932 research outputs found

    Van der Waals torque induced by external magnetic fields

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    We present a method for inducing and controlling van der Waals torques between two parallel slabs using a constant magnetic field. The torque is calculated using the Barash theory of dispersive torques. In III-IV semiconductors such as InSbInSb, the effect of an external magnetic field is to induce an optical anisotropy, in an otherwise isotropic material, that will in turn induce a torque. The calculations of the torque are done in the Voigt configuration, with the magnetic field parallel to the surface of the slabs. As a case study we consider a slab made of calcite and a second slab made of InSbInSb. In the absence of magnetic field there is no torque. As the magnetic field increases, the optical anisotropy of InSbInSb increases and the torque becomes different from zero, increasing with the magnetic field. The resulting torque is of the same order of magnitude as that calculated using permanent anisotropic materials when the magnetic fields is close to 1 T.Comment: to appear in Journal of Applied Physic

    Generalidades de la familia Filoviridae y el virus del Ébola: una actualización de sus implicaciones en la población humana

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    Characteristics of the family Filoviridae and the Ebola virus: an update of its implications in the human population The family Filoviridae is integrated by a group of filamentous RNA viruses that cause severe hemorrhagic fevers in primates and other mammals, including humans, mainly in the African continent. Ebolavirus, arburgrvirus and Lloviu cuevavirus are the members of this family, and their main reservoirs are bats from the family Pteropodidae. The present review describes the main characteristics of the Filoviruses, pathophysiology and epidemiology on the human population, with a focus on the Ebolavirus, a pathogen of great epidemiological importance responsible for the death of 13 293 people since 1976. The Ebola outbreak of 2014-2016 was the largest in history, with 28 652 cases, representing more than 90% of the total number of cases reported since the origin of the disease (31 685). The transmission of the virus between humans can happen directly, through ontaminated fluids, or indirectly, by parenteral transmission and fomites. The incubation period ranges from 2 to 21 days and the symptomatology is divided in four phases: a febrile phase with nonspecific symptoms, a phase characterized by gastrointestinal symptoms, and two with the presence of critical symptoms. Although there is no specific treatment for the Ebola virus disease, the development of potential vaccines is currently underway, and some have showed positive results in animal models. This could lead to the appearance of an effective treatment that increases the survival of infected patients, and better epidemiological control

    Liver transplantation for arteriohepatic dysplasia (Alagille's syndrome)

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    Thirteen out of 268 children (<18 years old) underwent hepatic transplantation (OLT) for end-stage liver disease (ESLD) associated with arteriohepatic dysplasia (AHD). Seven children are alive and well with normal liver function. Six children died, four within 11 days of the operation and the other two at 4 and 10 months after the OLT. Vascular complications with associated septicemia were responsible for the deaths of three children. Two died of heart failure and circulatory collapse, secondary to pulmonary hypertension and congenital heart disease. The remaining patient died of overwhelming sepsis not associated with technical complications. Seven patients had a portoenterostomy or portocholecystostomy early in life; five of these died after the OLT. Severe cardiovascular abnormalities in some of our patients suggest that complete hemodynamic monitoring with invasive studies should be performed in all patients with AHD, especially in cases of documented hypertrophy of the right ventricle. The improved quality of life in our surviving patients confirms the validity of OLT as a treatment of choice in cases of ESLD due to AHD. © 1992 Springer-Verlag

    Nonlocal impedances and the Casimir entropy at low temperatures

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    The problem with the temperature dependence of the Casimir force is investigated. Specifically, the entropy behavior in the low temperature limit, which caused debates in the literature, is analyzed. It is stressed that the behavior of the relaxation frequency in the T0T\to0 limit does not play a physical role since the anomalous skin effect dominates in this range. In contrast with the previous works, where the approximate Leontovich impedance was used for analysis of nonlocal effects, we give description of the problem in terms of exact nonlocal impedances. It is found that the Casimir entropy is going to zero at T0T\to0 only in the case when ss polarization does not contribute to the classical part of the Casimir force. However, the entropy approaching zero from the negative side that, in our opinion, cannot be considered as thermodynamically satisfactory. The resolution of the negative entropy problem proposed in the literature is analyzed and it is shown that it cannot be considered as complete. The crisis with the thermal Casimir effect is stressed.Comment: Accepted in Phys. Rev.

