Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies

Introduction Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the development of inflammation by stimulating the secretion of an adverse cytokine profile from adipose tissue. Aims The study investigated the relationship between endotoxin and various metabolic parameters of diabetic patients to determine if anti-diabetic therapies exerted a significant effect on endotoxin levels and adipocytokine profiles. Methods Fasting blood samples were collected from consenting Saudi Arabian patients (BMI: 30.2 ± (SD)5.6 kg/m2, n = 413), consisting of non-diabetics (ND: n = 67) and T2DM subjects (n = 346). The diabetics were divided into 5 subgroups based on their 1 year treatment regimes: diet-controlled (n = 36), metformin (n = 141), rosiglitazone (RSG: n = 22), a combined fixed dose of metformin/rosiglitazone (met/RSG n = 100) and insulin (n = 47). Lipid profiles, fasting plasma glucose, insulin, adiponectin, resistin, TNF-α, leptin, C-reactive protein (CRP) and endotoxin concentrations were determined. Results Regression analyses revealed significant correlations between endotoxin levels and triglycerides (R2 = 0.42; p < 0.0001); total cholesterol (R2 = 0.10; p < 0.001), glucose (R2 = 0.076; p < 0.001) and insulin (R2 = 0.032; p < 0.001) in T2DM subjects. Endotoxin showed a strong inverse correlation with HDL-cholesterol (R2 = 0.055; p < 0.001). Further, endotoxin levels were elevated in all of the treated diabetic subgroups compared with ND, with the RSG treated diabetics showing significantly lower endotoxin levels than all of the other treatment groups (ND: 4.2 ± 1.7 EU/ml, RSG: 5.6 ± 2.2 EU/ml). Both the met/RSG and RSG treated groups had significantly higher adiponectin levels than all the other groups, with the RSG group expressing the highest levels overall. Conclusion We conclude that sub-clinical inflammation in T2DM may, in part, be mediated by circulating endotoxin. Furthermore, that whilst the endotoxin and adipocytokine profiles of diabetic patients treated with different therapies were comparable, the RSG group demonstrated significant differences in both adiponectin and endotoxin levels. We confirm an association between endotoxin and serum insulin and triglycerides and an inverse relationship with HDL. Lower endotoxin and higher adiponectin in the groups treated with RSG may be related and indicate another mechanism for the effect of RSG on insulin sensitivity

Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis

Background: Little information is available on leptin concentrations in individuals with IGT. This study aims to determine and correlate leptin levels to anthropometric measures of obesity in prediabetic, (IFG and IGT), type 2 diabetic and normoglycaemic Saudis. Methods: 308 adult Saudis (healthy controls n = 80; pre-diabetes n = 86; Type 2 diabetes n = 142) participated. Anthropometric parameters were measured and fasting blood samples taken. Serum insulin was analysed, using a solid phase enzyme amplified sensitivity immunoassay and also leptin concentrations, using radio-immunoassay. The remaining blood parameters were determined using standard laboratory procedures. Results: Leptin levels of diabetic and pre-diabetic men were higher than in normoglycaemic men (12.4 [3.2–72] vs 3.9 [0.8–20.0] ng/mL, (median [interquartile range], p = 0.0001). In females, leptin levels were significantly higher in pre-diabetic subjects (14.09 [2.8–44.4] ng/mL) than in normoglycaemic subjects (10.2 [0.25–34.8] ng/mL) (p = 0.046). After adjustment for BMI and gender, hip circumference was associated with log leptin (p = 0.006 with R2 = 0.086) among all subjects. Conclusion: Leptin is associated with measures of adiposity, hip circumference in particular, in the non-diabetic state among Saudi subjects. The higher leptin level among diabetics and pre-diabetics is not related to differences in anthropometric measures of obesity

Population's perspectives toward biobanks in scientific research: a study from Jordan.

BackgroundBiobanks (biorepositories) were established to compile collected bio-specimens for future research and usage. The collection/storage of bio-specimens triggers several social, legal, and ethical implications where public attitudes can represent the core measurement/parameter in defining the most acceptable practices and ethical approaches when dealing with biobanks.AimThe aim of this study was to explore and understand population's perspectives, expectations, and concerns toward biobanks in Jordan.MethodsA cross-sectional survey that included closed-ended questions was distributed among Jordanians. A total of 500 participants who are representative of the Jordanian population were included in this study.ResultsThere was overwhelming support (&gt;85%) for the establishment of biobanks in Jordan, and most of the participants agreed on the importance of biobanks and samples' donation for promoting medical research. Enthusiasm in biobanking participation was associated with the sociodemographic characteristics of participants including age, educational level, and previous knowledge of biobanks. Moreover, considering sample donation as a religiously good deed appeared to have the strongest positive correlation with willingness to donate bio-specimens for future research. Also, participants' trust in medical and research services, especially the protection of their privacy and confidentiality, was the most critical concern when they decided to participate in biobanks.ConclusionPopulation's attitude toward biobanks in Jordan was positive and promising, and can encourage the future establishment of different biobanks. It is also necessary to take into consideration certain sociodemographic characteristics when discussing specific information with potential biobanks' donors

