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The Bolocam Galactic Plane Survey. XI. Temperatures and Substructure of Galactic Clumps Based on 350 ?M Observations
We present 107 maps of continuum emission at 350 mu m from Galactic molecular clumps. Observed sources were mainly selected from the Bolocam Galactic Plane Survey (BGPS) catalog, with three additional maps covering star-forming regions in the outer Galaxy. The higher resolution of the SHARC-II images (8."5 beam) compared with the 1.1 mm images from BGPS (33"beam) allowed us to identify a large population of smaller substructures within the clumps. A catalog is presented for the 1386 sources extracted from the 350 mu m maps. The color temperature distribution of clumps based on the two wavelengths has a median of 13.3 K and mean of 16.3 +/- 0.4 K, assuming an opacity law index of 1.7. For the structures with good determination of color temperatures, the mean ratio of gas temperature, determined from NH3 observations, to dust color temperature is 0.88 and the median ratio is 0.76. About half the clumps have more than 2 substructures and 22 clumps have more than 10. The fraction of the mass in dense substructures seen at 350 mu m compared to the mass of their parental clump is similar to 0.19, and the surface densities of these substructures are, on average, 2.2 times those seen in the clumps identified at 1.1 mm. For a well-characterized sample, 88 structures (31%) exceed a surface density of 0.2 g cm(-2), and 18 (6%) exceed 1.0 g cm(-2), thresholds for massive star Formation suggested by theorists.National Science Foundation through NSF grant AST-0708403NRAONSF AST-9980846, AST-0206158, AST-1109116Fulbright FellowshipASI, AgenziaSpaziale Italiana I/038/080/0, I/029/12/0national funding agency: CSA (Canada)national funding agency: NAOC (China)national funding agency: CEA (France)national funding agency: ASI (Italy)national funding agency: MCINN (Spain)national funding agency: Stockholm Observatory (Sweden)national funding agency: STFC (UK)national funding agency: NASA (USA)national funding agency: CNES (France)national funding agency: CNRS (France)Astronom
The Bolocam Galactic Plane Survey. XII. Distance Catalog Expansion Using Kinematic Isolation of Dense Molecular Cloud Structures With 13CO(1-0)
We present an expanded distance catalog for 1,710 molecular cloud structures
identified in the Bolocam Galactic Plane Survey (BGPS) version 2, representing
a nearly threefold increase over the previous BGPS distance catalog. We
additionally present a new method for incorporating extant data sets into our
Bayesian distance probability density function (DPDF) methodology. To augment
the dense-gas tracers (e.g., HCO+(3-2), NH3(1,1)) used to derive line-of-sight
velocities for kinematic distances, we utilize the Galactic Ring Survey
13CO(1-0) data to morphologically extract velocities for BGPS sources. The
outline of a BGPS source is used to select a region of the GRS 13CO data, along
with a reference region to subtract enveloping diffuse emission, to produce a
line profile of 13CO matched to the BGPS source. For objects with a HCO+(3-2)
velocity, \approx 95% of the new 13CO(1-0) velocities agree with that of the
dense gas. A new prior DPDF for kinematic distance ambiguity (KDA) resolution,
based on a validated formalism for associating molecular cloud structures with
known objects from the literature, is presented. We demonstrate this prior
using catalogs of masers with trigonometric parallaxes and HII regions with
robust KDA resolutions. The distance catalog presented here contains
well-constrained distance estimates for 20% of BGPS V2 sources, with typical
distance uncertainties \lesssim 0.5 kpc. Approximately 75% of the
well-constrained sources lie within 6 kpc of the Sun, concentrated in the
Scutum-Centarus arm. Galactocentric positions of objects additionally trace out
portions of the Sagittarius, Perseus, and Outer arms in the first and second
Galactic quadrants, and we also find evidence for significant regions of
interarm dense gas.Comment: 28 pages, 19 figures. Accepted for publication in ApJ.
Distance-Omnibus code available at https://github.com/BGPS/distance-omnibu
The Bolocam Galactic Plane Survey. XIII. Physical Properties and Mass Functions of Dense Molecular Cloud Structures
We use the distance probability density function (DPDF) formalism of
Ellsworth-Bowers et al. (2013, 2015) to derive physical properties for the
collection of 1,710 Bolocam Galactic Plane Survey (BGPS) version 2 sources with
well-constrained distance estimates. To account for Malmquist bias, we estimate
that the present sample of BGPS sources is 90% complete above 400 and
50% complete above 70 . The mass distributions for the entire sample
and astrophysically motivated subsets are generally fitted well by a lognormal
function, with approximately power-law distributions at high mass. Power-law
behavior emerges more clearly when the sample population is narrowed in
heliocentric distance (power-law index for sources nearer
than 6.5 kpc and for objects between 2 kpc and 10 kpc).
