Tres tumbas de la etapa Hispano-Goda en Gomacín, Puente la Reina (Navarra)

Se publican tres tumbas de una necrópolis inédita de la etapa visigoda (s. VIVIR d.C), descubierta en Puente la Reina, (Navarra, España). Se describe, junto a otras paleopatologías, el caso más antiguo de lepra identificado en España

Alteraciones volumétricas en las costillas: entre la tuberculosis y las enfermedades carenciales

X Congreso Nacional de Paleopatología. Univesidad Autónoma de Madrid, septiembre de 200

Tres tumbas de la etapa Hispano-Goda en Gomacín, Puente la Reina (Navarra)

Se publican tres tumbas de una necrópolis inédita de la etapa visigoda (s. VIVIR d.C), descubierta en Puente la Reina, (Navarra, España). Se describe, junto a otras paleopatologías, el caso más antiguo de lepra identificado en España

A novel KCNQ4 pore-region mutation (p.G296S) causes deafness by impairing cell-surface channel expression

Mutations in the potassium channel gene KCNQ4 underlie DFNA2, a subtype of autosomal dominant progressive, high-frequency hearing loss. Based on a phenotype-guided mutational screening we have identified a novel mutation c.886G>A, leading to the p.G296S substitution in the pore region of KCNQ4 channel. The possible impact of this mutation on total KCNQ4 protein expression, relative surface expression and channel function was investigated. When the G296S mutant was expressed in Xenopus oocytes, electrophysiological recordings did not show voltage-activated K+ currents. The p.G296S mutation impaired KCNQ4 channel activity in two manners. It greatly reduced surface expression and, secondarily, abolished channel function. The deficient expression at the cell surface membrane was further confirmed in non-permeabilized NIH-3T3 cells transfected with the mutant KCNQ4 tagged with the hemagglutinin epitope in the extracellular S1-S2 linker. Co-expression of mutant and wild type KCNQ4 in oocytes was performed to mimic the heterozygous condition of the p.G296S mutation in the patients. The results showed that the G296S mutant exerts a strong dominant-negative effect on potassium currents by reducing the wild type KCNQ4 channel expression at the cell surface. This is the first study to identify a trafficking-dependent dominant mechanism for the loss of KCNQ4 channel function in DFNA2. © Springer-Verlag 2007.Peer Reviewe

Making things public: Archaeologies of the Spanish Civil War

Public Archaeology 6(4), 2007, 203-226The archaeology of recent traumatic events, such as genocides, mass political killings and armed conflict, is inevitably controversial. This is also the case of the Spanish Civil War (1936-1939), where the incipient archaeology of the confrontation is marked by bitter debates: Should this conflicting past be remembered or forgotten? Which version of the past is it going to be remembered? What are the best politics of memory for a healthy democracy? The archaeologies of the war face manifold problems: the lack of interest in academia, which fosters amateurism; the great divide between public and scientific practice; the narrow perspectives of some undertakings; the lack of coordination among practitioners, and the threats to the material remains of the war. An integrated archaeology of the conflict, which helps to make things public, is defended here.Peer reviewe