On some Graphs with a Unique Perfect Matching

We show that deciding whether a given graph $G$ of size $m$ has a unique perfect matching as well as finding that matching, if it exists, can be done in time $O(m)$ if $G$ is either a cograph, or a split graph, or an interval graph, or claw-free. Furthermore, we provide a constructive characterization of the claw-free graphs with a unique perfect matching

Analysing central metabolism in ultra-high resolution: at the crossroads of carbon and nitrogen

BACKGROUND: Cancer cell metabolism can be characterised by adaptive metabolic alterations, which support abnormal proliferative cell growth with high energetic demand. De novo nucleotide biosynthesis is essential for providing nucleotides for RNA and DNA synthesis, and drugs targeting this biosynthetic pathway have proven to be effective anticancer therapeutics. Nevertheless, cancers are often able to circumvent chemotherapeutic interventions and become therapy resistant. Our understanding of the changing metabolic profile of the cancer cell and the mode of action of therapeutics is dependent on technological advances in biochemical analysis. SCOPE OF REVIEW: This review begins with information about carbon- and nitrogen-donating pathways to build purine and pyrimidine moieties in the course of nucleotide biosynthesis. We discuss the application of stable isotope resolved metabolomics to investigate the dynamics of cancer cell metabolism and outline the benefits of high-resolution accurate mass spectrometry, which enables multiple tracer studies. CONCLUSION: With the technological advances in mass spectrometry that allow for the analysis of the metabolome in high resolution, the application of stable isotope resolved metabolomics has become an important technique in the investigation of biological processes. The literature in the area of isotope labelling is dominated by (13)C tracer studies. Metabolic pathways have to be considered as complex interconnected networks and should be investigated as such. Moving forward to simultaneous tracing of different stable isotopes will help elucidate the interplay between carbon and nitrogen flow and the dynamics of de novo nucleotide biosynthesis within the cell

Cross-sectoral resource management: How forest management alternatives affect the provision of biomass and other ecosystem services

Integrated forest management is faced with the challenge that the contribution of forests to economic and ecological planning targets must be assessed in a socio-ecological system context. This paper introduces a way to model spatio-temporal dynamics of biomass production at a regional scale in order to derive land use strategies that enhance biomass provision and avoid trade-offs for other ecosystem services. The software platform GISCAME was employed to bridge the gap between local land management decisions and regional planning by linking growth and yield models with an integrative mesoscale modeling and assessment approach. The model region is located in Saxony, Germany. Five scenarios were simulated, which aimed at testing different alternatives for adapted land use in the context of climate change and increasing biomass demand. The results showed, for example, that forest conversion towards climate-change-adapted forest types had positive effects on ecological integrity and landscape aesthetics. In contrast, negative impacts on landscape aesthetics must be expected if agricultural sites were converted into short rotation coppices. Uncertainties with stem from assumptions regarding growth and yield models were discussed. Future developmental steps which consider, for example, accessibility of the resources were identified

Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis

The aims of the study were to meet the demand of new tubulin antagonists with fewer side effects by characterizing the antiangiogenic properties of the experimental compound spongistatin 1, and to elucidate nonmitotic mechanisms by which tubulin antagonists inhibit angiogenesis. Although tubulin-inhibiting drugs and their antiangiogenic properties have been investigated for a long time, surprisingly little is known about their underlying mechanisms of action. Antiangiogenic effects of spongistatin 1 were investigated in endothelial cells in vitro, including functional cell-based assays, live-cell imaging, and a kinome array, and in the mouse cornea pocket assay in vivo. Spongistatin 1 inhibited angiogenesis at nanomolar concentrations (IC50: cytotoxicity>50 nM, proliferation 100 pM, migration 1.0 nM, tube formation 1.0 nM, chemotaxis 1.0 nM, aortic ring sprouting 500 pM, neovascularization in vivo 10 μg/kg). Further, a kinome array and validating data showed that spongistatin 1 inhibits the phosphorylation activity of protein kinase Cα (PKCα), an essential kinase in angiogenesis, and its translocation to the membrane. Thus, we conclude that PKCα might be an important target for the antiangiogenic effects of tubulin antagonism. In addition, the data from the kinase array suggest that different tubulin antagonists might have individual intracellular actions.—Rothmeier, A. S., Ischenko, I., Joore, J., Garczarczyk, D., Fu¨rst, R., Bruns, C. J., Vollmar, A. M., Zahler, S. Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis

A possible phase dependent absorption feature in the transient X-ray pulsar SAX J2103.5+4545

We present an X-ray spectral and timing analysis of two $NuSTAR$ observations of the transient Be X-ray binary SAX J2103.5+4545 during its April 2016 outburst, which was characterized by the highest flux since $NuSTAR$'s launch. These observations provide detailed hard X-ray spectra of this source during its bright precursor flare and subsequent fainter regular outburst for the first time. In this work, we model the phase-averaged spectra for these observations with a negative and positive power law with an exponential cut-off (NPEX) model and compare the pulse profiles at different flux states. We found that the broad-band pulse profile changes from a three peaked pulse in the first observation to a two peaked pulse in the second observation, and that each of the pulse peaks has some energy dependence. We also perform pulse-phase spectroscopy and fit phase-resolved spectra with NPEX to evaluate how spectral parameters change with pulse phase. We find that while the continuum parameters are mostly constant with pulse phase, a weak absorption feature at ~12 keV that might, with further study, be classified as a cyclotron line, does show strong pulse phase dependence.Comment: 10 pages, 7 figures, accepted by ApJ, acknowledgements update

