ASCA observations of the galactic bulge hard x-ray source GRS 1758--258

GRS 1758-258 is one of the few persistent hard X-ray emitters (E>100 keV) in the Galaxy. Using the ASCA satellite, we have obtained the first detailed data on GRS 1758-258 in the 1-10 keV range, where previous observations were affected by confusion problems caused by the nearby strong source GX5-1. The spectrum is well described by a power law with photon index 1.7 without strong Fe emission lines. A prominent soft excess, as observed with ROSAT when the hard X-ray flux was in a lower intensity state, was not detected. However, the presence of a soft spectral component, accounting for at most 5% of the 0.1-300 keV flux, cannot be excluded. The accurate measurement of interstellar absorption (N_H=(1.5+-0.1) x 10^22 cm -2) corresponds to an optical extinction which definitely excludes the presence of a massive companion.Comment: 7 pages, AAS latex [11pt,aaspptwo,flushrt,tighten], + 1.ps figure Accepted for pubblication in ApJ, 09 02 96 Also available at http://fy.chalmers.se/~haardt/personal/curr.html Figures 1 and 2 available upon request at [email protected]

A Lagrangian PFEM approach tothe numerical simulation of 3D large scale landslides impinging in water reservoirs

Landslides are exceptional natural hazards that can generate extensive damage to structures and infrastructures causing a large number of casualties. A particularly critical condition occurs when the landslide impinges in water reservoirs generating high waves. This work proposes a numerical tool to simulate the macroscopic behavior of a propagating landslide. The Particle Finite Element Method (PFEM) is here used and adapted to the specific case of landslide runout. The Lagrangian Navier-Stokes equations of incompressible fluids are used to describe the macroscopic landslide behavior. A rigid-visco-plastic law with a pressure dependent threshold, typical of a non-Newtonian, Bingham-like fluid, is used to characterize the constitutive behavior of the flowing material. Special attention is devoted to the definition of ad-hoc pressure-dependent slip boundary conditions at the interface between the flowing mass and the basal surface to better represent the real landslide-slope interaction. The proposed approach has been validated against numerical benchmarks and small scale experimental tests, showing a good agreement with the physical measurements. Real case scenarios have also been considered. 3D geometries of critical sites, where landslides have occurred, have been reconstructed allowing for the simulation of large scale real landslide runouts. Results are compared with post-event images and measurements, showing the accuracy and the capability of the method

Efficacy of Tuohy Needle in Oocytes Collection from Excised Mare Ovaries

Two methods have been described to recover oocytes from equine follicles in excised ovaries: aspiration and scraping. Aim of this work was to develop an effective method for collecting equine oocytes using Tuohy needle and comparing this technique to aspiration and scraping, with or without tunica albuginea removal. This hollow hypodermic needle, usually employed for inserting epidural catheters, is designed with a slightly curved tip, shaped similar to a small curette. In unpeeled ovaries, the recovery rates of Tuohy needle group was higher (P < .05) than in the 16 g needle aspiration and in the scraped ovaries (57% versus 36% and 47%) while the rate of cumulus-intact oocytes was higher than aspiration (46.9% versus 39.36%) but lower than scraping (46.97%) (P < .001). In unpeeled ovaries there was significant difference in maturation rate of oocytes recovered by Tuohy needle in respect to peeled ovaries (58.54% versus 50.17%, resp.). Combination of aspiration and scraping by Tuohy needle allows a faster and reliable collection of oocytes suitable for horse IVM

Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction

Recent studies on cull cows have shown that ovarian abnormalities, particularly ovarian insufficiency, are the main cause of reproductive failure. The aim of this study was to treat bovine ovarian failure with intraovarian administration of autologous platelet rich plasma (PRP), which is rich in growth factors, chemokines, and cytokines that could stimulate follicular growth and steroidogenesis. Twelve cows with ovarian hypofunction were enrolled in the study and they were randomly allocated in control group (CTR) and treated group (six animal for group). In the treated group, only five animals received the PRP treatment because intraovarian administration was hindered in one by a rectovaginal fistula. Animals of control group were treated by intraovarian administration of physiological solution. In the 4 weeks after PRP injection, a mild to strong increase in progesterone (PRG) concentrations was detected in four of the five cows treated. Artificial insemination (AI) resulted in four pregnancies that are still ongoing (7th month). Intraovarian administration of PRP improved ovarian function after 2 months of treatment. This effect may be due to reduction of follicular atresia or to revitalization of dormant oocytes allowing restoration of fertility

Towards the Evaluation of Recommender Systems with Impressions

In Recommender Systems, impressions are a relatively new type of information that records all products previously shown to the users. They are also a complex source of information, combining the effects of the recommender system that generated them, search results, or business rules that may select specific products for recommendations. The fact that the user interacted with a specific item given a list of recommended ones may benefit from a richer interaction signal, in which some items the user did not interact with may be considered negative interactions. This work presents a preliminary evaluation of recommendation models with impressions. First, impressions are characterized by describing their assumptions, signals, and challenges. Then, an evaluation study with impressions is described. The study's goal is two-fold: to measure the effects of impressions data on properly-tuned recommendation models using current open-source datasets and disentangle the signals within impressions data. Preliminary results suggest that impressions data and signals are nuanced, complex, and effective at improving the recommendation quality of recommenders. This work publishes the source code, datasets, and scripts used in the evaluation to promote reproducibility in the domain

