14 research outputs found
Quality of investigations into unexpected deaths of infants and young children in England after implementation of national child death review procedures in 2008: a retrospective assessment
Objectives In 2008, new statutory national procedures for responding to unexpected child deaths were introduced throughout England. There has, to date, been no national audit of these procedures.
Study design Families bereaved by the unexpected death of a child under 4 years of age since 2008 were invited to participate. Factors contributing to the death and investigations after the death were explored. Telephone interviews were conducted, and coroners’ documents were obtained. The nature and quality of investigations was compared with the required procedures; information on each case was reviewed by a multiagency panel; and the death was categorised using the Avon clinicopathological classification.
Results Data were obtained from 91 bereaved families (64 infant deaths and 27 children aged 1–3 years); 85 remained unexplained after postmortem examination. Documentation of multiagency assessments was poorly recorded. Most (88%) families received a home visit from the police, but few (37%) received joint visits by police and healthcare professionals. Postmortem examinations closely followed national guidance; 94% involved paediatric pathologists; 61% of families had a final meeting with a paediatrician to explain the investigation outcome. There was no improvement in frequency of home visits by health professionals or final meetings with paediatricians between 2008–2013 and 2014–2017 and no improvement in parental satisfaction with the process.
Conclusions Statutory procedures need to be followed more closely. The implementation of a national child mortality database from 2019 will allow continuing audit of the quality of investigations after unexpected child deaths. An important area amenable to improvement is increased involvement by paediatricians
Why Doha Is Inescapable
The Free Trade Area of the Americas (FTAA) ran into rough weather in Miami
last November. The patchwork deal to let countries go in different directions on several
issues, as each FTAA member might fancy its interests to lie in, was little more than a
face-saving formula. But if one looks closely at the face, it is evident that USTR
Zoellick’s love affair with the strategy of going bilateral and regional, both as desirable in
itself (when many see these proliferating deals as a pox on the world trading system) and
as a strategic means to spur multilateralism (when in fact many regard it as harming it),
had floundered
Aspects of pulse oximetry screening for critical congenital heart defects: when, how and why?
Developmen
Prognosis and Resuscitation Status of Critically Ill Patients with Lung Cancer Admitted to the Intensive Care Unit
Grid Refinement Studies for an Ultra-Fast Fire in a One-Room Structure using the Fire Dynamics Simulator Code
Interferon Gamma Release Assays (IGRA) in tuberculosis diagnosis. New Guidelines of Centers for Disease Control and Prevention
The cost-effectiveness of progesterone in preventing miscarriages in women with early pregnancy bleeding: an economic evaluation based on the PRISM Trial
Objectives:
To assess the cost‐effectiveness of progesterone compared with placebo in preventing pregnancy loss in women with early pregnancy vaginal bleeding.
Design:
Economic evaluation alongside a large multi‐centre randomised placebo‐controlled trial.
Setting:
Forty‐eight UK NHS early pregnancy units.
Population:
Four thousand one hundred and fifty‐three women aged 16–39 years with bleeding in early pregnancy and ultrasound evidence of an intrauterine sac.
Methods:
An incremental cost‐effectiveness analysis was performed from National Health Service (NHS) and NHS and Personal Social Services perspectives. Subgroup analyses were carried out on women with one or more and three or more previous miscarriages.
Main outcome measures:
Cost per additional live birth at ≥34 weeks of gestation.
Results:
Progesterone intervention led to an effect difference of 0.022 (95% CI −0.004 to 0.050) in the trial. The mean cost per woman in the progesterone group was £76 (95% CI −£559 to £711) more than the mean cost in the placebo group. The incremental cost‐effectiveness ratio for progesterone compared with placebo was £3305 per additional live birth. For women with at least one previous miscarriage, progesterone was more effective than placebo with an effect difference of 0.055 (95% CI 0.014–0.096) and this was associated with a cost saving of £322 (95% CI −£1318 to £673).
Conclusions:
The results suggest that progesterone is associated with a small positive impact and a small additional cost. Both subgroup analyses were more favourable, especially for women who had one or more previous miscarriages. Given available evidence, progesterone is likely to be a cost‐effective intervention, particularly for women with previous miscarriage(s)