Nuevo género de avispa agallícola del encino, Kokkocynips Pujade-Villar & Melika, gen. n., con descripción de una nueva especies de México (Hymenoptera, Cynipidae)

A new genus of oak gallwasp, Kokkocynips Pujade-Villar & Melika gen.n., is described from Mexico. Diagnostic characters and generic limits of the new genus are discussed in detail. Galls were found on branches of Quercus acutifolia Née. Diagnostic characters, distribution and biology of the new species are described and illustrated.Se describe un nuevo género de cinípido agallícola, Kokkocynips Pujade-Villar & Melika n. gen. (Hymenoptera: Cynipidae: Cynipini) de México. Se discuten en detalle los caracteres diagnósticos y los límites genéricos de este nuevo género. Las agallas se encuentran en las ramas de Quercus acutifolia Née. Se describen e ilustran los caracteres diagnósticos, su distribución y la biología de la nueva especie

Amplified Genes May Be Overexpressed, Unchanged, or Downregulated in Cervical Cancer Cell Lines

Several copy number-altered regions (CNAs) have been identified in the genome of cervical cancer, notably, amplifications of 3q and 5p. However, the contribution of copy-number alterations to cervical carcinogenesis is unresolved because genome-wide there exists a lack of correlation between copy-number alterations and gene expression. In this study, we investigated whether CNAs in the cell lines CaLo, CaSki, HeLa, and SiHa were associated with changes in gene expression. On average, 19.2% of the cell-line genomes had CNAs. However, only 2.4% comprised minimal recurrent regions (MRRs) common to all the cell lines. Whereas 3q had limited common gains (13%), 5p was entirely duplicated recurrently. Genome-wide, only 15.6% of genes located in CNAs changed gene expression; in contrast, the rate in MRRs was up to 3 times this. Chr 5p was confirmed entirely amplified by FISH; however, maximum 33.5% of the explored genes in 5p were deregulated. In 3q, this rate was 13.4%. Even in 3q26, which had 5 MRRs and 38.7% recurrently gained SNPs, the rate was only 15.1%. Interestingly, up to 19% of deregulated genes in 5p and 73% in 3q26 were downregulated, suggesting additional factors were involved in gene repression. The deregulated genes in 3q and 5p occurred in clusters, suggesting local chromatin factors may also influence gene expression. In regions amplified discontinuously, downregulated genes increased steadily as the number of amplified SNPs increased (p<0.01, Spearman's correlation). Therefore, partial gene amplification may function in silencing gene expression. Additional genes in 1q, 3q and 5p could be involved in cervical carcinogenesis, specifically in apoptosis. These include PARP1 in 1q, TNFSF10 and ECT2 in 3q and CLPTM1L, AHRR, PDCD6, and DAP in 5p. Overall, gene expression and copy-number profiles reveal factors other than gene dosage, like epigenetic or chromatin domains, may influence gene expression within the entirely amplified genome segments

Una especie nueva de avispa gallícola para México: Andricus sphaericus Pujade-Villar n. sp. (Hymenoptera: Cynipidae: Cynipini)

Se describe una nueva especie de cinípido gallícola de México, Andricus sphaericus Pujade-Villar n. sp., solo conocida por su forma sexual. Induce agallas en las hojas de Quercus rugosa Née. Representa la segunda colecta de una generación sexual del género Andricus para México. Se proporcionan datos referidos a la diagnosis, distribución y biología de esta nueva especie

High Energy Physics Opportunities Using Reactor Antineutrinos

Nuclear reactors are uniquely powerful, abundant, and flavor-pure sources of antineutrinos that continue to play a vital role in the US neutrino physics program. The US reactor antineutrino physics community is a diverse interest group encompassing many detection technologies and many particle physics topics, including Standard Model and short-baseline oscillations, BSM physics searches, and reactor flux and spectrum modeling. The community's aims offer strong complimentary with numerous aspects of the wider US neutrino program and have direct relevance to most of the topical sub-groups composing the Snowmass 2021 Neutrino Frontier. Reactor neutrino experiments also have a direct societal impact and have become a strong workforce and technology development pipeline for DOE National Laboratories and universities. This white paper, prepared as a submission to the Snowmass 2021 community organizing exercise, will survey the state of the reactor antineutrino physics field and summarize the ways in which current and future reactor antineutrino experiments can play a critical role in advancing the field of particle physics in the next decade