Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis

Background: Little information is available on leptin concentrations in individuals with IGT. This study aims to determine and correlate leptin levels to anthropometric measures of obesity in prediabetic, (IFG and IGT), type 2 diabetic and normoglycaemic Saudis. Methods: 308 adult Saudis (healthy controls n = 80; pre-diabetes n = 86; Type 2 diabetes n = 142) participated. Anthropometric parameters were measured and fasting blood samples taken. Serum insulin was analysed, using a solid phase enzyme amplified sensitivity immunoassay and also leptin concentrations, using radio-immunoassay. The remaining blood parameters were determined using standard laboratory procedures. Results: Leptin levels of diabetic and pre-diabetic men were higher than in normoglycaemic men (12.4 [3.2–72] vs 3.9 [0.8–20.0] ng/mL, (median [interquartile range], p = 0.0001). In females, leptin levels were significantly higher in pre-diabetic subjects (14.09 [2.8–44.4] ng/mL) than in normoglycaemic subjects (10.2 [0.25–34.8] ng/mL) (p = 0.046). After adjustment for BMI and gender, hip circumference was associated with log leptin (p = 0.006 with R2 = 0.086) among all subjects. Conclusion: Leptin is associated with measures of adiposity, hip circumference in particular, in the non-diabetic state among Saudi subjects. The higher leptin level among diabetics and pre-diabetics is not related to differences in anthropometric measures of obesity

Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population

Aims Resistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease. Methods One hundred and fourteen Saudi Arabian patients (male: female ratio 46:68; age 51.4 (mean ± SD)11.7 years; median and range: 45.59 (11.7) years and BMI: 27.1 (mean ± SD) 8.1 Kgm2 median and range: 30.3 (6.3) were studied. Serum resistin and C-reactive protein (CRP), a marker of inflammation CRP levels, were measured in all subjects. (35 patients had type 2 diabetes mellitus (T2DM); 22 patients had coronary heart disease (CHD). Results Serum resistin levels were 1.2-fold higher in type 2 diabetes and 1.3-fold higher in CHD than in controls (p = 0.01). In addition, CRP was significantly increased in both T2DM and CHD patients (p = 0.007 and p = 0.002 respectively). The use of regression analysis also determined that serum resistin correlated with CRP levels (p = 0.04, R2 0.045). Conclusion The findings from this study further implicate resistin as a circulating protein associated with T2DM and CHD. In addition this study also demonstrates an association between resistin and CRP, a marker of inflammation in type 2 diabetic patients

Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies

Introduction Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the development of inflammation by stimulating the secretion of an adverse cytokine profile from adipose tissue. Aims The study investigated the relationship between endotoxin and various metabolic parameters of diabetic patients to determine if anti-diabetic therapies exerted a significant effect on endotoxin levels and adipocytokine profiles. Methods Fasting blood samples were collected from consenting Saudi Arabian patients (BMI: 30.2 ± (SD)5.6 kg/m2, n = 413), consisting of non-diabetics (ND: n = 67) and T2DM subjects (n = 346). The diabetics were divided into 5 subgroups based on their 1 year treatment regimes: diet-controlled (n = 36), metformin (n = 141), rosiglitazone (RSG: n = 22), a combined fixed dose of metformin/rosiglitazone (met/RSG n = 100) and insulin (n = 47). Lipid profiles, fasting plasma glucose, insulin, adiponectin, resistin, TNF-α, leptin, C-reactive protein (CRP) and endotoxin concentrations were determined. Results Regression analyses revealed significant correlations between endotoxin levels and triglycerides (R2 = 0.42; p < 0.0001); total cholesterol (R2 = 0.10; p < 0.001), glucose (R2 = 0.076; p < 0.001) and insulin (R2 = 0.032; p < 0.001) in T2DM subjects. Endotoxin showed a strong inverse correlation with HDL-cholesterol (R2 = 0.055; p < 0.001). Further, endotoxin levels were elevated in all of the treated diabetic subgroups compared with ND, with the RSG treated diabetics showing significantly lower endotoxin levels than all of the other treatment groups (ND: 4.2 ± 1.7 EU/ml, RSG: 5.6 ± 2.2 EU/ml). Both the met/RSG and RSG treated groups had significantly higher adiponectin levels than all the other groups, with the RSG group expressing the highest levels overall. Conclusion We conclude that sub-clinical inflammation in T2DM may, in part, be mediated by circulating endotoxin. Furthermore, that whilst the endotoxin and adipocytokine profiles of diabetic patients treated with different therapies were comparable, the RSG group demonstrated significant differences in both adiponectin and endotoxin levels. We confirm an association between endotoxin and serum insulin and triglycerides and an inverse relationship with HDL. Lower endotoxin and higher adiponectin in the groups treated with RSG may be related and indicate another mechanism for the effect of RSG on insulin sensitivity

Using a Proposed Program Based on Johannes Itten’s Theory of Color in the Development of Color Culture among Faculty of Early-Childhood Education Students

The current study was prepared on the basis that color is one of the most important visual elements of the creativity of the artistic work due to its role in highlighting aesthetic and expressive values with the diversity of its color relations as well as its ability to show ideas and to increase attention, in addition to the use of color to show form and to increase motivation for learning. This study aimed to investigate the effectiveness of a proposed program based on Johannes Itten’s theory of color to teach color to the students of the Faculty of Early Childhood Education in the development of their color culture. The material and instruments of the study included a proposed program based only on watercolors, in addition to a performance scale for color culture. The sample of the study consisted of (30) students of the third year at the Faculty of Early Childhood Education. The study findings showed that there are statistically significant differences between the mean scores obtained by the study participants on the pre and post administrations of the performance scale of color culture in favor of the post-administration. Thus, the present study proved the effectiveness of the proposed program in the development of the color culture among the student-teacher at the Faculty of Early Childhood Education

