Bilateral femoral neck fractures due to transient osteoporosis of pregnancy: a case report

We describe a case of bilateral femoral neck fractures secondary to transient osteoporosis of pregnancy, which were diagnosed after delivery due to the desire to avoid ionising radiation. These fractures were presumed to be secondary to transient osteoporosis of pregnancy and were treated successfully with internal fixation despite delayed presentation. We discuss the role of MRI in the evaluation of hip pain in pregnancy

Some novel antimicrobial therapeutic agents for acetylcholinesterase inhibitors; synthesis of hydroxyquinoline ester involving amino acid

The aim of this work was to investigate the new effective agents candidate for treatment of the Alzheimer’s disease. So, a series of new and highly active acetylcholinesterase inhibitors derived from hydroxyquinoline ester containing amino acid were synthesized. Antibacterial activities of the molecules were studied by the well-diffusion method against Listeria monocytogenes 4b, Staphylococcus aureus, Escherichia coli, Salmonella typhi H, Brucella abortus, Staphylococcus epidermis sp., Micrococcus luteus, Shigella dysenteria type 10, Bacillus cereus, Pseudomonas putida and antifungal activity against Candida albicans. All the synthesized compounds behave as inhibitors against acetylcholinesterase enzyme. CysEs and MetEs show more inhibition potency. © 2015, Gazi University Eti Mahallesi. All rights reserved

Demographic and clinical characteristics and bone-mineral metabolism of pediatric cerebral palsy patients [Serebral palsili hastalarin klinik bulgulari ve kemik mineral metabolizmalarinin degerlendirilmesi]

The aim of the study is to evaluate clinic and demographic properties, detect bone mineral metabolism problems and raise awareness of these problems of cerebral palsy (CP) patients who are followed up in Çukurova University Pediatric Neurology Department. 102 patients aged 2-18 years who are regularly followed up in Çukurova University Pediatric Neurology Department, between January 2014-January 2015 are involved in this study. Demographic characteristics, etiologies, clinic and laboratory findings and associated problems of these patients are evaluated. Mean age of patients were 96.83 ± 53.54 months (24-207 months), male/female ratio was 1,2. 23.5% of the percents were born term and 50% patients' birth weight was above 2500 gr. Spastic Quadriplegia was the most frequent type (38.2%). Most frequent etiologic factor was natal factors (56.9%). In detailed etiologic evaluation, asphyxia (49%) and low birth weight (28.4%) were most seen. Most frequent cerebral MRI abnormality was periventricular leukomalacia (25%). Other accompanying problems were mental retardation 88.2%, speech problems (72.5%), malnutrition (67.6%), epilepsy (46.4%), visual problems (28.4%). Levels of osteocalcin, IGF-1, IGFBP-3 and PTH were better in patients who were on regular physiotherapy (p 0.05). Enough and correct sun exposure and regular, dynamic physiotherapy may improve bone health. Regular follow-up of neuromotor development in patients with complicated birth and perinatal asphyxia may prevent delayed diagnosis and treatment

Phenotypic diversity of patients diagnosed with VACTERL association

The combination of vertebral, anal, cardiac, tracheo-esophageal, renal and limb anomalies termed VACTERL association, also referred to as VATER, has been used as a clinical descriptor and more recently, a diagnosis of exclusion, for a specific group of phenotypic manifestations that have been observed to co-occur non-randomly. Though the causes remain elusive and poorly understood in most patients, VACTERL association is thought to be due to defects in early embryogenesis and is likely genetically heterogeneous. We present data on 36 patients diagnosed with VACTERL association in addition to describing the phenotypic diversity of each component feature. Unique cases in our cohort include a patient with a 498.59 kb microdeletion in the 16p11.2 region and another with a 215 kb duplication in the 3p25.2 region. Our findings expand upon the current understanding of VACTERL association and guide future research aimed at determining its etiology