    Computation of Casimir forces for dielectrics or intrinsic semiconductors based on the Boltzmann transport equation

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    The interaction between drifting carriers and traveling electromagnetic waves is considered within the context of the classical Boltzmann transport equation to compute the Casimir-Lifshitz force between media with small density of charge carriers, including dielectrics and intrinsic semiconductors. We expand upon our previous work [Phys. Rev. Lett. {\bf 101}, 163203 (2008)] and derive in some detail the frequency-dependent reflection amplitudes in this theory and compute the corresponding Casimir free energy for a parallel plate configuration. We critically discuss the the issue of verification of the Nernst theorem of thermodynamics in Casimir physics, and explicity show that our theory satisfies that theorem. Finally, we show how the theory of drifting carriers connects to previous computations of Casimir forces using spatial dispersion for the material boundaries.Comment: 9 pages, 2 figures; Contribution to Proceedings of "60 Years of the Casimir Effect", Brasilia, June 200

    Casimir-like tunneling-induced electronic forces

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    We study the quantum forces that act between two nearby conductors due to electronic tunneling. We derive an expression for these forces by calculating the flux of momentum arising from the overlap of evanescent electronic fields. Our result is written in terms of the electronic reflection amplitudes of the conductors and it has the same structure as Lifshitz's formula for the electromagnetically mediated Casimir forces. We evaluate the tunneling force between two semiinfinite conductors and between two thin films separated by an insulating gap. We discuss some applications of our results.Comment: 8 pages, 3 figs, submitted to Proc. of QFEXT'05, to be published in J. Phys.

    Causes of death after liver transplantation in children treated with cyclosporine and steroids

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    Two-hundred-and-twenty-seven children underwent orthotopic liver transplantation between March 1980 and March 1986. Seventy (31%) patients died during the study period. Four patients who died within 24 hours of the initial liver transplant and 5 patients who died outside of our institution were excluded from the analysis. Liver failure, related to either thrombosis of the hepatic artery, primary non-function of the graft or rejection accounted for 25 of the remaining 61 deaths. In 21 patients death was related to overwheming sepsis while 7 patients died from excessive bleeding. Eight of the deaths were due to a miscellaneous group of causes. Twenty percent of the 150 patients who received a single liver transplant died compared to a death rate of 50% in patients who underwent three transplants. Eighty-five percent of the deaths occurred within 6 months after the initial liver transplant. Liver failure was the cause in the majority of the early deaths whereas the later deaths were more likely to be due to sepsis. This detailed analysis of the causes of death after pediatric liver transplantation in a large group of patients has revealed that advances in certain areas could lead to even better results

    Vacuum fluctuation force on a rigid Casimir cavity in a gravitational field

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    We discuss the possibility of verifying the equivalence principle for the zero-point energy of quantum electrodynamics, by evaluating the force, produced by vacuum fluctuations, acting on a rigid Casimir cavity in a weak gravitational field. The resulting force has opposite direction with respect to the gravitational acceleration; the order of magnitude for a multi-layer cavity configuration is derived and experimental feasibility is discussed, taking into account current technological resources.Comment: 13 pages, Latex. In the revised version, the presentation has been improve

    Evaluation of multiple protein docking structures using correctly predicted pairwise subunits

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    <p>Abstract</p> <p>Background</p> <p>Many functionally important proteins in a cell form complexes with multiple chains. Therefore, computational prediction of multiple protein complexes is an important task in bioinformatics. In the development of multiple protein docking methods, it is important to establish a metric for evaluating prediction results in a reasonable and practical fashion. However, since there are only few works done in developing methods for multiple protein docking, there is no study that investigates how accurate structural models of multiple protein complexes should be to allow scientists to gain biological insights.</p> <p>Methods</p> <p>We generated a series of predicted models (decoys) of various accuracies by our multiple protein docking pipeline, Multi-LZerD, for three multi-chain complexes with 3, 4, and 6 chains. We analyzed the decoys in terms of the number of correctly predicted pair conformations in the decoys.</p> <p>Results and conclusion</p> <p>We found that pairs of chains with the correct mutual orientation exist even in the decoys with a large overall root mean square deviation (RMSD) to the native. Therefore, in addition to a global structure similarity measure, such as the global RMSD, the quality of models for multiple chain complexes can be better evaluated by using the local measurement, the number of chain pairs with correct mutual orientation. We termed the fraction of correctly predicted pairs (RMSD at the interface of less than 4.0Å) as <it>fpair </it>and propose to use it for evaluation of the accuracy of multiple protein docking.</p
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