Buprenorphine/naloxone maintenance therapy in patients with meperidine use disorder

Meperidine hydrochloride is a synthetic opioid and a weak µ receptor agonist. Meperidine use disorder is mostly iatrogenic and is common in health care workers. In addition, it is prescribed in acute and chronic pain complaints, and has a high potential for creating addiction. Treatment of meperidine use disorder is a challenging issue and there is no standardised treatment for meperidine addiction. Buprenorphine is a μ receptor partial agonist, a long-acting synthetic opioid for the treatment of opioid dependence and has a buprenorphine/naloxone (BN) form combined with naloxone. Buprenorphine maintenance therapy is one of the treatment options performed in opiate use disorder. But there is a paucity of data about treatment of meperidine use disorder. Here, a full remission case report is presented with BN maintenance treatment for a patient with meperidine use disorder diagnosis

Urinary extract profiles of illegal substances at psychiatry and dependency clinics: three years report

Background: Substance abuse is a serious problem all over the world. There are many studies report the illegal substance use profile but few studies present their toxicology laboratory analysis. This study reports a quantitative profile of (Urine Drug Screening)) for illegal substances in Sakarya-Turkey.Methods: This study presents the urine analysis of all illegal substances which were made in the laboratory of Sakarya Training Research Hospital between March 2012 and February 2015. The results obtained from socio-demographic data and urine tests of patients were analyzed by examining their hospital record files. Urine drug screening was conducted with immunoassay quantitative analysis.Results: People subjected to substance analysis (n=2948) ages vary between 12 and 76, their mean age was 28.30±9.46. 96.74% (n=2852) of them were males. Substance positivity was determined in 34.73% of all patients (n=1024/2948) and their ages varied between 14 and 70 and their mean age was 29.39±9.65. Distribution of the urine positivity of the substances contained: marijuana 79, 5% (n=814), amphetamine 30.17% (n=309), ecstasy 23.74% (n=199), benzodiazepine 9,1% (n=94), synthetic cannabinoid 4.9% (n=12/243); opioid 5.2% (n=54), cocaine 1.67% (n=14) and multiple substance 29.9% (n=308).Conclusions: According to this study, marijuana is the most frequently used substance and multiple substance use is common. Synthetic cannabinoid seems to take place rapidly among the users. Updating the kits is important to reach the correct information in drug screening tests

Case Report Delirium and High Creatine Kinase and Myoglobin Levels Related to Synthetic Cannabinoid Withdrawal

Synthetic cannabinoids (SCs) are included in a group of drugs called new psychoactive substances. Effects of SCs on the central nervous system are similar to other cannabinoids, but 2-100 times more potent than marijuana. Thus, addiction and withdrawal symptoms are more severe than natural cannabinoids. Withdrawal symptoms of SCs were reported in the literature previously. But there is no report about SC withdrawal delirium and its treatment. Several studies reported that agonists of CB1 receptors play a role in GABA and glutamatergic neurotransmission, which is similar to the effects of alcohol on GABA and glutamatergic receptors. Previous studies on alcohol delirium cases suggested that elevated creatine kinase (CK) can be a marker of progress. This study reports delirium and high serum CK levels related to SC withdrawal and offers a treatment with benzodiazepine for them. We described two cases treated in our inpatient clinic about SC withdrawal with increase of serum CK level and other laboratory parameters. One of them demonstrated delirium symptoms and the other did not with early rapid treatment

How often do women use non-drug treatment methods for psyschiatric symptoms during pregnancy and postpartum periods?

The aim of this study was to determine the prevalence of complementary and alternative medical applications (CAM) and non-drug treatments of women during their pregnancies, postpartum periods and the changes between these periods. The Screening Form for Non-pharmacologic Methods Used during Pregnancy and Postpartum period was administered to the participants. Passiflora (Incarnata), Hypericum perforatum (St. John’s Wort), omega 3 supplements, bright light treatment, transmagnetic stimulation, S-adenosyl- methionine, herbal teas, biofeedback/neurofeedback, amulets, exercise, acupuncture and psychotherapy were investigated. The ratio of the use of one of the CAM methods for psychiatric complaints during people’s lifetime was found to be 33.3% (n=162). Herbal teas were the main practice used during pregnancy (58.8%) and the postpartum. The use of CAM according to the utilization periods of the participants statistically significantly decreased in those who were currently pregnant (Cochran’s Q=298.007; P<0.05). The use of participants’ non-drug treatments in the periodical follow-up decreased in those who are currently pregnant and increased during the postpartum period

Investigating persistent scatterer InSAR (PSInSAR) technique efficiency for landslides mapping: a case study in Artvin dam area, in Turkey

Monitoring and determining landslides in dam reservoirs is very crucial as it is one of the main factors of dam failures in the world. Coruh river basin is one of the most important river basin in the Northeast part of Turkey which accompanies five big dams. Although persistent scatterer InSAR (PSInSAR) method is a powerful remote sensing technique which can measure and monitor displacements of the Earth’s surface over time, its validation is a challenging issue because of the heterogeneous PS data. In this study, the efficiency of PSInSAR is investigated by proposing two different validation methods in order to see the consistency of the determined mean deformation velocities obtained with series of Sentinel-1A SAR-images. In the first method, 3D coordinates of reference points are projected to 1D displacement values in line of sight direction and then compared with the radar displacements of PS points. In the second method, new displacement values of PS points around reference points are identified from an interpolation map in order to be compared with the original displacements of reference points. In the end, it is showed that the displacements found by PSInSAR method are consistent with the reference points’ displacements measured in the study area. Finally, this work’s specific objectives are to present solutions to the challenging validation problem, to show the effectiveness of PSInSAR method and to describe the remaining challenges in PS analysis of landslide applications in dam areas

A Comparative Examination of the Family-Based Early Intervention Programs Developed in Turkey and in the Usa in the Last Decade

Starting to be implemented as of the 1960s, early intervention programs are frequently employed at the present time. Researchers develop and implement early intervention programs in various subjects and areas. These programs may be family-based, school-based, community-based, or a combination of them. This study aimed at comparing the early intervention programs developed in the USA and in Turkey in the last decade in terms of duration, implementers, participants, implementation process, assessment tools, and effects. (C) 2015 The Authors. Published by Elsevier Ltd.Wo