514 research outputs found
Declination dependence of the cosmic-ray flux at extreme energies
We study the large-scale distribution of the arrival directions of the
highest energy cosmic rays observed by various experiments. Despite clearly
insufficient statistics, we find a deficit of cosmic rays at energies higher
than 10^{20} eV from a large part of the sky around the celestial North Pole.
We speculate on possible explanations of this feature.Comment: 5 pages, 4 figures; v2: 11 pages, 4 figures, title changed (to avoid
confusion with the Southern hemisphere), analysis extended, more data
included, results unchanged; to be published in JCA
Ultra-High Energy Cosmic Ray Nuclei from Individual Magnetized Sources
We investigate the dependence of composition, spectrum and angular
distributions of ultra-high energy cosmic rays above 10^19 eV from individual
sources on their magnetization. We find that, especially for sources within a
few megaparsecs from the observer, observable spectra and composition are
severely modified if the source is surrounded by fields of ~ 10^-7 Gauss on
scales of a few megaparsecs. Low energy particles diffuse over larger distances
during their energy loss time. This leads to considerable hardening of the
spectrum up to the energy where the loss distance becomes comparable to the
source distance. Magnetized sources thus have very important consequences for
observations, even if cosmic rays arrive within a few degrees from the source
direction. At the same time, details in spectra and chemical composition may be
intrinsically unpredictable because they depend on the unknown magnetic field
structure. If primaries are predominantly nuclei of atomic mass A accelerated
up to a maximum energy E_max with spectra not much softer than E^-2, secondary
protons from photo-disintegration can produce a conspicuous peak in the
spectrum at energy ~ E_max/A. A related feature appears in the average mass
dependence on energy.Comment: 15 pages, 16 ps figures, published version with minor changes, see
http://stacks.iop.org/1475-7516/2004/i=08/a=01
Temporal trends in frequency, type and severity of myopia and associations with key environmental risk factors in the UK: Findings from the UK Biobank Study
This study investigated temporal trends in the epidemiology of primary myopia and associations with key environmental risk factors in a UK population. Data were collected at recruitment (non-cycloplegic autorefraction, year of birth, sex, ethnicity, highest educational attainment, reason and age of first wearing glasses and history of eye disease) from 107,442 UK Biobank study participants aged 40 to 69 years, born between 1939 and 1970. Myopia was defined as mean spherical equivalent (MSE) ≤-1 dioptre (D). Temporal changes in myopia frequency by birth cohort (5-year bands using date of birth) and associations with environmental factors were analysed, distinguishing both type (childhood-onset, <18 years versus adult-onset) and severity (three categories: low -1.00 to -2.99D, moderate -3.00 to -5.99D or high ≥-6.00D). Overall myopia frequency increased from 20.0% in the oldest cohort (births 1939-1944) to 29.2% in the youngest (1965-1970), reflecting a relatively higher increase in frequency of adult-onset and low myopia. Childhood-onset myopia peaked in participants born in 1950-54, adult-onset myopia peaked in the cohort born a decade later. The distribution of MSE only shifted for childhood-onset myopia (median: -3.8 [IQR -2.4, -5.4] to -4.4 [IQR -3.0, -6.2]). The magnitude of the association between higher educational attainment (proxy for educational intensity) and myopia overall increased over time (adjusted Odds Ratio (OR) 2.7 [2.5, 2.9] in the oldest versus 4.2 [3.3, 5.2] in the youngest cohort), being substantially greater for childhood-onset myopia (OR 3.3 [2.8, 4.0] to 8.0 [4.2, 13]). Without delineating childhood-onset from adult-onset myopia, important temporal trends would have been obscured. The differential impact of educational experience/intensity on both childhood-onset and high myopia, amplified over time, suggests a cohort effect in gene-environment interaction with potential for increasing myopia frequency if increasing childhood educational intensity is unchecked. However, historical plateauing of myopia frequency does suggest some potential for effective intervention
Gamma-Ray Constraints on Maximum Cosmogenic Neutrino Fluxes and UHECR Source Evolution Models
The dip model assumes that the ultra-high energy cosmic rays (UHECRs) above
10 eV consist exclusively of protons and is consistent with the spectrum
and composition measure by HiRes. Here we present the range of cosmogenic
neutrino fluxes in the dip-model which are compatible with a recent
determination of the extragalactic very high energy (VHE) gamma-ray diffuse
background derived from 2.5 years of Fermi/LAT data. We show that the largest
fluxes predicted in the dip model would be detectable by IceCube in about 10
years of observation and are within the reach of a few years of observation
with the ARA project. In the incomplete UHECR model in which protons are
