7,696 research outputs found
On central tendency and dispersion measures for intervals and hypercubes
The uncertainty or the variability of the data may be treated by considering,
rather than a single value for each data, the interval of values in which it
may fall. This paper studies the derivation of basic description statistics for
interval-valued datasets. We propose a geometrical approach in the
determination of summary statistics (central tendency and dispersion measures)
for interval-valued variables
Computing Inferences for Large-Scale Continuous-Time Markov Chains by Combining Lumping with Imprecision
If the state space of a homogeneous continuous-time Markov chain is too
large, making inferences - here limited to determining marginal or limit
expectations - becomes computationally infeasible. Fortunately, the state space
of such a chain is usually too detailed for the inferences we are interested
in, in the sense that a less detailed - smaller - state space suffices to
unambiguously formalise the inference. However, in general this so-called
lumped state space inhibits computing exact inferences because the
corresponding dynamics are unknown and/or intractable to obtain. We address
this issue by considering an imprecise continuous-time Markov chain. In this
way, we are able to provide guaranteed lower and upper bounds for the
inferences of interest, without suffering from the curse of dimensionality.Comment: 9th International Conference on Soft Methods in Probability and
Statistics (SMPS 2018
The European COST Action EUBrewNet: towards consistency in quality control, quality assurance and coordinated operations of the Brewer Instrument
Presentación realizada en: 10th meeting of the Ozone Research Managers (ORM) como parte de "Vienna Convention for the Protection of the Ozone Layer", celebrado en Ginebra (Suiza) del 28 al 30 de marzo de 2017
The Nuclear Yukawa Model on a Lattice
We present the results of the quantum field theory approach to nuclear Yukawa
model obtained by standard lattice techniques. We have considered the simplest
case of two identical fermions interacting via a scalar meson exchange.
Calculations have been performed using Wilson fermions in the quenched
approximation. We found the existence of a critical coupling constant above
which the model cannot be numerically solved. The range of the accessible
coupling constants is below the threshold value for producing two-body bound
states. Two-body scattering lengths have been obtained and compared to the non
relativistic results.Comment: 15 page
Aberrant DNA Methylation Reprogramming During Induced Pluripotent Stem Cell Generation is Dependent on the Choice of Reprogramming Factors
The conversion of somatic cells into pluripotent stem cells via overexpression of reprogramming factors involves epigenetic remodeling. DNA methylation at a significant proportion of CpG sites in induced pluripotent stem cells (iPSCs) differs from that of embryonic stem cells (ESCs). Whether different sets of reprogramming factors influence the type and extent of aberrant DNA methylation in iPSCs differently remains unknown. In order to help resolve this critical question, we generated human iPSCs from a common fibroblast cell source using either the Yamanaka factors (OCT4, SOX2, KLF4 and cMYC) or the Thomson factors (OCT4, SOX2, NANOG and LIN28), and determined their genome-wide DNA methylation profiles. In addition to shared DNA methylation aberrations present in all our iPSCs, we identified Yamanaka-iPSC (Y-iPSC)-specific and Thomson-iPSC (T-iPSC)-specific recurrent aberrations. Strikingly, not only were the genomic locations of the aberrations different but also their types: reprogramming with Yamanaka factors mainly resulted in failure to demethylate CpGs, whereas reprogramming with Thomson factors mainly resulted in failure to methylate CpGs. Differences in the level of transcripts encoding DNMT3b and TET3 between Y-iPSCs and T-iPSCs may contribute partially to the distinct types of aberrations. Finally, de novo aberrantly methylated genes in Y-iPSCs were enriched for NANOG targets that are also aberrantly methylated in some cancers. Our study thus reveals that the choice of reprogramming factors influences the amount, location, and class of DNA methylation aberrations in iPSCs. These findings may provide clues into how to produce human iPSCs with fewer DNA methylation abnormalities
The High Frequency Instrument of Planck: Requirements and Design
The Planck satellite is a project of the European Space Agency based on a wide international collaboration, including United States and Canadian laboratories. It is dedicated to the measurement of the anisotropy of the Cosmic Microwave Background (CMB) with unprecedented sensitivity and angular resolution. The detectors of its High frequency Instrument (HFI) are bolometers cooled down to 100 mK. Their sensitivity will be limited by the photon noise of the CMB itself at low frequencies, and of the instrument background at high frequencies. The requirements on the measurement chain are directly related to the strategy of observation used for the satellite. Due to the scanning on the sky, time features of the measurement chain are directly transformed into angular features in the sky maps. This impacts the bolometer design as well as other elements: For example, the cooling system must present outstanding temperature stability, and the amplification chain must show, down to very low frequencies, a flat noise spectrum
Polarization of the WMAP Point Sources
The detection of polarized sources in the WMAP 5-year data is a very
difficult task. The maps are dominated by instrumental noise and only a handful
of sources show up as clear peaks in the Q and U maps. Optimal linear filters
applied at the position of known bright sources detect with a high level of
significance a polarized flux P from many more sources, but estimates of P are
liable to biases. Using a new technique, named the "filtered fusion technique",
we have detected in polarization, with a significance level greater than 99.99%
in at least one WMAP channel, 22 objects, 5 of which, however, do not have a
plausible low radio frequency counterpart and are therefore doubtful. Estimated
polarized fluxes P < 400 mJy at 23 GHz were found to be severely affected by
the Eddington bias. The corresponding polarized flux limit for Planck/LFI at 30
GHz, obtained via realistic simulations, is 300 mJy. We have also obtained
statistical estimates of, or upper limits to the mean polarization degrees of
bright WMAP sources at 23, 33, 41, and 61 GHz, finding that they are of a few
percent.Comment: 10 pages, 6 figures. Accepted for publication in Ap
Mapping the CMB Sky: The BOOMERANG experiment
We describe the BOOMERanG experiment, a stratospheric balloon telescope
intended to measure the Cosmic Microwave Background anisotropy at angular
scales between a few degrees and ten arcminutes. The experiment has been
optimized for a long duration (7 to 14 days) flight circumnavigating Antarctica
at the end of 1998. A test flight was performed on Aug.30, 1997 in Texas. The
level of performance achieved in the test flight was satisfactory and
compatible with the requirements for the long duration flight.Comment: 11 pages, 6 figure
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