Variability in practices for drinking water vaccination of meat chickens against infectious laryngotracheitis

Context: Drinking water vaccination of young meat chickens with Infectious Laryngotracheitis (ILT) vaccine is problematic. Vaccine failure and adverse vaccine reactions are frequently reported. Variations in the technique of applying ILT vaccines by this mass vaccination method need to be understood to contribute to improving the success of vaccination. Aims: This study aimed to examine variations in the techniques of application of Infectious Laryngotracheitis vaccines via drinking water for young meat chickens. Methods: Drinking water vaccination techniques were observed and recorded across 52 broiler flocks during ILT outbreaks in three geographic areas of Australia. Descriptive statistics for all variables were computed and variations between integrator company procedures were statistically compared. Key results: Despite rigorous standard operating procedures, wide variations were observed in time of water deprivation prior to vaccination (3–15 min), time drinking water was stabilised prior to addition of vaccine and the type of stabiliser product used, time to activate the flock following filling of the water lines with vaccine (10–127 min), time for the vaccine to be consumed (36–226 min) and the volume of drinking water per bird used to provide the vaccine (11–48 mL/bird). Conclusions: Variation in vaccination technique can affect the success of drinking water vaccination against ILT in young meat chickens. Implications: Understanding the importance of the variable factors in vaccine application method can improve the success of water vaccination against ILT

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Seasonality and regional disparity in attention to homelessness in UK newspapers between 2001 and 2020

This research examined the amount of media attention to homelessness in 11 UK newspapers with two main research questions: (1) Does the media coverage exhibit seasonal cyclical patterns in their attention to homelessness? (2) Do England's nine regions differ in the attention they receive after adjusting for their relative homelessness levels? Time series of all 4105 news reports with the keyword “homeless*” in their headline between 2001 and 2020 were tested for meteorological and monthly seasonal effects, revealing significantly greater attention in winter but decreased coverage in spring and summer. Contrary to expectation, further analysis suggested that the increased winter coverage was not related to the colder months but to the Christmas period. Regarding regional differences, London received the highest mentions in the news but after adjusting for the relative burden of homelessness, the North West emerged as receiving the most relative coverage. The East Midlands and East of England had the lowest adjusted attention scores. As suggested by the public arenas model, the findings of this research suggest that media focus on social problems like homelessness be culturally patterned with key events like Christmas shaping issue-prominence. Similarly, regional imbalances in attention may reflect a systemic bias in news reporting

PyAutoLens: Open-Source Strong Gravitational Lensing

Strong gravitational lensing, which can make a background source galaxy appears multiple times due to its light rays being deflected by the mass of one or more foreground lens galaxies, provides astronomers with a powerful tool to study dark matter, cosmology and the most distant Universe. PyAutoLens is an open-source Python 3.6+ package for strong gravitational lensing, with core features including fully automated strong lens modeling of galaxies and galaxy clusters, support for direct imaging and interferometer datasets and comprehensive tools for simulating samples of strong lenses. The API allows users to perform ray-tracing by using analytic light and mass profiles to build strong lens systems. Accompanying PyAutoLens is the autolens workspace, which includes example scripts, lens datasets and the HowToLens lectures in Jupyter notebook format which introduce non-experts to strong lensing using PyAutoLens. Readers can try PyAutoLens right now by going to the introduction Jupyter notebook on Binder or checkout the readthedocs for a complete overview of PyAutoLens’s features

Stakeholders’ perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study

Objectives The Bronchiolitis Endotracheal Surfactant Study (BESS) is a randomised controlled trial to determine the efficacy of endo-tracheal surfactant therapy for critically ill infants with bronchiolitis. To explore acceptability of BESS, including approach to consent within a limited time frame, we explored parent and staff experiences of trial involvement in the first two bronchiolitis seasons to inform subsequent trial conduct.Design A mixed-method embedded study involving a site staff survey, questionnaires and interviews with parents approached about BESS.Setting Fourteen UK paediatric intensive care units.Participants Of the 179 parents of children approached to take part in BESS, 75 parents (of 69 children) took part in the embedded study. Of these, 55/69 (78%) completed a questionnaire, and 15/69 (21%) were interviewed. Thirty-eight staff completed a questionnaire.Results Parents and staff found the trial acceptable. All constructs of the Adapted Theoretical Framework of Acceptability were met. Parents viewed surfactant as being low risk and hoped their child’s participation would help others in the future. Although parents supported research without prior consent in studies of time critical interventions, they believed there was sufficient time to consider this trial. Parents recommended that prospective informed consent should continue to be sought for BESS. Many felt that the time between the consent process and intervention being administered took too long and should be ‘streamlined’ to avoid delays in administration of trial interventions. Staff described how the training and trial processes worked well, yet patients were missed due to lack of staff to deliver the intervention, particularly at weekends.Conclusion Parents and staff supported BESS trial and highlighted aspects of the protocol, which should be refined, including a streamlined informed consent process. Findings will be useful to inform proportionate approaches to consent in future paediatric trials where there is a short timeframe for consent discussions.Trial registration number ISRCTN11746266