Fracture Risk Assessment Tool (FRAX)®

For many years, there were no models for Polish population. Prospective studies showed that the use of British data model is reliable for the Polish patients, as supported by Przedlacki21,26,27 and others. Lately, a new version of the FRAX® method, including Polish data was introduced28,29. This triggered writing of the current paper, to continue farther studies of this population. Use of the described method to monitor treatment or to evaluate patients already treated, is pointless. Still, the method should be popularized, since only 10% of patients after an osteoporotic fracture are treated for the underlying condition3. The goal should be prevention of future fractures, return of independence in the activities of daily living and mobility

ZAP-70 and CD38 expression are independent prognostic factors in patients with B-cell chronic lymphocytic leukaemia and combined analysis improves their predictive value.

Recently identified biological risk factors in B-cell chronic lymphocytic leukemia (B-CLL) include ZAP-70 and CD38 expression. The present study was conducted to clarify whether a combined analysis could improve predictive impact of these two parameters. We examined the expression of ZAP-70 and CD38 by flow cytometry method in 217 newly diagnosed, consecutive, unselected and well characterized B-CLL patients in relation to laboratory parameters and clinical outcome. We confirmed that both ZAP-70 as well as CD38 were independent of prognostic factors. There was a significant correlation between the percentage of leukemic cells positive for ZAP-70 and the percentage of CD38+CD19+ cells (R=0.629; p=0.000001). Combined analysis of ZAP-70 and CD38 showed concordant results in 158/217 patients (72.8%), while in 59 patients the results were discordant (27.2%). A mean treatment free survival (TFS) was the longest in ZAP-70-CD38-patients (45.6 months, comparing to 13.6 months in ZAP-70+CD38+ group). Also a mean overall survival was the longest in ZAP-70-CD38- patients (224.7 months compared to 77.9 months in ZAP-70+CD38+ patients)

The use of neurorehabilitation techniques based on the currently used model of therapy in patients with neurological disorders

Adherence to the rehabilitation guidelines of the patient brings measurable favorable conditions to achieve the intended effect of returning the patient to health. The present model of rehabilitation of a neurological patient is recommended to be based on the use of rehabilitation methods that prescribe the use of a tool called ICF (International Classification of Functioning), with which we assess its disability and set up a rehabilitation plan. The ICF model assumes that it should follow a prescribed work schedule with the patient, which consists of 3 components: 1) structure 2) activity 3) participation. The whole medical team applies to the assumptions resulting from the above classification because of the improvement of the entire rehabilitation process. The role of the physiotherapist is to inform all nursing staff to make important decisions relevant to the role of the patient's vision, including the correct placement of the patient, which significantly prevents the development of pressure sores and contractures. Rehabilitation is designed to restore the patient's full fitness as quickly as possible and to allow him / her to stand up and, in the future, re-train his or her locomotive skills

Assessment of the pathway of apoptosis involving PAR-4, DAXX and ZIPK proteins in CLL patients and its relationship with the principal prognostic factors

Par-4 (prostate apoptosis response-4) protein was originally found upregulated in prostate tumor cells undergoing apoptosis. Then it was further identified as a proapoptotic protein upregulated both in normal and leukemic lymphocytes. The aim of our study was to assess PAR-4 protein expression in the B cells of CLL patients and to examine its relationship with the expression of other proteins involved in the apoptosis process, such as DAXX, ZIPK and BCL-2. We found a positive relationship between PAR-4 and BCL-2 protein expression. Additionally, there was a positive correlation between PAR-4 and both DAXX and ZIPK protein expression. The results of our research were also analyzed in association with the principal CLL prognostic factors. There was a positive correlation between the expression of PAR-4 protein and the lactate dehydrogenase (LDH) serum concentration (p < 0.005). The expression of PAR-4 protein in B cells correlated positively with the percentage of CD38+ cells (p < 0.05), as well as with CD38+/ZAP-70+ cells (p < 0.05). Moreover, we found a close relationship between LPL protein expression or LPL/ADAM29 MFI ratio and PAR-4 protein expression. Our results confirm the significance of apoptosis deregulation in CLL, and suggest a possible relationship between PAR-4 expression and the clinical course of the disease. This however requires further investigation. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 98&#8211;103

ZAP-70 and CD38 expression are independent prognostic factors in patients with B-cell chronic lymphocytic leukaemia and combined analysis improves their predictive value.

Recently identified biological risk factors in B-cell chronic lymphocytic leukemia (B-CLL) include ZAP-70 and CD38 expression. The present study was conducted to clarify whether a combined analysis could improve predictive impact of these two parameters. We examined the expression of ZAP-70 and CD38 by flow cytometry method in 217 newly diagnosed, consecutive, unselected and well characterized B-CLL patients in relation to laboratory parameters and clinical outcome. We confirmed that both ZAP-70 as well as CD38 were independent of prognostic factors. There was a significant correlation between the percentage of leukemic cells positive for ZAP-70 and the percentage of CD38+CD19+ cells (R=0.629; p=0.000001). Combined analysis of ZAP-70 and CD38 showed concordant results in 158/217 patients (72.8%), while in 59 patients the results were discordant (27.2%). A mean treatment free survival (TFS) was the longest in ZAP-70-CD38-patients (45.6 months, comparing to 13.6 months in ZAP-70+CD38+ group). Also a mean overall survival was the longest in ZAP-70-CD38- patients (224.7 months compared to 77.9 months in ZAP-70+CD38+ patients)

