58 research outputs found
Molecular medicine and concepts of disease: the ethical value of a conceptual analysis of emerging biomedical technologies
Although it is now generally acknowledged that new biomedical technologies often produce new definitions and sometimes even new concepts of disease, this observation is rarely used in research that anticipates potential ethical issues in emerging technologies. This article argues that it is useful to start with an analysis of implied concepts of disease when anticipating ethical issues of biomedical technologies. It shows, moreover, that it is possible to do so at an early stage, i.e. when a technology is only just emerging. The specific case analysed here is that of āmolecular medicineā. This group of emerging technologies combines a ācascade modelā of disease processes with a āpersonal patternā model of bodily functioning. Whereas the ethical implications of the first are partly familiar from earlierāalbeit controversialāforms of preventive and predictive medicine, those of the second are quite novel and potentially far-reaching
Cord blood banking ā bio-objects on the borderlands between community and immunity
Umbilical cord blood (UCB) has become the focus of intense efforts to collect, screen and bank haematopoietic stem cells (HSCs) in hundreds of repositories around the world. UCB banking has developed through a broad spectrum of overlapping banking practices, sectors and institutional forms. Superficially at least, these sectors have been widely distinguished in bioethical and policy literature between notions of the āpublicā and the āprivateā, the commons and the market respectively. Our purpose in this paper is to reflect more critically on these distinctions and to articulate the complex practical and hybrid nature of cord blood as a ābio-objectā that straddles binary conceptions of the blood economies. The paper draws upon Roberto Espositoās reflections on biopolitics and his attempt to transcend the dualistic polarisations of immunity and community, or the private and the public. We suggest that his thoughts on immunitary hospitality resonate with many of the actual features and realpolitik of a necessarily internationalised and globally distributed UCB āimmunitary regimeā
Ethical issues in autologous stem cell transplantation (ASCT) in advanced breast cancer: A systematic literature review
BACKGROUND: An effectiveness assessment on ASCT in locally advanced and metastatic breast cancer identified serious ethical issues associated with this intervention. Our objective was to systematically review these aspects by means of a literature analysis. METHODS: We chose the reflexive Socratic approach as the review method using Hofmann's question list, conducted a comprehensive literature search in biomedical, psychological and ethics bibliographic databases and screened the resulting hits in a 2-step selection process. Relevant arguments were assembled from the included articles, and were assessed and assigned to the question list. Hofmann's questions were addressed by synthesizing these arguments. RESULTS: Of the identified 879 documents 102 included arguments related to one or more questions from Hofmann's question list. The most important ethical issues were the implementation of ASCT in clinical practice on the basis of phase-II trials in the 1990s and the publication of falsified data in the first randomized controlled trials (Bezwoda fraud), which caused significant negative effects on recruiting patients for further clinical trials and the doctor-patient relationship. Recent meta-analyses report a marginal effect in prolonging disease-free survival, accompanied by severe harms, including death. ASCT in breast cancer remains a stigmatized technology. Reported health-related-quality-of-life data are often at high risk of bias in favor of the survivors. Furthermore little attention has been paid to those patients who were dying. CONCLUSIONS: The questions were addressed in different degrees of completeness. All arguments were assignable to the questions. The central ethical dimensions of ASCT could be discussed by reviewing the published literature
Study on the patenting of inventions related to human stem cell research. [Table of Contents]
7 pages (out of 225 pages)Discusses the ethical issues of patenting stem cell technology
Study on the patenting of inventions related to human stem cell research. [Introduction]
2 pages (out of 225 pages)Discusses the ethical issues of patenting stem cell technology
Study on the patenting of inventions related to human stem cell research. [Part III]
42 pages (out of 225 pages)Discusses the ethical issues of patenting stem cell technology
Genetic Testing in the Workplace: The employees point of view
info:eu-repo/semantics/publishe
International Analysis of Institutional Review Boards Registered with the U.S. Office for Human Research Protections
Cultivating Humanity in Bio- and Artificial Sciences
The question asked in this book, Will Science Remain Human?, focuses on the fact that contemporary science is primarily performed through technological means. This unprecedented technological apparatus is not only reducing some human roles, but seems to have the potential for altering some fundamental structures of science itself. The supply of data from all knowledge domains as well as the availability of artificial forms of reasoning, judging, and deciding is radically transforming how science has been working lately, and even more how it will operate in the future. From this perspective āa renewed understanding of the human character of scienceā seems necessary as rationality tends to be constructed more and more as a sequence of machine readable codes and a series of ultrafast processes for elaborating information. Moreover, the risk exists for scientific knowledge to be ārepresented in a simplified way, hiding human responsibility, freedom, creativity and choice
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