Scalable numerical approach for the steady-state ab initio laser theory

We present an efficient and flexible method for solving the non-linear lasing equations of the steady-state ab initio laser theory. Our strategy is to solve the underlying system of partial differential equations directly, without the need of setting up a parametrized basis of constant flux states. We validate this approach in one-dimensional as well as in cylindrical systems, and demonstrate its scalability to full-vector three-dimensional calculations in photonic-crystal slabs. Our method paves the way for efficient and accurate simulations of lasing structures which were previously inaccessible.Comment: 17 pages, 8 figure

To respond or not to respond - a personal perspective of intestinal tolerance

For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena. However, this has changed dramatically in recent years with the realization of how important the microbiota is in shaping immune function throughout the body, and almost every major immunology institution now includes the intestine as an area of interest. One of the most important aspects of the intestinal immune system is how it discriminates carefully between harmless and harmful antigens, in particular, its ability to generate active tolerance to materials such as commensal bacteria and food proteins. This phenomenon has been recognized for more than 100 years, and it is essential for preventing inflammatory disease in the intestine, but its basis remains enigmatic. Here, I discuss the progress that has been made in understanding oral tolerance during my 40 years in the field and highlight the topics that will be the focus of future research

The Conundrum of Low Achievement and Feedback for Learning

The literature on improving student engagement with assessment and feedback has a tendency to treat all students as if they are the same. Students with lower levels of attainment are generally underrepresented within empirical studies and their feedback behaviours are less well understood. The recent drive to improve student assessment and feedback literacy and the move from ‘feedback’ being information about a task to being a process of understanding and using performance information is a larger conceptual leap for some students than others. In this paper, we consider issues surrounding the transition to new modes of feedback, focusing on what is needed for those who find study difficult and persistently are disappointed by their levels of attainment, to benefit from and take advantage of our feedback pedagogies. We examine literature advocating strategies such as increasing agency, using praise, developing feedback literacy and cultivating a growth mind-set. We argue that students who underachieve may benefit from strong relationships with educators and peers; exposure to feedback rich, low stakes environments, which permit repeated integrations of practice and feedback and building feedback literacy through peer assessment activities

The pancreatic beta cell surface proteome

The pancreatic beta cell is responsible for maintaining normoglycaemia by secreting an appropriate amount of insulin according to blood glucose levels. The accurate sensing of the beta cell extracellular environment is therefore crucial to this endocrine function and is transmitted via its cell surface proteome. Various surface proteins that mediate or affect beta cell endocrine function have been identified, including growth factor and cytokine receptors, transporters, ion channels and proteases, attributing important roles to surface proteins in the adaptive behaviour of beta cells in response to acute and chronic environmental changes. However, the largely unknown composition of the beta cell surface proteome is likely to harbour yet more information about these mechanisms and provide novel points of therapeutic intervention and diagnostic tools. This article will provide an overview of the functional complexity of the beta cell surface proteome and selected surface proteins, outline the mechanisms by which their activity may be modulated, discuss the methods and challenges of comprehensively mapping and studying the beta cell surface proteome, and address the potential of this interesting subproteome for diagnostic and therapeutic applications in human disease

Seismic resonances of spherical acoustic cavities

We study the interaction of a seismic wavefield with a spherical acoustic gas- or fluid-filled cavity. The intention of this study is to clarify whether seismic resonances can be expected, a characteristic feature that may help in detecting cavities in the subsurface. This is important for many applications, in particular the detection of underground nuclear explosions, which are to be prohibited by the Comprehensive Test Ban Treaty. To calculate the full seismic wavefield from an incident plane wave that interacts with the cavity, we considered an analytic formulation of the problem. The wavefield interaction consists of elastic scattering and the wavefield interaction between the acoustic and elastic media. Acoustic resonant modes caused by internal reflections in the acoustic cavity show up as spectral peaks in the frequency domain. The resonant peaks coincide with the eigenfrequencies of the un-damped system described by the particular acoustic medium bounded in a sphere with stiff walls. The filling of the cavity could thus be determined by the observation of spectral peaks from acoustic resonances. By energy transmission from the internal oscillations back into the elastic domain, the oscillations experience damping, resulting in a frequency shift and a limitation of the resonance amplitudes. In case of a gas-filled cavity, the impedance contrast is still high, which means low damping of the internal oscillations resulting in very narrow resonances of high amplitude. In synthetic seismograms calculated in the surrounding elastic domain, the acoustic resonances of gas-filled cavities show up as persisting oscillations. However, due to the weak acoustic–elastic coupling in this case, the amplitudes of the oscillations are very low. Due to a lower impedance contrast, a fluid-filled cavity has a stronger acoustic–elastic coupling, which results in wide spectral peaks of lower amplitudes. In the synthetic seismograms derived in the surrounding medium of fluid-filled cavities, acoustic resonances show up as strong but fast decaying reverberations