814 research outputs found
From Design to Production Control Through the Integration of Engineering Data Management and Workflow Management Systems
At a time when many companies are under pressure to reduce "times-to-market"
the management of product information from the early stages of design through
assembly to manufacture and production has become increasingly important.
Similarly in the construction of high energy physics devices the collection of
(often evolving) engineering data is central to the subsequent physics
analysis. Traditionally in industry design engineers have employed Engineering
Data Management Systems (also called Product Data Management Systems) to
coordinate and control access to documented versions of product designs.
However, these systems provide control only at the collaborative design level
and are seldom used beyond design. Workflow management systems, on the other
hand, are employed in industry to coordinate and support the more complex and
repeatable work processes of the production environment. Commercial workflow
products cannot support the highly dynamic activities found both in the design
stages of product development and in rapidly evolving workflow definitions. The
integration of Product Data Management with Workflow Management can provide
support for product development from initial CAD/CAM collaborative design
through to the support and optimisation of production workflow activities. This
paper investigates this integration and proposes a philosophy for the support
of product data throughout the full development and production lifecycle and
demonstrates its usefulness in the construction of CMS detectors.Comment: 18 pages, 13 figure
Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1.
One third of inherited genetic diseases are caused by mRNAs harboring premature termination codons as a result of nonsense mutations. These aberrant mRNAs are degraded by the Nonsense-Mediated mRNA Decay (NMD) pathway. A central component of the NMD pathway is Upf1, an RNA-dependent ATPase and helicase. Upf1 is a known phosphorylated protein, but only portions of this large protein have been examined for phosphorylation sites and the functional relevance of its phosphorylation has not been elucidated in Saccharomyces cerevisiae. Using tandem mass spectrometry analyses, we report the identification of 11 putative phosphorylated sites in S. cerevisiae Upf1. Five of these phosphorylated residues are located within the ATPase and helicase domains and are conserved in higher eukaryotes, suggesting a biological significance for their phosphorylation. Indeed, functional analysis demonstrated that a small carboxy-terminal motif harboring at least three phosphorylated amino acids is important for three Upf1 functions: ATPase activity, NMD activity and the ability to promote translation termination efficiency. We provide evidence that two tyrosines within this phospho-motif (Y-738 and Y-742) act redundantly to promote ATP hydrolysis, NMD efficiency and translation termination fidelity
A procedure for the change point problem in parametric models based on phi-divergence test-statistics
This paper studies the change point problem for a general parametric,
univariate or multivariate family of distributions. An information theoretic
procedure is developed which is based on general divergence measures for
testing the hypothesis of the existence of a change. For comparing the accuracy
of the new test-statistic a simulation study is performed for the special case
of a univariate discrete model. Finally, the procedure proposed in this paper
is illustrated through a classical change-point example
Non Fermi Liquid behavior in the under-screened Kondo model
Using the Schwinger boson spin representation, we reveal a new aspect to the
physics of a partially screened magnetic moment in a metal, as described by the
spin Kondo model. We show that the residual ferromagnetic interaction
between a partially screened spin and the electron sea destabilizes the Landau
Fermi liquid, forming a singular Fermi liquid with a divergence in the low temperature specific heat coefficient
. A magnetic field tunes this system back into Landau Fermi liquid
with a Fermi temperature proportional to . We discuss a
possible link with field-tuned quantum criticality in heavy electron materials.Comment: References corrected. Minor changes to tex
Estudo comparativo entre a técnica da obstrução do fluxo arterial e a técnica de estimulador de nervos periféricos em cães submetidos ao bloqueio de plexo braquial
O artigo não apresenta resumo
Avaliação pré-anestésica dos valores de hematócrito e hemoglobina em cães com fraturas de ossos longos
O artigo não apresenta resumo
Detector Construction Management and Quality Control: Establishing and Using a CRISTAL System
The CRISTAL (Cooperating Repositories and an Information System for Tracking
Assembly Lifecycles) project is delivering a software system to facilitate the
management of the engineering data collected at each stage of production of
CMS. CRISTAL captures all the physical characteristics of CMS components as
each sub-detector is tested and assembled. These data are retained for later
use in areas such as detector slow control, calibration and maintenance.
