT group improved from 11.5 (T0 ) to 9.5 (T1 ), and the ROT group improved from 11.6 (T0 ) to 10.5 (T1 ). At the same time, a slight improvement in cognitive function, as measured by the MMSE, was observed. In the AAT group, mean MMSE was 20.2 at T0 and 21.5 at T1 , and in the ROT group, it was 19.9 at T0 and 20.0 at T1 . In the control group, the average values of both the GDS and MMSE remained unchanged. The Bonferroni-Dunn results showed statistically significant differences between groups, particularly between the AAT group and the other two (P < 0.001). CONCLUSIONS: Pet therapy interventions based on the formal ROT protocol were effective and, compared to the ROT, provided encouraging and statistically significant results

Discrimination of tsunami sources (Earthquake vs. Landslide) on the basis of historical data in Eastern Sicily and southern Calabria

The source mechanisms responsible for large historical tsunamis that have struck eastern Sicily and southern Calabria are a topic of robust debate. We have compiled a database of historical coeval descriptions of three large tsunamis: 11 January 1693, 6 February 1783, and 28 December 1908. By using accounts of run-up and inundation and employing an approach proposed by Okal and Synolakis in 2004, we can provide discriminants to define the nature of the near-field tsunami sources (fault dislocation or landslide). Historical reports for the 1908 event describe affected localities, maximum runups, and inundation areas. However, for the 1693 and 1783 tsunamis, reports are limited to inundation and occasional run-up estimates. We calculate run-up values for these events using available relations between inundation and run-up. We employed the model of Okal and Synolakis to the obtained profiles of tsunami run-up along the inundated shorelines. The 1908 run-up data distribution confirms that the tsunami is compatible with a seismic dislocation source, whereas the 1783 data supports contemporary observations and recent offshore investigations suggesting that the tsunami was produced by an earthquake-triggered submarine landslide. Analysis of the 1693 event data suggests that the tsunami was generated during a tectonic event and thus a seismogenic source should be found offshore

Modeling provincial Covid-19 epidemic data in Italy using an adjusted time-dependent SIRD model

In this paper we develop a predictive model for the spread of COVID-19 infection at a provincial (i.e. EU NUTS-3) level in Italy by using official data from the Italian Ministry of Health integrated with data extracted from daily official press conferences of regional authorities and from local newspaper websites. This integration is mainly concerned with COVID-19 cause specific death data which are not available at NUTS-3 level from open official data data channels. An adjusted time-dependent SIRD model is used to predict the behavior of the epidemic, specifically the number of susceptible, infected, deceased and recovered people. Predictive model performance is evaluated using comparison with real data