The high-mass power-law indices are generally for
various subsamples of sources, intermediate between that of giant molecular
clouds and the stellar initial mass function. The fit to the entire sample
yields a high-mass power-law . Physical
properties of BGPS sources are consistent with large molecular cloud clumps or
small molecular clouds, but the fractal nature of the dense interstellar medium
makes difficult the mapping of observational categories to the dominant
physical processes driving the observed structure. The face-on map of the
Galactic disk's mass surface density based on BGPS dense molecular cloud
structures reveals the high-mass star-forming regions W43, W49, and W51 as
prominent mass concentrations in the first quadrant. Furthermore, we present a
0.25-kpc resolution map of the dense gas mass fraction across the Galactic disk
that peaks around 5%.Comment: Accepted for publication in ApJ; 32 pages, 21 figure
The Bolocam Galactic Plane Survey IX: Data Release 2 and Outer Galaxy Extension
We present a re-reduction and expansion of the Bolocam Galactic Plane Survey,
first presented by Aguirre et al. (2011) and Rosolowsky et al. (2010). The BGPS
is a 1.1 mm survey of dust emission in the Northern galactic plane, covering
longitudes -10 < \ell < 90 and latitudes |b| < 0.5 with a typical 1-\sigma RMS
sensitivity of 30-100 mJy in a 33" beam. Version 2 of the survey includes an
additional 20 square degrees of coverage in the 3rd and 4th quadrants and 2
square degrees in the 1st quadrant. The new data release has improved angular
recovery, with complete recovery out to 80" and partial recovery to 300", and
reduced negative bowls around bright sources resulting from the atmospheric
subtraction process. We resolve the factor of 1.5 flux calibration offset
between the v1.0 data release and other data sets and determine that there is
no offset between v2.0 and other data sets. The v2.0 pointing accuracy is
tested against other surveys and demonstrated to be accurate and an improvement
over v1.0. We present simulations and tests of the pipeline and its properties,
including measurements of the pipeline's angular transfer function. The Bolocat
cataloging tool was used to extract a new catalog, which includes 8594 sources,
with 591 in the expanded regions. We have demonstrated that the Bolocat 40" and
80" apertures are accurate even in the presence of strong extended background
emission. The number of sources is lower than in v1.0, but the amount of flux
and area included in identified sources is larger.Comment: 36 pages, 16 figures, accepted to ApJS. Data available from
http://irsa.ipac.caltech.edu/data/BOLOCAM_GPS
The Bolocam Galactic Plane Survey. XIV. Physical Properties of Massive Starless and Star Forming Clumps
We sort molecular clouds between from the
Bolocam Galactic Plane Survey based on observational diagnostics of star
formation activity: compact sources, mid-IR color-selected
YSOs, and masers, and UCHII regions. We also
present a combined -derived gas kinetic temperature and maser catalog for clumps from our own GBT 100m observations and
from the literature. We identify a subsample of () starless
clump candidates, the largest and most robust sample identified from a blind
survey to date. Distributions of flux density, flux concentration, solid angle,
kinetic temperature, column density, radius, and mass show strong ( dex)
progressions when sorted by star formation indicator. The median starless clump
candidate is marginally sub-virial () with of clumps
with known distance being gravitationally bound (). These samples
show a statistically significant increase in the median clump mass of M from the starless candidates to clumps associated with
protostars. This trend could be due to (i) mass growth of the clumps at
Msun Myr for an average free-fall Myr
time-scale, (ii) a systematic factor of two increase in dust opacity from
starless to protostellar phases, (iii) and/or a variation in the ratio of
starless to protostellar clump lifetime that scales as . By
comparing to the observed number of maser containing clumps we
estimate the phase-lifetime of massive ( M) starless clumps to
be ; the majority
( M) have phase-lifetimes longer than their average free-fall
time.Comment: Accepted for publication in ApJ; 33 pages; 22 figures; 7 table
The Bolocam Galactic Plane Survey. VIII. A Mid-Infrared Kinematic Distance Discrimination Method
We present a new distance estimation method for dust-continuum-identified
molecular cloud clumps. Recent (sub-)millimeter Galactic plane surveys have
cataloged tens of thousands of these objects, but detailed study of their
physical properties requires robust distance determinations. We derive Bayesian
distance probability density functions (DPDFs) for 770 objects from the Bolocam
Galactic Plane Survey in the longitude range 7.5 < l < 65. The DPDF formalism
is based on kinematic distances, and uses external data sets to place prior
distance probabilities to resolve the kinematic distance ambiguity (KDA) for
objects in the inner Galaxy. We present priors related to the mid-infrared
absorption of dust in dense molecular regions and the Galactic distribution of
molecular gas. By assuming a numerical model of Galactic mid-infrared emission
and simple radiative transfer, we match the morphology of millimeter thermal
dust emission with mid-infrared absorption to compute a prior DPDF for distance
discrimination. Selecting objects first from (sub-)millimeter source catalogs
avoids a bias towards the darkest infrared dark clouds (IRDCs) and extends the
range of heliocentric distance and contrast range probed by mid-infrared
extinction. We derive well-constrained KDA resolutions for 618 molecular cloud
clumps, with approximately 15% placed at or beyond the tangent distance.