CRISTAL must, therefore, support different views onto its data dependent on the
role of the user. These data viewpoints are investigated in this paper. In the
recent past two CMS Notes have been written about CRISTAL. The first note, CMS
1996/003, detailed the requirements for CRISTAL, its relationship to other CMS
software, its objectives and reviewed the technology on which it would be
based. CMS 1997/104 explained some important design concepts on which CRISTAL
is and showed how CRISTAL integrated the domains of product data man- agement
and workflow management. This note explains, through the use of diagrams, how
CRISTAL can be established for detector production and used as the information
source for analyses, such as calibration and slow controls, carried out by
physicists. The reader should consult the earlier CMS Notes and conference
papers for technical detail on CRISTAL - this note concentrates on issues
surrounding the practical use of the CRISTAL software.Comment: 16 pages, 14 figure
Planar projections of graphs
We introduce and study a new graph representation where vertices are embedded
in three or more dimensions, and in which the edges are drawn on the
projections onto the axis-parallel planes. We show that the complete graph on
vertices has a representation in planes. In 3
dimensions, we show that there exist graphs with edges that can be
projected onto two orthogonal planes, and that this is best possible. Finally,
we obtain bounds in terms of parameters such as geometric thickness and linear
arboricity. Using such a bound, we show that every graph of maximum degree 5
has a plane-projectable representation in 3 dimensions.Comment: Accepted at CALDAM 202
Susceptibility of Aedes albopictus and Culex quinquefasciatus to Japanese encephalitis virus; 35710580
Background: Japanese encephalitis virus (JEV) is the principal cause of mosquito-borne encephalitis in human populations within Asia. If introduced into new geographic areas, it could have further implications for public and animal health. However, potential mosquito vectors for virus transmission have not been fully investigated. The Asian tiger mosquito, Aedes albopictus, has emerged in Europe and is now expanding its geographical range into more northerly latitudes. Culex quinquefasciatus, although absent from Europe, has been detected in Turkey, a country with territory in Europe, and could act as a vector for JEV in other regions. To assess the risk of these invasive species acting as vectors for JEV and therefore potentially contributing to its geographical expansion, we have investigated the vector competence of Ae. albopictus and Cx. quinquefasciatus. Methods: Two colonised lines of Ae. albopictus (Italy and Spain) and a line of Cx. quinquefasciatus (Tanzania) were compared for susceptibility to infection by oral feeding with JEV strain SA-14, genotype III at 106 PFU/ml and maintained at 25 °C. Specimens were processed at 7 and 14 days post-inoculation (dpi). Rates of infection, dissemination and transmission were assessed through detection of viral RNA by real-time polymerase chain reaction (RT-PCR) in mosquito body, legs and saliva, respectively, at each time point. Where possible, infection and dissemination were confirmed by immunohistochemical (IHC) detection of the JEV envelope protein. Results: Aedes albopictus from Italy showed no susceptibility to infection with JEV strain SA-14. Conversely, Ae. albopictus colonised in Spain was susceptible and 100% of infected mosquitoes that were subjected to saliva screening expressed viral RNA at 14 dpi. Culex quinquefasciatus was highly susceptible to infection as early as 7 dpi and 50% of infected mosquitoes that were subjected to saliva screening expressed viral RNA at 14 dpi. Infection and dissemination were confirmed in Cx. quinquefasciatus by IHC detection of JEV envelope protein in both the mid-gut and salivary glands. Conclusions: Aedes albopictus from two different locations in Europe range from being susceptible to JEV and capable of transmission through to being resistant. Culex quinquefasciatus also appears highly susceptible; therefore, both species could potentially act as vectors for JEV and facilitate the emergence of JEV into new regions. Graphical Abstract: Figure not available: see fulltext.] © 2022, The Author(s)
Multiscale modelling of vascular tumour growth in 3D: the roles of domain size & boundary condition
We investigate a three-dimensional multiscale model of vascular tumour growth, which couples blood flow, angiogenesis, vascular remodelling, nutrient/growth factor transport, movement of, and interactions between, normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. In particular, we determine how the domain size, aspect ratio and initial vascular network influence the tumour's growth dynamics and its long-time composition. We establish whether it is possible to extrapolate simulation results obtained for small domains to larger ones, by constructing a large simulation domain from a number of identical subdomains, each subsystem initially comprising two parallel parent vessels, with associated cells and diffusible substances. We find that the subsystem is not representative of the full domain and conclude that, for this initial vessel geometry, interactions between adjacent subsystems contribute to the overall growth dynamics. We then show that extrapolation of results from a small subdomain to a larger domain can only be made if the subdomain is sufficiently large and is initialised with a sufficiently complex vascular network. Motivated by these results, we perform simulations to investigate the tumour's response to therapy and show that the probability of tumour elimination in a larger domain can be extrapolated from simulation results on a smaller domain. Finally, we demonstrate how our model may be combined with experimental data, to predict the spatio-temporal evolution of a vascular tumour
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