Ruxolitinib in refractory acute and chronic graft-versus-host disease : a multicenter survey study

Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. First-line treatment is based on the use of high doses of corticosteroids. Unfortunately, second-line treatment for both acute and chronic graft-versus-host disease, remains a challenge. Ruxolitinib has been shown as an effective and safe treatment option for these patients. Seventy-nine patients received ruxolitinib and were evaluated in this retrospective and multicenter study. Twenty-three patients received ruxolitinib for refractory acute graft-versus-host disease after a median of 3 (range 1-5) previous lines of therapy. Overall response rate was 69.5% (16/23) which was obtained after a median of 2 weeks of treatment, and 21.7% (5/23) reached complete remission. Fifty-six patients were evaluated for refractory chronic graft-versus-host disease. The median number of previous lines of therapy was 3 (range 1-10). Overall response rate was 57.1% (32/56) with 3.5% (2/56) obtaining complete remission after a median of 4 weeks. Tapering of corticosteroids was possible in both acute (17/23, 73%) and chronic graft-versus-host disease (32/56, 57.1%) groups. Overall survival was 47% (CI: 23-67%) at 6 months for patients with aGVHD (62 vs 28% in responders vs non-responders) and 81% (CI: 63-89%) at 1 year for patients with cGVHD (83 vs 76% in responders vs non-responders). Ruxolitinib in the real life setting is an effective and safe treatment option for GVHD, with an ORR of 69.5% and 57.1% for refractory acute and chronic graft-versus-host disease, respectively, in heavily pretreated patients

Liberal governmentality in Spain: bodies, minds, and the medical construction of the “outsider,” 1870–1910

This paper traces the fragility of the subject in the period extending from the aftermath of the Sexenio through to the early twentieth century. In particular, two case studies are focused upon: the question of gender “deviance” and the figure of the genius, in order to understand how medicine participated in the construction of “outsider” identities within the context of the emerging liberal order. How did liberal rationales exclude or curtail certain wayward expressions of identity and subjectivity? What consequences did the marking of “excessive” figures or outsiders have for notions of inclusiveness and citizenship within the late-nineteenth-century liberal order? By concentrating primarily on medical texts and journals published during the period, this study builds on existing research to tease out answers to these questions

Orden legal y orden sexual en los comienzos de la Revolución Septembrina (1868-1870)

The article analyses the new constitutional and legal framework created from the Spanish Revolution of 1868 from a gender point of view, to answer if the Gloriosa meant any change in the legal system for the Spanish women that supposed some extension of rights for them. The Constitution itself (1869) and laws such as the Civil Marriage or the Penal Code (1870) provoked debates inside and outside the Chamber that expressed the orientation and reach of the associated meaning to the relationship between the sexes. All this, while the attitude of some Spanish women showed an intention of reaching unexplored spaces to date. The revolution will be seen as a great educational and associative opportunity for women, an awakening of their political conscience in favour of their citizenship rights.El artículo analiza el nuevo marco constitucional y jurídico creado a partir de la Revolución de 1868 desde el punto de vista de género, para responder si la Gloriosa significó cambio alguno en el ordenamiento legal para las españolas que supusiera alguna ampliación de derechos para ellas. La propia Constitución (1869) y leyes tales como la de Matrimonio Civil o el nuevo Código Penal (1870) suscitaron debates dentro y fuera de la Cámara que manifestaron la orientación y alcance de los significados asociados a la relación entre los sexos. Todo ello, cuando la actitud de algunas españolas evidenciaba la intención de alcanzar espacios inexplorados hasta la fecha. La Revolución será vista como una gran oportunidad educativa y asociativa para las mujeres. Un despertar de la conciencia política de las mismas en pro de sus derechos de ciudadanía