Objects sufficiently dark to be cataloged as IRDCs are generally placed at the
near kinematic distance. Distance comparisons with Galactic Ring Survey KDA
resolutions yield a 92% agreement, and a Galactic face-on view reveals sections
of the Sagittarius and Scutum-Centaurus Arms. This KDA-resolution method for
large catalogs of sources through the combination of (sub-)millimeter and
mid-infrared observations of molecular cloud clumps is generally applicable to
other dust-continuum Galactic plane surveys.Comment: Accepted for publication in ApJ; 29 pages, 16 figures. Data available
prior to publication by contacting the author
The Bolocam Galactic Plane Survey: Survey Description and Data Reduction
We present the Bolocam Galactic Plane Survey (BGPS), a 1.1 mm continuum
survey at 33" effective resolution of 170 square degrees of the Galactic Plane
visible from the northern hemisphere. The survey is contiguous over the range
-10.5 < l < 90.5, |b| < 0.5 and encompasses 133 square degrees, including some
extended regions |b| < 1.5. In addition to the contiguous region, four targeted
regions in the outer Galaxy were observed: IC1396, a region towards the Perseus
Arm, W3/4/5, and Gem OB1. The BGPS has detected approximately 8400 clumps over
the entire area to a limiting non-uniform 1-sigma noise level in the range 11
to 53 mJy/beam in the inner Galaxy. The BGPS source catalog is presented in a
companion paper (Rosolowsky et al. 2010). This paper details the survey
observations and data reduction methods for the images. We discuss in detail
the determination of astrometric and flux density calibration uncertainties and
compare our results to the literature. Data processing algorithms that separate
astronomical signals from time-variable atmospheric fluctuations in the data
time-stream are presented. These algorithms reproduce the structure of the
astronomical sky over a limited range of angular scales and produce artifacts
in the vicinity of bright sources. Based on simulations, we find that extended
emission on scales larger than about 5.9' is nearly completely attenuated (>
90%) and the linear scale at which the attenuation reaches 50% is 3.8'.
Comparison with other millimeter-wave data sets implies a possible systematic
offset in flux calibration, for which no cause has been discovered. This
presentation serves as a companion and guide to the public data release through
NASA's Infrared Processing and Analysis Center (IPAC) Infrared Science Archive
(IRSA). New data releases will be provided through IPAC IRSA with any future
improvements in the reduction.Comment: Accepted for publication in Astrophysical Journal Supplemen
Exebacase for Staphylococcus aureus bloodstream infection and endocarditis
BACKGROUND: Novel therapeutic approaches are critically needed for Staphylococcus aureus bloodstream infections (BSI), particularly for methicillin-resistant S. aureus (MRSA). Exebacase, a first-in-class antistaphylococcal lysin, is a direct lytic agent that is rapidly bacteriolytic, eradicates biofilms, and synergizes with antibiotics.
METHODS: In this superiority-design study, we randomly assigned 121 patients with S. aureus BSI/endocarditis to receive a single dose of exebacase or placebo. All patients received standard-of-care antibiotics. The primary efficacy endpoint was clinical outcome (responder rate) at Day 14.
RESULTS: Clinical responder rates at Day 14 were 70.4% and 60.0% in the exebacase + antibiotics and antibiotics alone groups, respectively (difference=10.4, 90% CI [-6.3, 27.2], p-value=0.31), and were 42.8 percentage points higher in the pre-specified exploratory MRSA subgroup (74.1% vs. 31.3%, difference=42.8, 90% CI [14.3, 71.4], ad hoc p value=0.01). Rates of adverse events (AEs) were similar in both groups. No AEs of hypersensitivity to exebacase were reported. Thirty-day all-cause mortality rates were 9.7% and 12.8% in the exebacase + antibiotics and antibiotics alone groups, respectively, with a notable difference in MRSA (3.7% vs. 25.0%, difference= -21.3, 90% CI [-45.1, 2.5], ad hoc p-value=0.06). Among MRSA patients in the United States, median length-of-stay was 4-days shorter and 30-day hospital readmission rates were 48 percentage points lower in the exebacase-treated group compared with antibiotics alone.
CONCLUSIONS: This study establishes proof-of-concept for exebacase and direct lytic agents as potential therapeutics and supports conduct of a confirmatory study focused on exebacase to treat MRSA BSI
The Bolocam Galactic Plane Survey: II. Catalog of The Image Data
We present a catalog of 8358 sources extracted from images produced by the Bolocam Galactic Plane Survey (BGPS). The BGPS is a survey of the millimeter dust continuum emission from the northern Galactic plane. The catalog sources are extracted using a custom algorithm, Bolocat, which was designed specifically to identify and characterize objects in the large-area maps generated from the Bolocam instrument. The catalog products are designed to facilitate follow-up observations of these relatively unstudied objects. The catalog is 98% complete from 0.4 Jy to 60 Jy over all object sizes for which the survey is sensitive ( \u3c 3\u27.5). We find that the sources extracted can best be described as molecular clumps-large dense regions in molecular clouds linked to cluster formation. We find that the flux density distribution of sources follows a power law with dN/dS alpha S(-2.4+/-0.1) and that the mean Galactic latitude for sources is significantly below the midplane: \u3c b \u3e = (-0 degrees.095 +/- 0 degrees.001)
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