Smart Flow Steering Agent for End-to-End Delay Improvement in Software-Defined Networks

لضمان الإستجابة للخطأ والإدارة الموزعة، يتم استخدام البروتوكولات الموزعة كأحد المفاهيم المعمارية الرئيسية التي تتضمنها شبكة الإنترنت. ومع ذلك، يمكن التغلب على عدم الكفاءة وعدم الاستقرار والقصور بمساعدة بنية الشبكات الجديدة التي تسمى الشبكات المعرفة بالبرمجيات SDN. الخاصية الرئيسية لهذه المعمارية هي فصل مستوى التحكم عن مستوى البيانات. إن تقليل التصادم سيؤدي إلى تحسين سرعة الإستجابة وزيادة البيانات المرسلة بصورة صحيحة، لهذا السبب يجب أن يكون هناك توزيع متجانس للحمل المروري عبر مسارات الشبكة المختلفة. تقدم هذه الورقة البحثية أداة توجيه ذكية SFSA لتوجيه تدفق البيانات بناءاً على ظروف الشبكة الحالية. لتحسين الإنتاجية وتقليل زمن الوصول، فإن الخوارزمية المقترحة SFSA تقوم بتوزيع حركة مرور البيانات داخل الشبكة على مسارات مناسبة ، بالإضافة إلى الإشراف على الإرتباطات التشعبية وحمل مسارات نقل البيانات. تم استخدام سيناريو خوارزمية توجيه شجرة الامتداد الدنياMST وأخرى مع خوارزمية التوجيه المعروفة بفتح أقصر مسار أولاً OSPF لتقييم جودة الخوارمية المقترحة SFSA . على سبيل المقارنة ، بالنسبة لخوارزميات التوجيه المذكروة آنفاً ، فقد حققت استراتيجيةSFSA المقترحة انخفاضاً بنسبة 2٪ في معدل ضياع حزم البيانات PDR ، وبنسبة تتراوح بين 15-45٪ في سرعة إستلام البيانات من المصدر إلى الالوجهة النهائية لحزمة البيانات وكذلك انخفاض بنسبة 23 ٪ في زمن رحلة ذهاب وعودة RTT . تم استخدام محاكي Mininet ووحدة التحكم POX لإجراء المحاكاة. ميزة أخرى من SFSA على MST و OSPF هي أن وقت التنفيذ والاسترداد لا يحمل تقلبات. يتقوم أداة التوجيه الذكية المقترحة في هذه الورقة البحثية من فتح أفقاً جديداً لنشر أدوات ذكية جديدة في شبكة SDN تعزز قابلية برمجة الشبكات وإدارتها .To ensure fault tolerance and distributed management, distributed protocols are employed as one of the major architectural concepts underlying the Internet. However, inefficiency, instability and fragility could be potentially overcome with the help of the novel networking architecture called software-defined networking (SDN). The main property of this architecture is the separation of the control and data planes. To reduce congestion and thus improve latency and throughput, there must be homogeneous distribution of the traffic load over the different network paths. This paper presents a smart flow steering agent (SFSA) for data flow routing based on current network conditions. To enhance throughput and minimize latency, the SFSA distributes network traffic to suitable paths, in addition to supervising link and path loads. A scenario with a minimum spanning tree (MST) routing algorithm and another with open shortest path first (OSPF) routing algorithms were employed to assess the SFSA. By comparison, to these two routing algorithms, the suggested SFSA strategy determined a reduction of 2% in packets dropped ratio (PDR), a reduction of 15-45% in end-to-end delay according to the traffic produced, as well as a reduction of 23% in round trip time (RTT). The Mininet emulator and POX controller were employed to conduct the simulation. Another advantage of the SFSA over the MST and OSPF is that its implementation and recovery time do not exhibit fluctuations. The smart flow steering agent will open a new horizon for deploying new smart agents in SDN that enhance network programmability and management

Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population

Aims Resistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease. Methods One hundred and fourteen Saudi Arabian patients (male: female ratio 46:68; age 51.4 (mean ± SD)11.7 years; median and range: 45.59 (11.7) years and BMI: 27.1 (mean ± SD) 8.1 Kgm2 median and range: 30.3 (6.3) were studied. Serum resistin and C-reactive protein (CRP), a marker of inflammation CRP levels, were measured in all subjects. (35 patients had type 2 diabetes mellitus (T2DM); 22 patients had coronary heart disease (CHD). Results Serum resistin levels were 1.2-fold higher in type 2 diabetes and 1.3-fold higher in CHD than in controls (p = 0.01). In addition, CRP was significantly increased in both T2DM and CHD patients (p = 0.007 and p = 0.002 respectively). The use of regression analysis also determined that serum resistin correlated with CRP levels (p = 0.04, R2 0.045). Conclusion The findings from this study further implicate resistin as a circulating protein associated with T2DM and CHD. In addition this study also demonstrates an association between resistin and CRP, a marker of inflammation in type 2 diabetic patients