Various Factors Affecting Students Performances In A Saudi Medical School

Objective: There are various demographic and educational factors that affect the academic performance of undergraduate medical students. The objective of this study is to identify these factors and correlate them to the GPA of the students. Methods: A cross-sectional study design utilizing grade point averages (GPAs) of two cohorts of students in both levels of the pre-clinical phase. In addition, self-administered questionnaire was used to evaluate the effect of these factors on students with poor and good cumulative GPA. Results: Among the various factors studied, gender, marital status, and the transportation used to reach the faculty significantly affected academic performance of students. Students with a cumulative GPA of 3.0 or greater significantly differed than those with a GPA of less than 3.0 being higher in female students, in married students, and type of transportation used to reach the college. Factors including age, educational factors, and type of transportation used have shown to create a significant difference in GPA between male and females. Conclusion: Factors such as age, gender, marital status, learning resources, study time, and the transportation used have been shown to significantly affect medical student GPA as a whole batch as well as when they are tested for gender

Recursive residuals for linear mixed models

This paper presents and extends the concept of recursive residuals and their estimation to an important class of statistical models, Linear Mixed Models (LMM). Recurrence formulae are developed and recursive residuals are defined. Recursive computable expressions are also developed for the model’s likelihood, together with its derivative and information matrix. The theoretical framework for developing recursive residuals and their estimation for LMM varies with the estimation method used, such as the fitting-of-constants or the Best Linear Unbiased Predictor method. These methods are illustrated through application to an LMM example drawn from a published study. Model fit is assessed through a graphical display of the developed recursive residuals and their Cumulative Sums

Dental Anxiety and Fear among Patients in Jazan, Kingdom of Saudi Arabia: A Cross-sectional Study

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Criterion for polynomial solutions to a class of linear differential equation of second order

We consider the differential equations y''=\lambda_0(x)y'+s_0(x)y, where \lambda_0(x), s_0(x) are C^{\infty}-functions. We prove (i) if the differential equation, has a polynomial solution of degree n >0, then \delta_n=\lambda_n s_{n-1}-\lambda_{n-1}s_n=0, where \lambda_{n}= \lambda_{n-1}^\prime+s_{n-1}+\lambda_0\lambda_{n-1}\hbox{and}\quad s_{n}=s_{n-1}^\prime+s_0\lambda_{k-1},\quad n=1,2,.... Conversely (ii) if \lambda_n\lambda_{n-1}\ne 0 and \delta_n=0, then the differential equation has a polynomial solution of degree at most n. We show that the classical differential equations of Laguerre, Hermite, Legendre, Jacobi, Chebyshev (first and second kind), Gegenbauer, and the Hypergeometric type, etc, obey this criterion. Further, we find the polynomial solutions for the generalized Hermite, Laguerre, Legendre and Chebyshev differential equations.Comment: 12 page

Prevalence, Awareness, Treatment, and Control of Hypertension among Saudi Adult Population: A National Survey

This cross-sectional study aimed at estimating prevalence, awareness, treatment, control, and predictors of hypertension among Saudi adult population. Multistage stratified sampling was used to select 4758 adult participants. Three blood pressure measurements using an automatic sphygmomanometer, sociodemographics, and antihypertensive modalities were obtained. The overall prevalence of hypertension was 25.5%. Only 44.7% of hypertensives were aware, 71.8% of them received pharmacotherapy, and only 37.0% were controlled. Awareness was significantly associated with gender, age, geographical location, occupation, and comorbidity. Applying drug treatment was significantly more among older patients, but control was significantly higher among younger patients and patients with higher level of physical activity. Significant predictors of hypertension included male gender, urbanization, low education, low physical activity, obesity, diabetes, and hypercholesterolemia. In conclusion prevalence is high, but awareness, treatment, and control levels are low indicating a need to develop a national program for prevention, early detection, and control of hypertension

Perception of Saudi Mothers about Maxillary Midline Diastemas among Children with Mixed Dentition- A Cross-sectional Study

Introduction: Maxillary anterior spacing or midline diastema is the most frequently seen aesthetic concern among children, which can be quite challenging for the clinician to manage. There can be a significant disparity in the aesthetic perception from person to person and is greatly influenced by their personal experience and social environment. Aim: This study investigated the aesthetic perceptions of Saudi mothers to various Maxillary Midline Diastemas (MMDs) in mixed dentition. Materials and Methods: A cross-sectional study using structured questionnaire was employed for Saudi mothers chosen by stratified-cluster random sampling technique over a period of eight months (November 2016 to June 2017). The questionnaire assessed their perception about various MMDs using photographs and the source of information about MMDs. Data were statistical analysed (SPSS version 20) using the Chi-square test, with the level of significance set at p-value <0.05. Results: The sample consisted of 300 Saudi mothers with a response rate of 86.2%. The maximum mean score was 4.80±0.20 for the MMD photograph showing central incisor tooth discrepancy which the mothers perceived to be the most unpleasant (81%). The very unpleasant perception from the mothers’ perception for group D and B showing ugly duckling stage was (55%) and thumb sucking habit (33%), respectively. The MMD photograph showing high frenum attachment was perceived by 51% of the mothers to be unpleasant and 7% as very unpleasant. Moreover, on comparison it showed the least mean score of 3.65±0.41. Conclusion: The perception of Saudi mothers to various types of MMDs was found to be aesthetically unpleasant. Early detection of the MMDs by the Saudi mothers and intervention by the dental specialist can reduce the progression of the prevailing condition to a severe malocclusion