Asynchronous Functional Reactive Programming for GUIs

Graphical user interfaces (GUIs) mediate many of our interactions with computers. Functional Reactive Programming (FRP) is a promising approach to GUI design, providing high-level, declarative, compositional abstractions to describe user interactions and time-dependent computations. We present Elm, a practical FRP language focused on easy creation of responsive GUIs. Elm has two major features: simple declarative support for Asynchronous FRP; and purely functional graphical layout. Asynchronous FRP allows the programmer to specify when the global ordering of event processing can be violated, and thus enables efficient concurrent execution of FRP programs; long-running computation can be executed asynchronously and not adversely affect the responsiveness of the user interface. Layout in Elm is achieved using a purely functional declarative framework that makes it simple to create and combine text, images, and video into rich multimedia displays. Together, Elm's two major features simplify the complicated task of creating responsive and usable GUIs.Engineering and Applied Science

Engaging residents to choose wisely: Resident Doctors of Canada resource stewardship recommendations

Background: Resident doctors are integral to healthcare delivery in Canada. Engaging residents in resource stewardship is important for professional development, but also as they are drivers of healthcare resource use. To date, no national resident-specific resource stewardship guideline has been developed. Resident Doctors of Canada (RDoC) in collaboration with Choosing Wisely Canada (CWC) sought to develop an evidence-informed, consensus-based list of five recommendations to promote resource stewardship.                  Methods: RDoC convened a taskforce with diverse geographic and specialty representation to develop candidate recommendations targeting resident resource stewardship behaviours using a consensus-based process, supported by a literature review. Residents across the country provided feedback on the candidate recommendations via an online questionnaire. The taskforce used this feedback to finalize the list.Results: The taskforce prepared 28 candidate recommendations for consideration. A detailed literature review and consensus process narrowed this list to 12 candidate recommendations for consultation. A total of 754 residents (754/10,068 residents = 7.5%) representing all provinces and levels of residency training reviewed and ranked the candidate recommendations. The highest-ranked recommendations comprised the final list.Conclusion: Resident doctors are willing and able to demonstrate leadership in advancing resource stewardship by the development of a national resident-specific list of Choosing Wisely Canada recommendations

The significance of R&D investment and ICT usage in generating high income economy: an analysis on selected ASEAN countries / Chong Fen Nee ... [et al.]

The main purpose of this study is to explore the impact of R&D investment on the proxies of income or wealth among ASEAN countries. Gross national income (GNI) per capital will be used as proxy of wealth in this study. This study is of significant because in order to cope with the globalization and transforming into knowledge based economy both the government and industries have beefed up efforts in R & D. Nevertheless, prior research only examined the significance of R&D investment at the firm rather than country level. Some believe that it enhances corporate growth while other found it generates higher income much later. In terms of methodology, multi-factor model will be employed as it is a better alternative comparing to the CAPM and APT in explaining variations in stock returns. Relevant data will be extracted from secondary resources. Furthermore, time series econometrics will be used to analyze and provide results to the objectives proposed in this study. Apart from providing additional information to the practitioners to facilitate better decision making in the future and enriching the existing literature to pave ways for more researchers to the academics, this study also intends to contribute useful input for future policy formulation

Effects of Hepatitis B Surface Antigen on Virus-specific and Global T Cells in Patients With Chronic HBV infection

10.1053/j.gastro.2020.04.019Gastroenterolog

Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey.

Primary Immune Regulatory Disorders (PIRD) are an expanding group of diseases caused by gene defects in several different immune pathways, such as regulatory T cell function. Patients with PIRD develop clinical manifestations associated with diminished and exaggerated immune responses. Management of these patients is complicated; oftentimes immunosuppressive therapies are insufficient, and patients may require hematopoietic cell transplant (HCT) for treatment. Analysis of HCT data in PIRD patients have previously focused on a single gene defect. This study surveyed transplanted patients with a phenotypic clinical picture consistent with PIRD treated in 33 Primary Immune Deficiency Treatment Consortium centers and European centers. Our data showed that PIRD patients often had immunodeficient and autoimmune features affecting multiple organ systems. Transplantation resulted in resolution of disease manifestations in more than half of the patients with an overall 5-years survival of 67%. This study, the first to encompass disorders across the PIRD spectrum, highlights the need for further research in PIRD management

Hydrophilic microporous membranes for selective ion separation and flow-battery energy storage

Membranes with fast and selective ion transport are widely used for water purification and devices for energy conversion and storage including fuel cells, redox flow batteries and electrochemical reactors. However, it remains challenging to design cost-effective, easily processed ion-conductive membranes with well-defined pore architectures. Here, we report a new approach to designing membranes with narrow molecular-sized channels and hydrophilic functionality that enable fast transport of salt ions and high size-exclusion selectivity towards small organic molecules. These membranes, based on polymers of intrinsic microporosity containing Tröger’s base or amidoxime groups, demonstrate that exquisite control over subnanometre pore structure, the introduction of hydrophilic functional groups and thickness control all play important roles in achieving fast ion transport combined with high molecular selectivity. These membranes enable aqueous organic flow batteries with high energy efficiency and high capacity retention, suggesting their utility for a variety of energy-related devices and water purification processes

Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors

Objectives The optimal management of locally advanced and metastatic pulmonary carcinoid tumors remains to be determined. Materials and methods A retrospective review was conducted on patients with typical and atypical pulmonary carcinoid tumors treated at our institutions between 1990 and 2012. Results 300 patients were identified with pulmonary carcinoid, (80 patients with atypical carcinoid), of whom 29 presented with metastatic disease (16 atypical). Of evaluable patients, 26 (41%) with stages I–III atypical carcinoid tumors recurred at a median time of 3.7 years (range, 0.4–32), compared to 3 (1%) patients with typical carcinoid (range, 8–12.3). 39 patients were treated with chemotherapy, including 30 patients with metastatic disease (27 atypical), and 7 patients were treated with adjuvant platinum–etoposide chemoradiation (6 atypical, 1 typical, 6 stage IIIA, 1 stage IIB). At a median follow-up of 2 years there were 2 recurrences in the 7 patients receiving adjuvant treatment. Median survival after diagnosis of metastatic disease for patients with atypical pulmonary carcinoid was 3.3 years with a 5-year survival of 24%. Treatment regimens showing efficacy in pulmonary carcinoid include 15 patients treated with octreotide-based therapies (10% response rate (RR), 70% disease control rate (DCR), 15 month median progression-free survival (PFS)), 13 patients treated with etoposide + platinum (23% RR, 69% DCR, 7 month median PFS), and 14 patients treated with temozolomide-based therapies (14% RR, 57% DCR, 10 month median PFS). 8 of 10 patients with octreotide-avid disease treated with an octreotide-based regimen experienced disease control (1 partial response, 7 stable disease) for a median of 18 months (range 6–72 months). Conclusions These results support our previous finding that a subset of pulmonary carcinoid tumors are responsive to chemotherapy