The beneficial effects of rehabilitation on hand function in patients with rheumatoid arthritis

Objectives: The hand is one of the main elements of the rehabilitation of patients with rheumatoid arthritis (RA) due to deformities, which occur in approximately 90% of patients. It is a serious problem, both in the psychological and functional aspect, connected with muscle strength reduction, a limited range of motion and non-acceptance of the changes in the shape of the limb. The study aimed to assess the effect of rehabilitation on the function of the hand in rheumatoid arthritis. Material and methods: The study group consisted of 40 women with RA. The patients had been previously treated at the Rehabilitation Department of the National Institute of Geriatrics, Rheumatology and Rehabilitation in Warsaw. The study group underwent 3 weeks of rehabilitation involving individual therapy, exercises with equipment, patient education and physical therapy. The control group included women without a diagnosis of RA, hands pain-free and fully mobile. In both groups the hand was assessed for grip value, grip quality and manipulative ability. In the study group the basis of pain intensity was noted. The measurements were performed twice – prior to the rehabilitation and after 3 weeks of rehabilitation in women with RA and once in women without hand problems. Results : The results obtained revealed marked limitation of hand function in patients with rheumatoid arthritis. The treatment resulted in an improvement of all assessed parameters except cylindrical grip, in which only a part of the findings was statistically significant. Conclusions : The analysis of the study material showed that appropriately adjusted and conducted hand physiotherapy in women with rheumatoid arthritis contributed to the improvement of its function by pain reduction, improved value and quality of grip, and also increased manipulative ability

Is Balance Training Using Biofeedback Effective in the Prophylaxis of Falls in Women over the Age of 65?

The paper aims to investigate the usefulness of training in improving mobility and reducing the risk of falls of patients with osteoarthritis by using a force plate and virtual reality as rehabilitation tools. The study involved 72 women randomly divided into two equal groups: the force plate training group, which underwent virtual balance training with visual motor feedback, and the gym training group, which received conventional balance training only. The functional balance assessment was performed before and after the rehabilitation by computerized posturography in a relaxed upright position with open and closed eyes, with visual motor feedback. In the FPT group in the feedback measurement, the mean radius of sways was 30% smaller after rehabilitation (p p < 0.001) and reached 92%, which is excellent for elderly people. Total stagnation and stumbling reported by patients decreased after rehabilitation compared to the first examination. Both tested forms of training can contribute to reducing the risk of falls. However, a more significant improvement was obtained in the force plate training group perhaps because the physical effort on a force plate trains the precise movements needed to reposition the centre of gravity without generating excessive inertia forces responsible for loss of balance and falls. Perhaps the most desirable method of intervention is to train a person’s ability to perform slow but definite body movements

The use of neurorehabilitation techniques based on the currently used model of therapy in patients with neurological disorders

Ogurkowski Karol, Sieklucka Ewa, Ogurkowska Angelika, Siminska Joanna, Porzych Piotr, Nowacka Krystyna, Hagner Wojciech. The use of neurorehabilitation techniques based on the currently used model of therapy in patients with neurological disorders. Journal of Education, Health and Sport. 2019;9(3):339-355. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2597916 http://ojs.ukw.edu.pl/index.php/johs/article/view/6706 https://pbn.nauka.gov.pl/sedno-webapp/works/908003 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eissn 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 18.02.2019. Revised: 18.02.2019. Accepted: 19.03.2019. The use of neurorehabilitation techniques based on the currently used model of therapy in patients with neurological disorders Karol Ogurkowski1, Ewa Sieklucka2, Angelika Ogurkowska3, Joanna Siminska1, Piotr Porzych1, Krystyna Nowacka1, Wojciech Hagner1 1Department and Clinic of Rehabilitation, Collegium Medicum im. L. Rydygiera in Bydgoszcz, University of Nicolaus Copernicus in Torun 2Trauma and Orthopedic Department, Specialized Municipal Hospital 3Department and Clinic of Geriatrics, Collegium Medicum im. L. Rydygiera in Bydgoszcz, University of Nicolaus Copernicus in Torun Summary Adherence to the rehabilitation guidelines of the patient brings measurable favorable conditions to achieve the intended effect of returning the patient to health. The present model of rehabilitation of a neurological patient is recommended to be based on the use of rehabilitation methods that prescribe the use of a tool called ICF (International Classification of Functioning), with which we assess its disability and set up a rehabilitation plan. The ICF model assumes that it should follow a prescribed work schedule with the patient, which consists of 3 components: 1) structure 2) activity 3) participation. The whole medical team applies to the assumptions resulting from the above classification because of the improvement of the entire rehabilitation process. The role of the physiotherapist is to inform all nursing staff to make important decisions relevant to the role of the patient's vision, including the correct placement of the patient, which significantly prevents the development of pressure sores and contractures. Rehabilitation is designed to restore the patient's full fitness as quickly as possible and to allow him / her to stand up and, in the future, re-train his or her locomotive skills. Key words: rehabilitation, ICF, neurorehabilitatio