Single electron transistor strongly coupled to vibrations: Counting Statistics and Fluctuation Theorem

Using a simple quantum master equation approach, we calculate the Full Counting Statistics of a single electron transistor strongly coupled to vibrations. The Full Counting Statistics contains both the statistics of integrated particle and energy currents associated to the transferred electrons and phonons. A universal as well as an effective fluctuation theorem are derived for the general case where the various reservoir temperatures and chemical potentials are different. The first relates to the entropy production generated in the junction while the second reveals internal information of the system. The model recovers Franck-Condon blockade and potential applications to non-invasive molecular spectroscopy are discussed.Comment: extended discussion, to appear in NJ

Transport in molecular states language: Generalized quantum master equation approach

A simple scheme capable of treating transport in molecular junctions in the language of many-body states is presented. An ansatz in Liouville space similar to generalized Kadanoff-Baym approximation is introduced in order to reduce exact equation-of-motion for Hubbard operator to quantum master equation (QME)-like expression. A dressing with effective Liouville space propagation similar to standard diagrammatic dressing approach is proposed. The scheme is compared to standard QME approach, and its applicability to transport calculations is discussed within numerical examples.Comment: 10 pages, 3 figure

One-Loop Divergences in Simple Supergravity: Boundary Effects

This paper studies the semiclassical approximation of simple supergravity in Riemannian four-manifolds with boundary, within the framework of $\zeta$-function regularization. The massless nature of gravitinos, jointly with the presence of a boundary and a local description in terms of potentials for spin ${3\over 2}$, force the background to be totally flat. First, nonlocal boundary conditions of the spectral type are imposed on spin-${3\over 2}$ potentials, jointly with boundary conditions on metric perturbations which are completely invariant under infinitesimal diffeomorphisms. The axial gauge-averaging functional is used, which is then sufficient to ensure self-adjointness. One thus finds that the contributions of ghost and gauge modes vanish separately. Hence the contributions to the one-loop wave function of the universe reduce to those $\zeta(0)$ values resulting from physical modes only. Another set of mixed boundary conditions, motivated instead by local supersymmetry and first proposed by Luckock, Moss and Poletti, is also analyzed. In this case the contributions of gauge and ghost modes do not cancel each other. Both sets of boundary conditions lead to a nonvanishing $\zeta(0)$ value, and spectral boundary conditions are also studied when two concentric three-sphere boundaries occur. These results seem to point out that simple supergravity is not even one-loop finite in the presence of boundaries.Comment: 37 pages, Revtex. Equations (5.2), (5.3), (5.5), (5.7), (5.8) and (5.13) have been amended, jointly with a few misprint

On the Zero-Point Energy of a Conducting Spherical Shell

The zero-point energy of a conducting spherical shell is evaluated by imposing boundary conditions on the potential, and on the ghost fields. The scheme requires that temporal and tangential components of perturbations of the potential should vanish at the boundary, jointly with the gauge-averaging functional, first chosen of the Lorenz type. Gauge invariance of such boundary conditions is then obtained provided that the ghost fields vanish at the boundary. Normal and longitudinal modes of the potential obey an entangled system of eigenvalue equations, whose solution is a linear combination of Bessel functions under the above assumptions, and with the help of the Feynman choice for a dimensionless gauge parameter. Interestingly, ghost modes cancel exactly the contribution to the Casimir energy resulting from transverse and temporal modes of the potential, jointly with the decoupled normal mode of the potential. Moreover, normal and longitudinal components of the potential for the interior and the exterior problem give a result in complete agreement with the one first found by Boyer, who studied instead boundary conditions involving TE and TM modes of the electromagnetic field. The coupled eigenvalue equations for perturbative modes of the potential are also analyzed in the axial gauge, and for arbitrary values of the gauge parameter. The set of modes which contribute to the Casimir energy is then drastically changed, and comparison with the case of a flat boundary sheds some light on the key features of the Casimir energy in non-covariant gauges.Comment: 29 pages, Revtex, revised version. In this last version, a new section has been added, devoted to the zero-point energy of a conducting spherical shell in the axial gauge. A second appendix has also been include

