The pedagogical character of the biographical narratives in the context of approach to student-centered learning

A melhoria da formação inicial de professores, nas últimas décadas, está sendo investida de novos desafios, especialmente, tendo em conta a emergência das denominadas sociedades do conhecimento.Nas reformas para o Ensino Superior, especialmente no âmbito da constituição do Espaço Europeu do Ensino Superior, a abordagem da aprendizagem centrada nos estudantes é fulcral. Este artigo, do tipo metanalítico, tem por objetivo argumentar em favor douso das narrativas biográficas, segundo diversas perspetivas, e, especialmente, nas que centram-se na ideia da “voz do estudante” como estratégia de efetivação da abordagem de ensino centrada nos estudantes. Objetiva, ainda, discutir alguns dos desafios inerentes à implementação desta abordagem no contexto da formação inicial de professores e, a partir dessa discussão, apresentar uma perspetiva de formação que pode dar pistas de superação dos referidos desafiosLa mejoría de la formación inicial de profesores, en las últimas décadas, está siendo investida de nuevos desafíos, especialmente teniendo en cuenta la emergencia de las denominadas sociedades del conocimiento. En ese contexto emergen reformas para la Enseñanza Superior donde el abordaje del aprendizaje centrado en los estudiantes y el aprendizaje a lo largo de la vida son céntricos. Este artículo, del tipo metanalítico, tiene por objetivo argumentar en favor del uso de las narrativas biográficas, según diversas perspectivas, y especialmente, en las que se centran en la idea de la “voz del estudiante” como estrategia efectiva del abordaje de la enseñanza centrada en los estudiantes. Se centrará en la discusión de algunos de los desafíos inherentes a la implementación de este abordaje en el contexto de la formación inicial de profesores y, a partir de esa discusión, presentar una perspectiva de formación que puede dar pistas de superación de los referidos desafíosImproving teacher education in recent decades is being invested in new challenges, especially given the emergence of so-called knowledge societies. In this context emerge reforms for Higher Education where the approach to student-centered learning and lifelong learning are central. This kind of metaanalytic article aims to argue the use of biographical narratives, according to different perspectives, and especially those that focus on the idea of “student voice” as a strategy to develop the teaching approach centered, on students. Also, aims to discuss some of the challenges inherent in implementing this approach in the context of initial teacher education, and from that, bring out a perspective of training that could give clues for overcoming these challenge

Paving the way to overcome antifungal drug resistance: current practices and novel developments for rapid and reliable antifungal susceptibility testing

The past year has established the link between the COVID-19 pandemic and the global spread of severe fungal infections; thus, underscoring the critical need for rapid and realizable fungal disease diagnostics. While in recent years, health authorities, such as the Centers for Disease Control and Prevention, have reported the alarming emergence and spread of drug-resistant pathogenic fungi and warned against the devastating consequences, progress in the diagnosis and treatment of fungal infections is limited. Early diagnosis and patient-tailored therapy are established to be key in reducing morbidity and mortality associated with fungal (and cofungal) infections. As such, antifungal susceptibility testing (AFST) is crucial in revealing susceptibility or resistance of these pathogens and initiating correct antifungal therapy. Today, gold standard AFST methods require several days for completion, and thus this much delayed time for answer limits their clinical application. This review focuses on the advancements made in developing novel AFST techniques and discusses their implications in the context of the practiced clinical workflow. The aim of this work is to highlight the advantages and drawbacks of currently available methods and identify the main gaps hindering their progress toward clinical application

A4_3 All Aboard the RLS Legacy - Sailing the Stars!

In this paper we reviewed the feasibility of using a galleon-style ship in space, replacing the canvas sails with solar sails as seen in Walt Disney Studios’ Treasure Planet. We considered the solar radiation force on the solar sails, and incorporated gravitational influences and spectral classifications of the host star. We found that the gravitational force always dominates, and the ship would spiral into the star. Furthermore, we discuss the ship riding a supernova shock wave, subjected to a net force of 6.34 × 10^7 N, yet the crew and ship still come to a fiery end

A4_1 Gigavolt Flop

With the popularity of Pokémon peaking, we carried out an investigation into the energy of Pikachu's new 'Gigavolt Havoc' attack, and its thermal effect on the ice-shelled Pokémon Sandshrew. With the assumption of a parallel plate capacitor layout, we found the energy of this attack (when fully converted to thermal energy) would melt 16 % ± 5 % (at 273 K) of Sandshrew's shell

Characterization of a supercoil-dependent S1 sensitive site 5\u27 to the Drosophila melanogaster hsp 26 gene

We have analyzed the prominent supercoil-dependent S1 nuclease cleavage site 5\u27 to hsp 26 in the plasmid 88B13, which contains 11.7 kilobases from the Drosophila locus 67B1. The double stranded cleavage product is generated by initial nicking on the purine strand, six preferred sites occurring between positions -96 and -90 (relative to the start of transcription) with weaker ones extending to position -84, followed by cleavage on the pyrimidine strand at positions -86 and -84. A derivative of 88B13, 88B13-X, was generated by insertion of an Xho I linker at position -84; this does not affect the positions or strand specificity of the S1 cleavage in that region. A small deletion, delta 41.1, removes the homopurine/homopyrimidine stretch from positions -86 to -132 and is no longer sensitive to cleavage by S1 nuclease 5\u27 to hsp 26. Mung bean and P1 nucleases recognize the same site 5\u27 to hsp 26 and give the same general pattern of cleavage. All three nucleases show an initial cleavage of 88B13 DNA at this site at pH 5.5 but not at pH 6.5, indicating that the DNA structure there may be pH dependent in vitro

