45 research outputs found
Toxicity thresholds of nine herbicides to coral symbionts (Symbiodiniaceae)
Over 30 herbicides have been detected in catchments and waters of the Great Barrier Reef (GBR) and their toxicity to key tropical species, including the coral endosymbiotic algae Symbiodiniaceae, is not generally considered in current water quality guideline values (WQGVs). Mutualistic symbionts of the family Symbiodiniaceae are essential for the survival of scleractinian corals. We tested the effects of nine GBR-relevant herbicides on photosynthetic efficiency (Delta F/F-m ') and specific growth rate (SGR) over 14 days of cultured coral endosymbiont Cladocopium goreaui (formerly Symbiodinium clade C1). All seven Photosystem II (PSII) herbicides tested inhibited Delta F/F-m ' and SGR, with toxicity thresholds for SGR ranging between 2.75 and 320 mu g L-1 (no effect concentration) and 2.54-257 mu g L-1 (EC10). There was a strong correlation between EC(50)s for Delta F/F-m ' and SGR for all PSII herbicides indicating that inhibition of Delta F/F-m ' can be considered a biologically relevant toxicity endpoint for PSII herbicides to this species. The non-PSII herbicides haloxyfop and imazapic did not affect Delta F/F-m ' or SGR at the highest concentrations tested. The inclusion of this toxicity data for Symbiodiniaceae will contribute to improving WQGVs to adequately inform risk assessments and the management of herbicides in tropical marine ecosystems
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Estimating the value of jointly optimized electric power generation and end use: a study of ISO-scale load shaping applied to the residential building stock
A generation-to-load simulation estimated the impact, in terms of production costs and CO2 emissions, attributable to the joint optimization of electric power generation and flexible end uses to support increasing penetrations of renewable energy. Newly conceived, evaluated, and foundational in developing a U.S. National Standard was a transaction-less yet continuous demand response system based on a day-ahead optimum load shape (OLS) designed to encourage Internet-connected devices to autonomously and voluntarily explore options to favour lowest cost generators – without requiring two-way communications, personally identifiable information, or customer opt-in. Boundary conditions used for model calibration included historical weather, residential building stock construction attributes, home appliance and device empirical operating schedules, prototypical power distribution feeder models, thermal generator heat rates, startup and ramping constraints, and fuel costs. Results of an hourly-based annual case study of Texas indicate a 1/3 reduction in production costs and a 1/5 reduction in CO2 emissions are possible.</p
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Characterizing Electric Grid System Benefits of MPC-Based Residential Load Shaping
Routinely encouraging and discouraging residential electric load throughout the day will be increasingly crit-ical in efficiently managing the smart grid to reliably de-liver clean, low-cost electricity. Yet, manipulating the duty cycles of thermostatically controlled loads such as heating, air conditioning, and hot water heaters can have the effect of destabilizing or stabilizing the grid. This work explores the potential for price-responsive control of residential air conditioning to shape electric demand at the distribution feeder level to minimize electricity production costs. Physical models of the interplay be-tween building thermal and electric loads are used to simulate time-series temperature and load behaviour. In-stantaneous load-adding and load-shedding opportuni-ties are quantified in more than 100,000 individual homes on 204 distribution feeders with results presented for 35 cities across the United States. In the context of distributed model predictive control, simulation of feeder-level response to a residential day-ahead 5-mi-nute pricing vector to 2,146 homes highlights an aggre-gate impact of flexible loads.</p
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Empirical Investigations of the Opportunity Limits of Automatic Residential Electric Load Shaping
Residential electric load shaping is often implemented as infrequent, utility-initiated, short-duration deferral of peak demand through direct load control. In contrast, investigated herein is the potential for frequent, transactive, intraday, consumer-configurable load shaping for storage-capable thermostatically controlled electric loads (TCLs) including refrigerators, freezers, and hot water heaters. Unique to this study are 28 months of 15-minute-interval observations of usage in 101 homes in the Pacific Northwest United States that specify start, duration, and usage patterns of approximately 25 submetered loads per home. The magnitudes of the load shift from voluntarily-participating TCL appliances are aggregated to form hourly upper and lower load-shaping limits for the coordination of electrical generation, transmission, distribution, storage, and demand. Empirical data are statistically analyzed to define metrics that help quantify load-shaping opportunities.</p
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Quantifying the Opportunity Limits of Automatic Residential Electric Load Shaping
Electric utility residential demand response programs typically do not shape load using intraday, transactive, and local setpoint adjustments of storage-capable thermostatically controlled loads (TCL). In the future, it is envisioned that utilities will continually broadcast forecast dynamic prices of electricity to automatically shape residential load and create load elasticity by alternatively encouraging or discouraging electric energy use. In this research, a binary conditional algorithm was developed and applied to TCL appliance empirical time series data to estimate price-based instantaneous load add and shed opportunities. To overcome limitations of traditional stochastic methods in quantifying diverse, non-normal, non-stationary distributions, recent developments in spectral methods were applied to capture and simulate load in both the frequency and time domains. The performance of autoregressive and spectral reconstruction methods was compared, with phase reconstruction providing the best simulation ensembles. The terminal application of this work is simulating the monetary savings anticipated from wide-scale deployment of price-responsive model predictive control of air conditioning, domestic hot water (DHW) heating, and battery systems.</p
Chronic Exposure of Corals to Fine Sediments: Lethal and Sub-Lethal Impacts
Understanding the sedimentation and turbidity thresholds for corals is critical in assessing the potential impacts of dredging projects in tropical marine systems. In this study, we exposed two species of coral sampled from offshore locations to six levels of total suspended solids (TSS) for 16 weeks in the laboratory, including a 4 week recovery period. Dose-response relationships were developed to quantify the lethal and sub-lethal thresholds of sedimentation and turbidity for the corals. The sediment treatments affected the horizontal foliaceous species (Montipora aequituberculata) more than the upright branching species (Acropora millepora). The lowest sediment treatments that caused full colony mortality were 30 mg l−1 TSS (25 mg cm−2 day−1) for M. aequituberculata and 100 mg l−1 TSS (83 mg cm−2 day−1) for A. millepora after 12 weeks. Coral mortality generally took longer than 4 weeks and was closely related to sediment accumulation on the surface of the corals. While measurements of damage to photosystem II in the symbionts and reductions in lipid content and growth indicated sub-lethal responses in surviving corals, the most reliable predictor of coral mortality in this experiment was long-term sediment accumulation on coral tissue
Factors Affecting Sentinel Node Metastasis in Thin (T1) Cutaneous Melanomas: Development and External Validation of a Predictive Nomogram
PURPOSE
Thin melanomas (T1; ≤ 1 mm) constitute 70% of newly diagnosed cutaneous melanomas. Regional node metastasis determined by sentinel node biopsy (SNB) is an important prognostic factor for T1 melanoma. However, current melanoma guidelines do not provide clear indications on when to perform SNB in T1 disease and stress an individualized approach to SNB that considers all clinicopathologic risk factors. We aimed to identify determinants of sentinel node (SN) status for incorporation into an externally validated nomogram to better select patients with T1 disease for SNB.