One-Loop Effective Action for Euclidean Maxwell Theory on Manifolds with Boundary

This paper studies the one-loop effective action for Euclidean Maxwell theory about flat four-space bounded by one three-sphere, or two concentric three-spheres. The analysis relies on Faddeev-Popov formalism and $\zeta$-function regularization, and the Lorentz gauge-averaging term is used with magnetic boundary conditions. The contributions of transverse, longitudinal and normal modes of the electromagnetic potential, jointly with ghost modes, are derived in detail. The most difficult part of the analysis consists in the eigenvalue condition given by the determinant of a $2 \times 2$ or $4 \times 4$ matrix for longitudinal and normal modes. It is shown that the former splits into a sum of Dirichlet and Robin contributions, plus a simpler term. This is the quantum cosmological case. In the latter case, however, when magnetic boundary conditions are imposed on two bounding three-spheres, the determinant is more involved. Nevertheless, it is evaluated explicitly as well. The whole analysis provides the building block for studying the one-loop effective action in covariant gauges, on manifolds with boundary. The final result differs from the value obtained when only transverse modes are quantized, or when noncovariant gauges are used.Comment: 25 pages, Revte

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages

Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype. Both glioma and infiltrating M/MΦ cells express the Ca(2+)-activated K(+) channel (KCa3.1), and the inhibition of KCa3.1 activity on glioma cells reduces tumor infiltration in the healthy brain parenchyma. We wondered whether KCa3.1 inhibition could prevent the acquisition of a pro-tumor phenotype by M/MΦ cells, thus contributing to reduce glioma development. With this aim, we studied microglia cultured in glioma-conditioned medium or treated with IL-4, as well as M/MΦ cells acutely isolated from glioma-bearing mice and from human glioma biopsies. Under these different conditions, M/MΦ were always polarized toward an anti-inflammatory state, and preventing KCa3.1 activation by 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole (TRAM-34), we observed a switch toward a pro-inflammatory, antitumor phenotype. We identified FAK and PI3K/AKT as the molecular mechanisms involved in this phenotype switch, activated in sequence after KCa3.1. Anti-inflammatory M/MΦ have higher expression levels of KCa3.1 mRNA (kcnn4) that are reduced by KCa3.1 inhibition. In line with these findings, TRAM-34 treatment, in vivo, significantly reduced the size of tumors in glioma-bearing mice. Our data indicate that KCa3.1 channels are involved in the inhibitory effects exerted by the glioma microenvironment on infiltrating M/MΦ, suggesting a possible role as therapeutic targets in glioma

Fluctuation theorem for counting-statistics in electron transport through quantum junctions

We demonstrate that the probability distribution of the net number of electrons passing through a quantum system in a junction obeys a steady-state fluctuation theorem (FT) which can be tested experimentally by the full counting statistics (FCS) of electrons crossing the lead-system interface. The FCS is calculated using a many-body quantum master equation (QME) combined with a Liouville space generating function (GF) formalism. For a model of two coupled quantum dots, we show that the FT becomes valid for long binning times and provide an estimate for the finite-time deviations. We also demonstrate that the Mandel (or Fano) parameter associated with the incoming or outgoing electron transfers show subpoissonian (antibunching) statistics.Comment: 20 pages, 12 figures, accepted in Phy.Rev.

Heat kernel coefficients for chiral bag boundary conditions

We study the asymptotic expansion of the smeared L2-trace of fexp(-tP^2) where P is an operator of Dirac type, f is an auxiliary smooth smearing function which is used to localize the problem, and chiral bag boundary conditions are imposed. Special case calculations, functorial methods and the theory of zeta and eta invariants are used to obtain the boundary part of the heat-kernel coefficients a1 and a2.Comment: Published in J. Phys. A38, 2259-2276 (2005). Record without file already exists on the SLAC recor