assumed to dominate only above 10 eV, the cosmogenic neutrino fluxes
could be a factor of 2 or 3 larger. Any fraction of heavier nuclei in the UHECR
at these energies would reduce the maximum cosmogenic neutrino fluxes. We also
consider here special evolution models in which the UHECR sources are assumed
to have the same evolution of either the star formation rate (SFR), or the
gamma-ray burst (GRB) rate, or the active galactic nuclei (AGN) rate in the
Universe and found that the last two are disfavored (and in the dip model
rejected) by the new VHE gamma-ray background.Comment: 19 pages, 16 figures, JHEP3.cls needed to typese
Upper Bounds on the Neutrino-Nucleon Inelastic Cross Section
Extraterrestrial neutrinos can initiate deeply developing air showers, and
those that traverse the atmosphere unscathed may produce cascades in the ice or
water. Up to now, no such events have been observed. This can be translated
into upper limits on the diffuse neutrino flux. On the other hand, the
observation of cosmic rays with primary energies > 10^{10} GeV suggests that
there is a guaranteed flux of cosmogenic neutrinos, arising from the decay of
charged pions (and their muon daughters) produced in proton interactions with
the cosmic microwave background. In this work, armed with these cosmogenic
neutrinos and the increased exposure of neutrino telescopes we bring up-to-date
model-independent upper bounds on the neutrino-nucleon inelastic cross section.
Uncertainties in the cosmogenic neutrino flux are discussed and taken into
account in our analysis. The prospects for improving these bounds with the
Pierre Auger Observatory are also estimated. The unprecedented statistics to be
collected by this experiment in 6 yr of operation will probe the
neutrino-nucleon inelastic cross section at the level of Standard Model
predictions.Comment: To be published in JCA
Composition of UHECR and the Pierre Auger Observatory Spectrum
We fit the recently published Pierre Auger ultra-high energy cosmic ray
spectrum assuming that either nucleons or nuclei are emitted at the sources. We
consider the simplified cases of pure proton, or pure oxygen, or pure iron
injection. We perform an exhaustive scan in the source evolution factor, the
spectral index, the maximum energy of the source spectrum Z E_{max}, and the
minimum distance to the sources. We show that the Pierre Auger spectrum agrees
with any of the source compositions we assumed. For iron, in particular, there
are two distinct solutions with high and low E_{max} (e.g. 6.4 10^{20} eV and 2
10^{19} eV) respectively which could be distinguished by either a large
fraction or the near absence of proton primaries at the highest energies. We
raise the possibility that an iron dominated injected flux may be in line with
the latest composition measurement from the Pierre Auger Observatory where a
hint of heavy element dominance is seen.Comment: 19 pages, 6 figures (33 panels)- Uses iopart.cls and iopart12.clo- In
version 2: addition of a few sentences and two reference
Estimated Risk of HIV Acquisition and Practice for Preventing Occupational Exposure: A Study of Healthcare Workers at Tumbi and Dodoma Hospitals, Tanzania.
Health care workers (HCWs) are at risk of acquiring human immuno-deficiency virus (HIV) and other infections via exposure to infectious patients' blood and body fluids. The main objective of this study was to estimate the risk of HIV transmission and examine the practices for preventing occupational exposures among HCWs at Tumbi and Dodoma Hospitals in Tanzania. This study was carried out in two hospitals, namely, Tumbi in Coast Region and Dodoma in Dodoma Region. In each facility, hospital records of occupational exposure to HIV infection and its management were reviewed. In addition, practices to prevent occupational exposure to HIV infection among HCWs were observed. The estimated risk of HIV transmission due to needle stick injuries was calculated to be 7 cases per 1,000,000 HCWs-years. Over half of the observed hospital departments did not have guidelines for prevention and management of occupational exposure to HIV infections and lacked well displayed health and safety instructions. Approximately, one-fifth of the hospital departments visited failed to adhere to the instructions pertaining to correlation between waste materials and the corresponding colour coded bag/container/safety box. Seventy four percent of the hospital departments observed did not display instructions for handling infectious materials. Inappropriate use of gloves, lack of health and safety instructions, and lack of use of eye protective glasses were more frequently observed at Dodoma Hospital than at Tumbi Hospital. The poor quality of the hospital records at the two hospitals hampered our effort to characterise the risk of HIV infection acquisition by HCWs. Greater data completeness in hospital records is needed to allow the determination of the actual risk of HIV transmission for HCWs. To further reduce the risk of HIV infection due to occupational exposure, hospitals should be equipped with sufficient personal protective equipment (PPE) and HCWs should be reminded of the importance of adhering to universal precautions