Communication of higher education institutions: Historical developments and changes over the past decade

Higher education institutions (HEIs) are pivotal organizations in modern societies. Over the past decades, the higher education sector has expanded considerably in countries across the world, with many newly founded colleges and universities and rapid increases in student enrollment and research output. In addition, new public management reforms and a growing need for societal legitimation have led many HEIs to establish or enlarge their communication departments, pursue branding and reputation management, and professionalize their communication efforts across various channels. Although a growing body of literature has shed light on how HEIs engage in public relations (PR) and science communication, we know little about how their communication has developed over time and in relation to the fundamental transformations in higher education systems and the media landscape in recent years, decades, and even centuries. Most existing sketches of such historical developments have focused on one country – as is typical for histories of PR in general – and have been dedicated to the second half of the 20th century. In contrast, the early beginnings of university communication since the late 19th century and recent trends in the past decade have been little researched. This guest editorial and the contributions of this Thematic Section on Changing Communication of Higher Education Institutions address these gaps in research and together shed light on developments in different European countries, as well as in the U. S

PG 1610+062: a runaway B star challenging classical ejection mechanisms

Hypervelocity stars are rare objects, mostly main-sequence (MS) B stars, traveling so fast that they will eventually escape from the Milky Way. Recently, it has been shown that the popular Hills mechanism, in which a binary system is disrupted via a close encounter with the supermassive black hole at the Galactic center, may not be their only ejection mechanism. The analyses of Gaia data ruled out a Galactic center origin for some of them, and instead indicated that they are extreme disk runaway stars ejected at velocities exceeding the predicted limits of classical scenarios (dynamical ejection from star clusters or binary supernova ejection). We present the discovery of a new extreme disk runaway star, PG 1610+062, which is a slowly pulsating B star bright enough to be studied in detail. A quantitative analysis of spectra taken with ESI at the Keck Observatory revealed that PG 1610+062 is a late B-type MS star of 4–5 M⊙with low projected rotational velocity. Abundances (C, N, O, Ne, Mg, Al, Si, S, Ar, and Fe) were derived differentially with respect to the normal B star HD 137366 and indicate that PG 1610+062 is somewhat metal rich. A kinematic analysis, based on our spectrophotometric distance (17.3 kpc) and on proper motions from Gaia’s second data release, shows that PG 1610+062 was probably ejected from the Carina-Sagittarius spiral arm at a velocity of 550 ± 40 km s^(−1), which is beyond the classical limits. Accordingly, the star is in the top five of the most extreme MS disk runaway stars and is only the second among the five for which the chemical composition is known

Higher Education Institutions on Facebook, Instagram, and Twitter: Comparing Swiss Universities’ Social Media Communication

Public communication has become more important to higher education institutions (HEIs), with many HEIs using social media to communicate with stakeholders. However, scholarship on the subject is scarce and mainly based on single-platform studies and small datasets. Therefore, we conducted a cross-platform study to examine the communication of all Swiss HEIs on Facebook, Instagram, and Twitter. The results were based on two datasets: an automated analysis on data for all Swiss HEIs (n = 42) and their social media accounts from 2004 to 2021 (337,232 posts from 207 accounts), and a manual content analysis on 1,500 posts per platform. By including all HEIs in one country, this study allowed for a comparison of the results by HEI type: universities of applied sciences, universities of teacher education, and research universities. Results show that, in recent years, HEI communication increased on Instagram, but not on Facebook or Twitter. Twitter was used the most by research universities, while most Instagram and Facebook posts were from universities of applied sciences. Universities of teacher education were least active across all platforms. The content of communication across all HEI types was primarily self-referential. Our analysis of how well HEIs used the affordances of social media communication relative to hypertextuality and multimodality revealed a generally high level of adaption. Moreover, our data showed no substantial impact of the Covid-19 pandemic on posting activities and engagement with social media posts by HEIs for the two first years of the pandemic

Standing osteosynthesis of an accessory carpal bone fracture in a Warmblood mare with a 6‐hole 3.5 talonavicular fusion plate and 3.5‐mm screws

A 9-year-old Warmblood, high-level showjumping mare sustained an acute, closed, vertical, comminuted fracture of the left accessory carpal bone (ACB) during a fall. The fracture was repaired under standing sedation and local anaesthesia, using a 6-hole APTUS® 3.5 TFP and 5 × 3.5-mm self-tapping TriLock© screws. The mare recovered from surgery without complications. Upon follow-up examination 9 months post-operatively the mare was sound in all gaits and back to full athletic activity. The ACB fracture had completely healed. The displaced dorsoproximal fracture fragment was in a stationary position and there was evidence of mild nonprogressive osteoarthritis of the antebrachiocarpal joint