Multidecadal Signal of Solar Variability in the Upper Troposphere During the 20th Century

Studies based on data from the past 25-45 years show that irradiance changes related to the 11-yr solar cycle affect the circulation of the upper troposphere in the subtropics and midlatitudes. The signal has been interpreted as a northward displacement of the subtropical jet and the Ferrel cell with increasing solar irradiance. In model studies on the 11-yr solar signal this could be related to a weakening and at the same time broadening of the Hadley circulation initiated by stratospheric ozone anomalies. Other studies, focusing on the direct thermal effect at the Earth's surface on multidecadal scales, suggest a strengthening of the Hadley circulation induced by an increased equator-to-pole temperature gradient. In this paper we analyse the solar signal in the upper troposphere since 1922, using statistical reconstructions based on historical upper-air data. This allows us to address the multidecadal variability of solar irradiance, which was supposedly large in the first part of the 20th century. Using a simple regression model we find a consistent signal on the 11-yr time scale which fits well with studies based on later data. We also find a significant multidecadal signal that is similar to the 11-yr signal, but somewhat stronger. We interpret this signal as a poleward shift of the subtropical jet and the Ferrel cell. Comparing the magnitude of the two signals could provide important information on the feedback mechanisms involved in the solar climate relationship with respect to the Hadley and Ferrel circulations. However, in view of the uncertainty in the solar irradiance reconstructions, such interpretations are not currently possibl

SARS-CoV-2 vaccination in cardiothoracic organ transplant recipients: effective strategies wanted

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The combined immunohistochemical expression of AMBRA1 and SQSTM1 identifies patients with poorly differentiated cutaneous squamous cell carcinoma at risk of metastasis: A proof of concept study

\ua9 2024 AMLo Biosciences Ltd. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.Background: Cutaneous squamous cell carcinoma (cSCC) incidence continues to increase globally with, as of yet, an unmet need for reliable prognostic biomarkers to identify patients at increased risk of metastasis. The aim of the present study was to test the prognostic potential of the combined immunohistochemical expression of the autophagy regulatory biomarkers, AMBRA1 and SQSTM1, to identify high-risk patient subsets. Methods: A retrospective cohort of 68 formalin-fixed paraffin-embedded primary cSCCs with known 5-year metastatic outcomes were subjected to automated immunohistochemical staining for AMBRA1 and SQSTM1. Digital images of stained slides were annotated to define four regions of interest: the normal and peritumoral epidermis, the tumor mass, and the tumor growth front. H-score analysis was used to semi-quantify AMBRA1 or SQSTM1 expression in each region of interest using Aperio ImageScope software, with receiver operator characteristics and Kaplan–Meier analysis used to assess prognostic potential. Results: The combined loss of expression of AMBRA1 in the tumor growth front and SQSTM1 in the peritumoral epidermis identified patients with poorly differentiated cSCCs at risk of metastasis (*p < 0.05). Conclusions: Collectively, these proof of concept data suggest loss of the combined expression of AMBRA1 in the cSCC growth front and SQSTM1 in the peritumoral epidermis as a putative prognostic biomarker for poorly differentiated cSCC

SARS-CoV-2 vaccination in cardiothoracic organ transplant recipients: effective strategies wanted

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Effect of subsoiling on strength of a Chernozemic soil

Non-Peer Reviewe

Definitive chemoradiotherapy versus neoadjuvant chemoradiotherapy followed by radical surgery for locally advanced oesophageal squamous cell carcinoma:meta-analysis

Background: The literature lacks robust evidence comparing definitive chemoradiotherapy (dCRT) with neoadjuvant chemoradiotherapy and surgery (nCRS) for oesophageal squamous cell carcinoma (ESCC). This study aimed to compare long-term survival of these approaches in patients with ESCC.Methods: A systematic review performed according to PRISMA guidelines included studies identified from PubMed, Scopus, and Cochrane CENTRAL databases up to July 2021 comparing outcomes between dCRT and nCRS for ESCC. The main outcome measure was overall survival (OS), secondary outcome was disease-free survival (DFS). A meta-analysis was conducted using random-effects modelling to determine pooled adjusted multivariable hazard ratios (HRs).Results: Ten studies including 14 092 patients were included, of which 30 per cent received nCRS. Three studies were randomized clinical trials (RCTs) and the remainder were retrospective cohort studies. dCRT and nCRS regimens were reported in six studies and surgical quality control was reported in two studies. Outcomes for OS and DFS were reported in eight and three studies respectively. Following meta-analysis, nCRS demonstrated significantly longer OS (HR 0.68, 95 per cent c.i. 0.54 to 0.87, P < 0.001) and DFS (HR 0.50, 95 per cent c.i. 0.36 to 0.70, P < 0.001) compared with dCRT.Conclusion: Neoadjuvant chemoradiotherapy followed by oesophagectomy correlated with improved survival compared with definitive chemoradiation in the treatment of ESCC; however, there is a lack of literature on RCTs