Towards Recommender Systems with Community Detection and Quantum Computing

After decades of being mainly confined to theoretical research, Quantum Computing is now becoming a useful tool for solving realistic problems. This work aims to experimentally explore the feasibility of using currently available quantum computers, based on the Quantum Annealing paradigm, to build a recommender system exploiting community detection. Community detection, by partitioning users and items into densely connected clusters, can boost the accuracy of non-personalized recommendation by assuming that users within each community share similar tastes. However, community detection is a computationally expensive process. The recent availability of Quantum Annealers as cloud-based devices, constitutes a new and promising direction to explore community detection, although effectively leveraging this new technology is a long-term path that still requires advancements in both hardware and algorithms. This work aims to begin this path by assessing the quality of community detection formulated as a Quadratic Unconstrained Binary Optimization problem on a real recommendation scenario. Results on several datasets show that the quantum solver is able to detect communities of comparable quality with respect to classical solvers, but with better speedup, and the non-personalized recommendation models built on top of these communities exhibit improved recommendation quality. The takeaway is that quantum computing, although in its early stages of maturity and applicability, shows promise in its ability to support new recommendation models and to bring improved scalability as technology evolves

The ghrelin paradox in the control of equine chondrocyte function: The good and the bad

Increasing evidence suggests a role for ghrelin in the control of articular inflammatory diseases like osteoarthritis (OA). In the present study we examined the ability of ghrelin to counteract LPS-induced necrosis and apoptosis of chondrocytes and the involvement of GH secretagogue receptor (GHS-R)1a in the protective action of ghrelin. The effects of ghrelin (10-7-10-11\u202fmol/L) on equine primary cultured chondrocytes viability and necrosis in basal conditions and under LPS treatment (100\u202fng/ml) were detected by using both acridine orange/propidium iodide staining and annexin-5/propidium iodide staining. The presence of GHS-R1a on chondrocytes was detected by Western Blot. The involvement of the GHS-R1a in the ghrelin effect against LPS-induced cytotoxicity was examined by pretreating chondrocytes with D-Lys3-GHRP-6, a specific GHS-R1a antagonist, and by using des-acyl ghrelin (DAG, 10-7and 10-9\u202fmol/L) which did not recognize the GHS-R 1a. Low ghrelin concentrations reduced chondrocyte viability whereas 10-7\u202fmol/L ghrelin protects against LPS-induced cellular damage. The protective effect of ghrelin depends on the interaction with the GHS-R1a since it is significantly reduced by D-Lys3-GHRP-6. The negative action of ghrelin involves caspase activation and could be due to an interaction with a GHS-R type different from the GHS-R1a recognized by both low ghrelin concentrations and DAG. DAG, in fact, induces a dose-dependent decrease in chondrocyte viability and exacerbates LPS-induced damage. These data indicate that ghrelin protects chondrocytes against LPS-induced damage via interaction with GHS-R1a and suggest the potential utility of local GHS-R1a agonist administration to treat articular inflammatory diseases such as OA

Impressions in Recommender Systems: Present and Future

Impressions are a novel data source providing researchers and practitioners with more details about user interactions and their context. In particular, an impression contain the items shown on screen to users, alongside users' interactions toward such items. In recent years, interest in impressions has thrived, and more papers use impressions in recommender systems. Despite this, the literature does not contain a comprehensive review of the current topics and future directions. This work summarizes impressions in recommender systems under three perspectives: recommendation models, datasets with impressions, and evaluation methodologies. Then, we propose several future directions with an emphasis on novel approaches. This work is part of an ongoing review of impressions in recommender systems

Amniotic microvesicles impact hatching and pregnancy percentages of in vitro bovine embryos and blastocyst microRNA expression versus in vivo controls

Embryo development and implantation are dynamic processes, responsive to external signals, and can potentially be influenced by many environmental factors. The aims of this study were to evaluate the effects of a culture medium supplemented with amniotic-derived microvesicles (MVs) on in vitro embryo hatching after cryopreservation, and pregnancy rate following embryo transfer. In addition, miRNA profiling of blastocysts produced in vitro, with or without (control; CTR) amniotic MV supplementation, was also evaluated using blastocysts produced in vivo. In vitro embryos were cultured with and without amniotic MV supplementation. In vivo blastocysts were obtained from superovulated cows. Samples for RNA isolation were obtained from three pools of 10 embryos each (in vivo, in vitro-CTR and in vitro + MVs). Our results show that the hatching percentage of cryopreserved in vitro + MVs embryos is higher (P &lt; 0.05) than in vitro-CTR embryos and the pregnancy rate with fresh and cryopreserved in vitro + MVs embryos is higher than in vitro-CTR embryos. In addition, the analysis of differently expressed (DE) microRNAs showed that embryos produced in vivo are clearly different from those produced in vitro. Moreover, in vitro-CTR and in vitro + MVs embryos differ significantly for expression of two miRNAs that were found in higher concentrations in in vitro-CTR embryos. Interestingly, these two miRNAs were also reported in degenerated bovine embryos compared to good quality blastocysts. In conclusion, MV addition during in vitro production of embryos seems to counteract the adverse effect of in vitro culture and partially modulate the expression of specific miRNAs involved in successful embryo implantation