7,538 research outputs found

    Treatment of ankle osteoarthritis: arthrodesis versus total ankle replacement

    Get PDF
    While ankle arthrodesis has remained the gold standard treatment for symptomatic primary, secondary, and posttraumatic ankle arthritis, more recently, total ankle replacement (TAR) has seen considerable improvement in terms of biomechanics, function, and complication rates. However, while in the long-term degeneration of the adjacent joints is almost always found on radiographs after ankle arthrodesis, the longevity of TAR is still insufficient and does not match that of total knee and hip joints. The current review article focuses on the treatment of ankle arthritis by means of arthrodesis and TA

    Sprunggelenkarthrodese nach gescheiterter Endoprothesenimplantation

    Get PDF
    Zusammenfassung: Trotz anatomischer und biomechanischer Verbesserungen bleibt die Langzeitprognose oberer Sprunggelenkendoprothesen hinsichtlich der Überlebensrate problematisch. Bei fehlgeschlagener oberer Sprunggelenkendoprothesenimplantation stellt die Konversion in eine obere Sprunggelenkarthrodese eine zuverlässige Behandlungsmethode dar. Trotzdem ist die Durchführung aufgrund der Knochendefekte, des prekären Weichteilzustands und auch Erhaltung der Beinlänge technisch anspruchsvoll und aufwendig. Es besteht das Potenzial zu erheblichen Einschränkungen der Lebensqualität als auch Gesamtfunktion des Fuß- und Sprunggelenks. Der vorliegende Artikel behandelt das Thema der Arthrodese nach gescheiterter oberer Sprunggelenkendoprothesenimplantation und schlägt Algorithmen für die Therapie vo

    Why do borrowers pledge collateral? new empirical evidence on the role of asymmetric information

    Get PDF
    An important theoretical literature motivates collateral as a mechanism that mitigates adverse selection, credit rationing, and other inefficiencies that arise when borrowers hold ex ante private information. There is no clear empirical evidence regarding the central implication of this literature—that a reduction in asymmetric information reduces the incidence of collateral. We exploit exogenous variation in lender information related to the adoption of an information technology that reduces ex ante private information, and compare collateral outcomes before and after adoption. Our results are consistent with this central implication of the private-information models and support the empirical importance of this theory.

    Debt maturity, risk, and asymmetric information

    Get PDF
    We test the implications of Flannery’s (1986) and Diamond’s (1991) models concerning the effects of risk and asymmetric information in determining debt maturity, and we examine the overall importance of informational asymmetries in debt maturity choices. We employ data from more than 6,000 commercial loans from 53 large U.S. banks. Our results for low-risk firms are consistent with the predictions of both theoretical models, but our findings for high-risk firms conflict with the predictions of Diamond’s model and with much of the empirical literature. Our findings also suggest a strong quantitative role for asymmetric information in explaining debt maturity.

    A haloarchaeal ferredoxin electron donor that plays an essential role in nitrate assimilation

    Get PDF
    In the absence of ammonium, many organisms, including the halophilic archaeon Haloferax volcanii DS2 (DM3757), may assimilate inorganic nitrogen from nitrate or nitrite, using a ferredoxin-dependent assimilatory NO3-/NO2- reductase pathway. The small acidic ferredoxin Hv-Fd plays an essential role in the electron transfer cascade required for assimilatory nitrate and nitrite reduction by the cytoplasmic NarB- and NirA-type reductases respectively. UV–visible absorbance and EPR spectroscopic characterization of purified Hv-Fd demonstrate that this protein binds a single [2Fe–2S] cluster, and potentiometric titration reveals that the cluster shares similar redox properties with those present in plant-type ferredoxins
    • …
    corecore