Pemeriksaan Kuat Tarik Belah Beton Dengan Variasi Agregat Yang Berasal Dari Beberapa Tempat Di Sulawesi Utara

Kekuatan beton menjadi tinjauan yang penting untuk kebutuhan perencanaan desain struktur. Kekuatan beton yang menjadi salah satu parameter utama dalam perencanaan adalah kuat tarik belah beton. Dengan memanfaatkan material yang bisa dijangkau dari beberapa tempat yang berbeda khususnya Sulawesi Utara menjadi alternatif untuk dijadikan sebagai bahan pembentuk beton. Nilai kuat tarik belah diteliti dalam penelitian ini. Dengan agregat kasar yaitu kerikil pecah dan kerikil alam, dan agregat halus pasir Ranoyapo, pasir Girian, pasir Sawangan dan pasir Klabat, menjadi 8 komposisi campuran dengan 4 benda uji tiap campuran. Pengujian dilakukan dengan menggunakan mesin uji “Semiautomatic Concrete Compression Testing 400 kN Cap. Controls – Italy 50-C6632”. Hasil-hasil pengujian menunjukkan ternyata beton yang menggunakan kerikil pecah dan pasir girian yang mendapatkan nilai kuat tarik belah tertinggi dari semua kombinasi agregat pada umur 28 hari. Hasil penelitian juga menunjukkan bahwa penggunaan kerikil alam sebagai agregat kasar pada beton lebih kecil dari kerikil pecah

Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot

Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehensive understanding of the processes involved in the self assembly of the colloidal structures discussed therein is essential for the development of relevant biomedical applications. In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes.Istituto Italiano di Tecnologia (IIT)COST Action [CA 15107]People Program (Marie Curie Actions) of the European Union's Seventh Framework Program under REA [606713 BIBAFOODS]Portuguese Foundation for Science and Technology (FCT) [PTDC/AGR-TEC/4814/2014, IF/01005/2014]Fundacao para a Ciencia e Tecnologia [SFRH/BPD/99982/2014]Danish National Research Foundation [DNRF 122]Villum Foundation [9301]Italian Ministry of Instruction, University and Research (MIUR), PRIN [20109PLMH2]"Fondazione Beneficentia Stiftung" VaduzFondo di Ateneo FRAFRAinfo:eu-repo/semantics/publishedVersio

Deskripsi Alga Makro di Taman Wisata Alam Batuputih, Kota Bitung

DESKRIPSI ALGA MAKRO DI TAMAN WISATA ALAM BATUPUTIH, KOTA BITUNG Marnix L.D. Langoy1), Saroyo1), Farha N.J. Dapas1), Deidy Y. Katili 1), dan Syamsul Bachry Hamsir2) 1)Program Studi Biologi, FMIPA, Universitas Sam Ratulangi, Manado 95115 2)Mahasiswa Program Sarjana Program Studi Biologi FMIPA Universitas Sam Ratulangi Manado 95115 ABSTRAK Penelitian tentang biodiversitas alga telah dilaksanakan dengan tujuan untuk menganalisis keanekaragaman alga makro di Taman Wisata Alam Batuputih Sulawesi Utara. Penelitian dilaksanakan di Taman Wisata Alam Batuputih, Kota Bitung dari bulan Januari sampai dengan Desember 2009. Pada lokasi penelitian dibuat 5 garis transek dengan jarak antara satu transek dengan transek berikutnya adalah 50 m. Setiap transek diambil 5 plot dengan ukuran 1 m x 1 m. Penempatan plot adalah 10 m, 20 m, 30 m, 40 m, dan 50 m dari garis pantai. Dengan demikian total plot penelitian sebanyak 50 plot. Pada setiap plot dihitung jumlah spesies alga yang ditemukan serta luas penutupannya, serta jumlah individu/koloni. Identifikasi jenis dilakukan di lapangan dengan menggunakan buku-buku identifikasi alga dan dilakukan konfirmasi di laboratorium. Hasil penelitian yang dilakukan di Taman Wisata Alam Batuputih pada 50 plot ditemukan 411 individu alga makro dengan 18 spesies yang berasal dari 3 divisi yakni Rhodophyta, Chlorophyta dan Phaeophyta. Dalam Divisi Rhodophyta dan Chlorophyta terdapat 7 spesies dengan 6 famili yang ditemukan, lebih banyak dibandingkan dengan Divisi Phaeophyta yang hanya ditemukan 4 spesies dengan 3 famili. Kata kunci: alga, biodiversitas, Taman Wisata Alam Batuputih BIODIVERSITY OF ALGAE AT BATUPUTIH TOURISM PARK, BITUNG DISTRICT ABSTRACT A research about algae diversity has been conducted to analysis macro-algae biodiversity at Batuputih Tourism Park, Bitung City, North Sulawesi from January to December 2009. At the above location, 5 line transects were made and the distance between previous and next transect was 50 m. In each transect, 5 plots were formed as representation to the the location. Plot size was 1 m x 1 m placed at 10 m, 20 m, 30 m, 40 m, and 50 m from zero point. Therefore, the total of plot in this research was 50 plots. In all plots, algae species richness, its covering and total of individuals/colony. Species identification was done in the field by using some algae identification manuals and confirmation was done at laboratory. Results of the research showed that: there were 411 individuals of algae in 50 plots at Batuputih Tourism Park. All individuals were classified into 18 species that included in 3 divisions, those were Rhodophyta, Chlorophyta and Phaeophyta. In the Division Rhodophyta and Chlorophyta, there were 7 species within 6 families, more than Division Phaeophyta that only consisted of 4 species within 3 families

African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans

BACKGROUND: Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry. METHODS: We tested for association with haplotypes at the most replicated and significant childhood-onset asthma locus at 17q12-q21 and asthma in European American and African American children. Following this, we used whole-genome sequencing data from 1060 African American and 100 European American individuals to identify novel variants on a high-risk African American-specific haplotype. We characterized these variants in silico using gene expression and ATAC-seq data from airway epithelial cells, functional annotations from ENCODE, and promoter capture (pc)Hi-C maps in airway epithelial cells. Candidate causal variants were then assessed for correlation with asthma-associated phenotypes in African American children and adults. RESULTS: Our studies revealed nine novel African-specific common variants, enriched on a high-risk asthma haplotype, which regulated the expression of GSDMA in airway epithelial cells and were associated with features of severe asthma. Using ENCODE annotations, ATAC-seq, and pcHi-C, we narrowed the associations to two candidate causal variants that are associated with features of T2 low severe asthma. CONCLUSIONS: Previously unknown genetic variation at the 17q12-21 childhood-onset asthma locus contributes to asthma severity in individuals with African ancestries. We suggest that many other population-specific variants that have not been discovered in GWAS contribute to the genetic risk for asthma and other common diseases

Alpha-anomeric configuration of GT oligodeoxynucleotide leads to loss of the specific aptameric and cytoxic properties retained by the beta-anomeric analog

3nonenoneSCAGGIANTE B; DAPAS B.; QUADRIFOGLIO FScaggiante, Bruna; Dapas, Barbara; Quadrifoglio, F