Prevención de la Influenza Aviar en la Argentina : Diagnóstico, vacunas y plan de contingencia

Se realizó una breve relación histórica de la enfermedad y luego se definieron las características del virus de IA destacando sus componentes proteicos de superficie, las hemoaglutininas “H” y las neuroaminidasas “N”, que determinan sus numerosos subtipos. (Láminas 1 a 3). Se describió la difusión de la IA en el mundo, sus características epidemiológicas y su relación ecológica, destacando su alta difusión en distintas épocas y diversas regiones. (Láminas 4 a 5). Se desarrollaron los conceptos que deben primar en la prevención de la enfermedad, basados en su patogenia y transmisión. El control de importaciones, control de desechos en el tránsito internacional, controles de bioseguridad en granjas agrícolas, además de la capacitación y entrenamiento de técnicos y avicultores. (Láminas 6 a 14). Se refirió a las medidas de contención, y la necesidad de habilidades y desarrollo laboratorial para poder realizar el diagnóstico precoz, como forma de contrarrestar la alta difusión de la IA. (Láminas 15 a 17). Se relataron los resultados de la vigilancia epidemiológica obtenidos por SENASA en diversas encuestas serológicas, que se viene realizando desde 1999 a 2005. (Láminas 18 a 19). Además se refirió al Plan de contingencia que prevé las normas para controlar la enfermedad en caso de su eventual ocurrencia y explicó los entrenamiento con simulacros de aparición de la enfermedad, para adiestramiento del personal de SENASA. (Láminas 20 a 32).Academia Nacional de Agronomía y Veterinaria (ANAV

Reseña sobre vigilancia y prevención de la influenza aviar y rol zoonótico

En el trabajo se tratan los siguientes temas: Influenza aviar Rol zoonótico del virus de la peste aviaria Ubicación y características de los virus influenza Replicación Patogénesis Cuadro clínico Prevención y profilaxis Diagnóstico de laboratorio Declaración de Brasilia. Conferencia hemisférica de vigilancia y prevención de la influenza aviar, Brasilia, Brasil, 2 de diciembre de 2005Facultad de Ciencias Veterinaria

Huarique APP

A consecuencia de la crisis sanitaria que vive el país, el gobierno optó por cerrar las operaciones de atención al público en los restaurantes, lo que sin duda afectó drásticamente los ingresos y proyecciones de crecimiento del sector (Gobierno del Perú, 2020 y Rpp, 2020). En consecuencia, reabrir y mantenerse activo les ha significado un aumento de sus costos, ya que deben cumplir con todas las medidas de protección sanitaria que exige la norma, a pesar de ello las ventas de los meses anteriores han sido bajas, lo que afectó a todos los restaurantes y en específico a aquellos pequeños establecimientos como son los huariques. En la actualidad, estos huariques tampoco tienen el capital necesario para implementar nuevas herramientas tecnológicas o tener un servicio de delivery con mayor alcance. Por ello, se creó a “Huarique app”, una aplicación móvil para apoyar a todos estos huariques que han reducido el volumen de sus pedidos y buscan posicionar su marca en el mercado. En ese sentido, la empresa funcionará como un intermediario entre estos huariques y los consumidores de Lima Metropolitana para ubicar el establecimiento preferido y solicitar sus pedidos para el desayuno, almuerzo o cena, y con opción de delivery. Finalmente, luego de analizar los flujos de caja de cinco años para conocer los indicadores de rentabilidad, se demostró que este es un negocio sumamente rentable, viable y generador de valor en el tiempo, con buenas proyecciones para expandirse a todo el Perú y a nivel internacional.As a result of the health crisis that the country is experiencing, the government opted to close the customer service operations in restaurants, which undoubtedly drastically affected the sector's income and growth projections (Government of Peru, 2020 and Rpp, 2020). Consequently, reopening and staying active has meant an increase in their costs, since they must comply with all the sanitary protection measures required by the standard, despite this, sales in the previous months have been low, which affected all restaurants and specifically those small establishments such as the huariques. Currently, these huariques do not have the necessary capital to implement new technological tools or have a delivery service with greater scope. For this reason, the “Huarique app” was created, a mobile application to support all these huariques that have reduced the volume of their orders and seek to position their brand in the market. In this sense, the company will function as an intermediary between these huariques and the consumers of Lima Metropolitana to locate the preferred establishment and request their orders for breakfast, lunch or dinner, and with the option of delivery. Finally, after analyzing the cash flows of five years to know the profitability indicators, it was shown that this is an extremely profitable, viable business and a generator of value over time, with good projections to expand throughout Peru and internationally.Trabajo de investigació

A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer's disease

The key role played by host-microbiota interactions on human health, disease onset and progression, and on host response to treatments has increasingly emerged in the latest decades. Indeed, dysbiosis has been associated to several human diseases such as obesity, diabetes, cancer and also neurodegenerative disease, such as Parkinson, Huntington and Alzheimer's disease (AD), although whether causative, consequence or merely an epiphenomenon is still under investigation. In the present study, we performed a metabologenomic analysis of stool samples from a mouse model of AD, the 3xTgAD. We found a significant change in the microbiota of AD mice compared to WT, with a longitudinal divergence of the F/B ratio, a parameter suggesting a gut dysbiosis. Moreover, AD mice showed a significant decrease of some amino acids, while data integration revealed a dysregulated production of desaminotyrosine (DAT) and dihydro-3-coumaric acid. Collectively, our data show a dysregulated gut microbiota associated to the onset and progression of AD, also indicating that a dysbiosis can occur prior to significant clinical signs, evidenced by early SCFA alterations, compatible with gut inflammation

Mosquito trap results from Palmyra Atoll, by date, island and trap type from Local extinction of the Asian tiger mosquito (<i>Aedes albopictus</i>) following rat eradication on Palmyra Atoll

Mosquito trap dat

Annual rainfall on Palmyra Atoll taken from the station rain gauge from Local extinction of the Asian tiger mosquito (<i>Aedes albopictus</i>) following rat eradication on Palmyra Atoll

Rainfall dat

Modeling mosquito abundance as a function of two host densities from Local extinction of the Asian tiger mosquito (<i>Aedes albopictus</i>) following rat eradication on Palmyra Atoll

Modeling mosquito abundanc

Sampling locations, types, and effort for mosquitoes before and after rat eradication from Local extinction of the Asian tiger mosquito (<i>Aedes albopictus</i>) following rat eradication on Palmyra Atoll

Sample location

Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p&lt;0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p&lt;0·0001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status