Datenbankenunterstützung für das Protein-Protein-Docking: ein effizienter und robuster Feature-Index

In der vorliegenden Arbeit schlagen wir eine Architektur für ein Dockingsystem vor, das zu einem gegebenen Anfrageprotein alle möglichen Dockingpartner und deren zugehörige Konstellationen in einer Proteindatenbank sucht. Die einzelnen Filter- und Bewertungsschritte dieses Dockingsystems sollen durch den Einsatz räumlicher Zugriffsstrukturen unterstützt werden. Hier behandeln wir insbesondere die Verwendung eines effizienten und robusten Feature-Index. Dieser dient dazu, aus dem Raum aller möglichen Konstellationen von Partnerproteinen aus der Datenbank gute Kandidatenvorschläge zu ermitteln. Dazu werden im Vorfeld die Proteinoberflächen regionalisiert, in einem k-dimensionalen Raum von Kennzahlen beschrieben und in einer k-dimensionalen räumlichen Indexstruktur verwaltet. Für die Docking-Suche wird das Anfrageprotein analog regionalisiert, und zusätzlich werden seine Kennzahlen komplementiert, so daß zum Komplement ähnliche Regionen als mögliche Docking-Stellen im Index gefunden werden können. In den nachfolgenden Filterschritten des Dockingsystems wird unter anderem das räumliche Passen genauer überprüft

Aptasensors for point-of-care detection of small molecules

Aptamers, a group of nucleic acids which can specifically bind to a target molecule, have drawn extensive interest over the past few decades. For analytics, aptamers represent a viable alternative to gold-standard antibodies due to their oligonucleic nature combined with advantageous properties, including higher stability in harsh environments and longer shelf-life. Indeed, over the last decade, aptamers have been used in numerous bioanalytical assays and in various point-of-care testing (POCT) platforms. The latter allows for rapid on-site testing and can be performed outside a laboratory by unskilled labor. Aptamer technology for POCT is not limited just to medical diagnostics; it can be used for a range of applications, including environmental monitoring and quality control. In this review, we critically examine the use of aptamers in POCT with an emphasis on their advantages and limitations. We also examine the recent success of aptasensor technology and how these findings pave the way for the analysis of small molecules in POCT and other health-related applications. Finally, the current major limitations of aptamers are discussed, and possible approaches for overcoming these challenges are presented. © 2020 by the authors

Assessment of measures of physical activity of children with cerebral palsy at home and school: a pilot study

ABSTRACTHome and school are important settings where children can accrue health promoting physical activity (PA). Little&nbsp;is known about the PA levels and associated environmental characteristics at home and school in children with&nbsp;cerebral palsy (CP). An observational tool - Behaviors of Eating and Activity for Children&rsquo;s Health Evaluation System&nbsp;(BEACHES) - offers potential for providing information.Objective: To validate BEACHES against Actigraph accelerometer and to document PA of children with CP at&nbsp;a special residential school facility for children with physical disabilities.Methods: Five children with CP (2 girls, 3 boys; aged 9.82 &plusmn; 2.39 years) in Level I of the Gross Motor Function&nbsp;Classification System (GMFCS) participated. PA monitoring was conducted once a week during four consecutive&nbsp;weeks at morning recess at school and during after school hours at the children&rsquo;s residence. Estimates of time&nbsp;spent being sedentary and being active were derived from the Actigraph and compared to estimates obtained with&nbsp;BEACHES.Results: Children&rsquo;s PA observed using BEACHES was comparable to the Actigraph estimations. In general,&nbsp;children were more active at recess than after school and the physical locations assessed by BEACHES were&nbsp;associated with objectively measured PA time.Conclusion: This pilot study indicates that BEACHES appears to be a suitable measure of PA for children with&nbsp;CP in both home and school settings. Additional study with a larger and more diverse sample is recommended to&nbsp;verify the results.</div

Semaine d'Etude Mathématiques et Entreprises 6 : Analyse et filtrage temps-fréquence de "bursts" ultrasonores : identification, classification, séparation

Ce rapport est une présentation de nos résultats et de nos réflexions à propos du problème proposé par IFP Énergies Nouvelles pendant la sixième édition de la Semaine d'Étude Maths-Entreprises. Nous disposions d'enregistrements de bursts ultrasonores issus d'un problème physique de corrosion d'éprouvettes en métal. Le but était de donner une classification des signaux acoustiques visant à identifier les différentes typologies de corrosion. En Section 1 on trouve une présentation plus détaillée de la problématique enquêtée. Tous les approches considérées sont développées dans la Section 3, alors que dans la Section 2 on a passé en revue les outils mathématiques nécessaires