A thyrotropin‑secreting macroadenoma with positive growth hormone and prolactin immunostaining: A case report and literature review

Thyrotropin (thyroid stimulating hormone [TSH]) secreting pituitary adenomas (TSHoma) are rare adenomas presenting with hyperthyroidism due to impaired negative feedback of thyroid hormone on the pituitary and inappropriate TSH secretion. This article presents a case of TSH‑secreting macroadenoma without any clinical hyperthyroidism symptoms accompanying immunoreaction with growth hormone (GH) and prolactin. A 36‑year‑old female patient was admitted with complaints of irregular menses and blurred vision. On physical exam, she had bitemporal hemianopsia defect. Magnetic resonance imaging (MRI) evaluation showed suprasellar macroadenoma measuring 33 mm × 26 mm × 28 mm was detected on pituitary MRI. She had no hyperthyroidism symptoms clinically. Although free T4 and free T3 levels were elevated, TSH level was inappropriately within the upper limit of normal. Response to T3 suppression and thyrotropin releasing hormone‑stimulation test was inadequate. Other pituitary hormones were normal. Transsphenoidal adenomectomy was performed due to parasellar compression findings. Immunohistochemically widespread reaction was observed with TSH, GH and prolactin in the adenoma. The patient underwent a second surgical procedure 2 months later due to macroscopic residual tumor, bitemporal hemianopsia and a suprasellar homogenous uptake with regular borders on indium‑111 octreotide scintigraphy. After second surgery; due to ongoing symptoms and residual tumor, she was managed with octreotide and cabergoline treatment. On her follow‑up with medical treatment, TSH and free T4 values were within normal limits. Although silent TSHomas are rare, they may arise with compression symptoms as in our case. The differential diagnosis of secondary hyperthyroidism should include TSHomas and thyroid hormone receptor resistance syndrome.Key words: Inappropriate thyroid stimulating hormone, thyrotropin‑secreting pituitary adenoma, thyroid stimulating hormone adenom

Linguistic signatures of regulatory focus: How abstraction fits promotion more than prevention

In 3 experiments, the authors investigated how strategic inclinations associated with promotion versus prevention orientations - that is, eager approach versus vigilant avoidance, respectively - affect the use of language. It is hypothesized that eager promotion strategies used to attain desired end states entail using more abstract language than used with vigilant prevention strategies. This is shown to hold for experimentally induced relationship goals (Experiment 1) and communication goals (Experiment 2). In the 3rd experiment, the authors examined the impact of abstractly and concretely worded messages upon the behavioral intentions of chronically prevention- and promotion-oriented individuals and found support for the hypothesis that behavioral intentions to engage in specific activities are stronger when there is a fit between message wording and chronic orientation than when there is no fit. The broader implications of these findings are discussed. Copyright 2005 by the American Psychological Association

XMM-Newton and Swift observations of WZ Sge: spectral and timing analysis

WZ Sagittae is the prototype object of a subclass of dwarf novae, with rare and long (super)outbursts, in which a white dwarf primary accretes matter from a low mass companion. High-energy observations offer the possibility of a better understanding of the disk-accretion mechanism in WZ Sge-like binaries. We used archival XMM-Newton and Swift data to characterize the X-ray spectral and temporal properties of WZ Sge in quiescence. We performed a detailed timing analysis of the simultaneous X-ray and UV light curves obtained with the EPIC and OM instruments on board XMM-Newton in 2003. We employed several techniques in this study, including a correlation study between the two curves. We also performed an X-ray spectral analysis using the EPIC data, as well as Swift/XRT data obtained in 2011. We find that the X-ray intensity is clearly modulated at a period of about 28.96 s, confirming previously published preliminary results. We find that the X-ray spectral shape of WZ Sge remains practically unchanged between the XMM-Newton and Swift observations. However, after correcting for inter-stellar absorption, the intrinsic luminosity is estimated to be about 2.65X10^ 30 erg/s/cm^2 and 1.57X10^30 erg/s/cm^2 in 2003 and 2011, respectively. During the Swift/XRT observation, the observed flux is a factor of about 2 lower than that observed by XMM-Newton, but is similar to the quiescent levels observed various times before the 2001 outburst.Comment: Accepted for publication on A&A.10 pages, 9 figure

Lie experts' beliefs about non-verbal indicators of deception

ABSTRACT.. Beliefs about behavioral clues to deception were investigated in 212 people, consisting of prisoners, police detectives, patrol police officers, prison guards, customs officers, and college students. Previous studies, mainly conducted with college students as subjects, showed that people have some incorrect beliefs about behavioral clues to deception. It was hypothesized that prisoners would have the best notion about clues of deception, due to the fact that they receive the most adequate feedback about successful deception strategies. The results supported this hypothesis