PATIENTS AND METHODS
The development cohort comprised 3,666 patients with T1 disease consecutively treated at the Istituto Nazionale Tumori (Milan, Italy) between 2001 and 2018; 4,227 patients with T1 disease treated at 13 other European centers over the same period formed the validation cohort. A random forest procedure was applied to the development data set to select characteristics associated with SN status for inclusion in a multiple binary logistic model from which a nomogram was elaborated. Decision curve analyses assessed the clinical utility of the nomogram.
RESULTS
Of patients in the development cohort, 1,635 underwent SNB; 108 patients (6.6%) were SN positive. By univariable analysis, age, growth phase, Breslow thickness, ulceration, mitotic rate, regression, and lymphovascular invasion were significantly associated with SN status. The random forest procedure selected 6 variables (not growth phase) for inclusion in the logistic model and nomogram. The nomogram proved well calibrated and had good discriminative ability in both cohorts. Decision curve analyses revealed the superior net benefit of the nomogram compared with each individual variable included in it as well as with variables suggested by current guidelines.
CONCLUSION
We propose the nomogram as a decision aid in all patients with T1 melanoma being considered for SNB
Comparison of the significant differences in the selected aspects of interpersonal relationships between medical students and student nurses affecting quality of patient care
Phototoxic effects of two common marine fuels on the settlement success of the coral Acropora tenuis
Coral reefs are at risk of exposure to petroleum hydrocarbons from shipping spills and uncontrolled discharges during extraction. The toxicity of petroleum hydrocarbons can substantially increase in the presence of ultraviolet radiation (UVR), therefore spills in shallow coral reef environments may be particularly hazardous to reef species. Here we investigated the sensitivity of coral larvae (Acropora tenuis) to dissolved hydrocarbons from heavy fuel oil (HFO) and diesel in the absence and presence of UVR. Larval settlement success decreased with increasing concentrations of dissolved HFO, and co-exposure to UVR doubled the toxicity: 50% effect concentrations (EC50) decreased from 96 (−UVR) to 51 (+UVR) total petroleum aromatic hydrocarbons (TPAH). Toxic thresholds for HFO were similar to concentrations reported during marine spills: EC10s of 24 (−UVR) and 15 (+UVR) µg l−1. While less toxic, diesel also reduced settlement and exhibited phototoxicity: EC10s of 122 (+UVR) and 302 (−UVR) µg l−1. This study demonstrates that the presence of UVR increases the hazard posed by oil pollution to tropical, shallow-water coral reefs. Further research on the effects of oils in the presence of UVR is needed to improve the environmental relevance of risk assessments and ensure appropriate protection for shallow reef environments against oil pollution
Nundinae e tri(num)nundinum. Tra realtà fondatrice e convenzionalità rituale nel sistema calendariale romano
Herbicides are detected year-round in marine waters, including those of the World Heritage listed Great Barrier Reef (GBR). The few previous studies that have investigated herbicide persistence in seawater generally reported half-lives in the order of months, and several studies were too short to detect significant degradation. Here we investigated the persistence of eight herbicides commonly detected in the GBR or its catchments in standard OECD simulation flask experiments, but with the aim to mimic natural conditions similar to those found on the GBR (i.e., relatively low herbicide concentrations, typical temperatures, light and microbial communities). Very little degradation was recorded over the standard 60 d period (Experiment 1) so a second experiment was extended to 365 d. Half-lives of PSII herbicides ametryn, atrazine, diuron, hexazinone and tebuthiuron were consistently greater than a year, indicating high persistence. The detection of atrazine and diuron metabolites and longer persistence in mercuric chloride-treated seawater confirmed that biodegradation contributed to the breakdown of herbicides. The shortest half-life recorded was 88 d for growth-regulating herbicide 2,4-D at 31°C in the dark, while the fatty acid-inhibitor metolachlor exhibited a minimum half-life of 281 d. The presence of moderate light and elevated temperatures affected the persistence of most of the herbicides; however, the scale and direction of the differences were not predictable and were likely due to changes in microbial community composition. The persistence estimates here represent some of the first appropriate data for application in risk assessments for herbicide exposure in tropical marine systems. The long persistence of herbicides identified in the present study helps explain detection of herbicides in nearshore waters of the GBR year round. Little degradation of these herbicides would be expected during the wet season with runoff and associated flood plumes transporting a high proportion of the original herbicide from rivers into the GBR lagoon