GZK Photons Above 10 EeV
We calculate the flux of "GZK-photons", namely the flux of photons produced
by extragalactic nucleons through the resonant photoproduction of pions, the so
called GZK effect. This flux depends on the UHECR spectrum on Earth, of the
spectrum of nucleons emitted at the sources, which we characterize by its slope
and maximum energy, on the distribution of sources and on the intervening
cosmological backgrounds, in particular the magnetic field and radio
backgrounds. For the first time we calculate the GZK photons produced by
nuclei. We calculate the possible range of the GZK photon fraction of the total
UHECR flux for the AGASA and the HiRes spectra. We find that for nucleons
produced at the sources it could be as large as a few % and as low as 10^{-4}
above 10 EeV. For nuclei produced at the sources the maximum photon fraction is
a factor of 2 to 3 times smaller above 10 EeV but the minimum could be much
smaller than for nucleons. We also comment on cosmogenic neutrino fluxes.Comment: 20 pages, 9 figures (21 panels), iopart.cls and iopart12.clo needed
to typese
A commonly occurring genetic variant within the NPLOC4-TSPAN10-PDE6G gene cluster is associated with the risk of strabismus.
Strabismus refers to an abnormal alignment of the eyes leading to the loss of central binocular vision. Concomitant strabismus occurs when the angle of deviation is constant in all positions of gaze and often manifests in early childhood when it is considered to be a neurodevelopmental disorder of the visual system. As such, it is inherited as a complex genetic trait, affecting 2-4% of the population. A genome-wide association study (GWAS) for self-reported strabismus (1345 cases and 65,349 controls from UK Biobank) revealed a single genome-wide significant locus on chromosome 17q25. Approximately 20 variants across the NPLOC4-TSPAN10-PDE6G gene cluster and in almost perfect linkage disequilibrium (LD) were most strongly associated (lead variant: rs75078292, OR = 1.26, p = 2.24E-08). A recessive model provided a better fit to the data than an additive model. Association with strabismus was independent of refractive error, and the degree of association with strabismus was minimally attenuated after adjustment for amblyopia. The association with strabismus was replicated in an independent cohort of clinician-diagnosed children aged 7 years old (116 cases and 5084 controls; OR = 1.85, p = 0.009). The associated variants included 2 strong candidate causal variants predicted to have functional effects: rs6420484, which substitutes tyrosine for a conserved cysteine (C177Y) in the TSPAN10 gene, and a 4-bp deletion variant, rs397693108, predicted to cause a frameshift in TSPAN10. The population-attributable risk for the locus was approximately 8.4%, indicating an important role in conferring susceptibility to strabismus
Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289]
BACKGROUND: There is no generally accepted medical or surgical treatment to stop the progressive course of retinitis pigmentosa. Previous studies have suggested lutein as a potential treatment with positive effects on macular pigment density. The objective of this study was to examine the effect of lutein supplementation on preservation of visual function in patients with retinitis pigmentosa (RP) METHODS: In a double-masked randomized placebo-controlled phase I/II clinical trial with a cross-over design, 34 adult patients with RP were randomized to two groups. One group, consisted of 16 participants, received lutein supplementation (10 mg/d for 12 wks followed by 30 mg/d) for the first 24 weeks and then placebo for the following 24 weeks, while the other group included 18 participants for whom placebo (24 weeks) was administered prior to lutein. Visual acuity, contrast sensitivity, and central visual field were measured at different illumination levels at baseline and every week using a PC-based test at home. RESULTS: For visual acuity (VA) at normal illumination level, treatment with lutein reduced logMAR, i.e. improved VA, but this effect was not statistically significant. The changes in normal (100%), low (4%), and very low (0.1%) illumination log CS were not statistically significant (p-values: 0.34, 0.23, and 0.32, respectively). Lutein had a statistically significant effect on visual field (p-value: 0.038) and this effect increased in the model assuming a 6-week delay in effect of lutein. Comparing the development of vision measures against the natural loss expected to occur over the course of 48 weeks, most measures showed reduced decline, and these reductions were significant for normal illumination VA and CS. CONCLUSION: These results suggest that lutein supplementation improves visual field and also might improve visual acuity slightly, although these results should be interpreted cautiously. As a combined phase I and II clinical trial, this study demonstrated the efficacy and safety of lutein supplementation
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