Studying Relationship between the Approach of Business Reengineering and Performance "An Empirical Study on Food Companies Listed at the Amman Stock Exchange" )

In Jordan, the changing dynamics of the industrial companies in general and food industry specially, forced players at all levels to re-engineering their business companies. This research aims to study the response and support food companies to the concept of business re-engineering. To measure the extent of support managements to apply the concept of re-engineering, the extent of availability requirements for the application of process re-engineering, and, to measure the extent of the application of re-engineering processes and its impact on the financial performance of food companies listed at the Amman Stock Exchange.The researchers studied the intellectual frame and scientific rooting for business reengineering to achieve study objectives. They have designed a questionnaire aimed to execute of the study problem variables in order to test hypotheses. The research suggested the following results: application of re-engineering have benefits for companies that are applied. It could improving their competitive, increasing market share, productions, efficiency, and cost reduction. There are a statistically significant relationship in the attitudes of the study sample towards the response and support management of companies, the availability of requirements of the application, and the impact of the application of business re-engineering to the performance on food companies. It recommended that reengineering process remains effective tools for companies needing to operate as effectively and efficiently. Companies are required to reengineering their business processes in order to achieve best performance and growth. Keywords:  Business Process, Business Process Re-engineering (BPR), Companies Performance, Information Technology, Evaluation Process

The oscar, Astronotus ocellatus (Agassiz, 1831) (Cichlidae): a deliberate aquarium trade introduction in the Euphrates River, Iraq

The first record of a single specimen of oscar, Astronotus ocellatus, native to Amazon basin of Peru, Colombia and Brazil, is reported from the inland waters of Iraq. The specimen was caught from one of the branches of the Euphrates River to the east of the Barnun city, ca. 5 km to the NW of Hilla city in Babylon Province in central Iraq in December 2021 using rod and line. The capture of a sub-adult specimen, 186.7 mm in total length, indicates the first record of another aquarium fish species in the freshwater system of Iraq. The aquarium trade pathway is the suspected factor for the presence of this species in the Iraqi freshwater area

The oscar, Astronotus ocellatus (Agassiz, 1831) (Cichlidae): a deliberate aquarium trade introduction in the Euphrates River, Iraq

The first record of a single specimen of oscar, Astronotus ocellatus, native to Amazon basin of Peru, Colombia and Brazil, is reported from the inland waters of Iraq. The specimen was caught from one of the branches of the Euphrates River to the east of the Barnun city, ca. 5 km to the NW of Hilla city in Babylon Province in central Iraq in December 2021 using rod and line. The capture of a sub-adult specimen, 186.7 mm in total length, indicates the first record of another aquarium fish species in the freshwater system of Iraq. The aquarium trade pathway is the suspected factor for the presence of this species in the Iraqi freshwater area

Discovering Design Principles for Health Behavioral Change Support Systems: A Text Mining Approach

Behavioral Change Support Systems (BCSSs) aim to change users’ behavior and lifestyle. These systems have been gaining popularity with the proliferation of wearable devices and recent advances in mobile technologies. In this article, we extend the existing literature by discovering design principles for health BCSSs based on a systematic analysis of users’ feedback. Using mobile diabetes applications as an example of Health BCSSs, we use topic modeling to discover design principles from online user reviews. We demonstrate the importance of the design principles through analyzing their existence in users’ complaints. Overall, the results highlight the necessity of going beyond the techno-centric approach used in current practice and incorporating the social and organizational features into persuasive systems design, as well as integrating with medical devices and other systems in their usage context

Security policy compliance: User acceptance perspective

Information security policy compliance is one of the key concerns that face organizations today. Although, technical and procedural security measures help improve information security, there is an increased need to accommodate human, social and organizational factors. While employees are considered the weakest link in information security domain, they also are assets that organizations need to leverage effectively. Employees\u27 compliance with Information Security Policies (ISPs) is critical to the success of an information security program. The purpose of this research is to develop a measurement tool that provides better measures for predicting and explaining employees\u27 compliance with ISPs by examining the role of information security awareness in enhancing employees\u27 compliance with ISPs. The study is the first to address compliance intention from a users\u27 perspective. Overall, analysis results indicate strong support for the proposed instrument and represent an early confirmation for the validation of the underlying theoretical model