Dietary glycemic index and glycemic load in relation to mortality from cardiovascular disease: a review of epidemiologic evidence

زمینه و هدف: در طول دهه‌های گذشته، همواره بیماری‌های قلبی عروقی به عنوان اولین عامل مرگ و میر در سراسر دنیا شناخته شده است. تغییرات نامناسب در الگوی رژیم غذایی، از جمله افزایش مصرف کربوهیدرات‌های تصفیه شده با نمایه گلیسمیک (GI: Glycemic index) و بار گلیسمیک (GL: Glycemic Load) بالا، از مهمترین عوامل خطرزای محیطی در افزایش بیماری‌های قلبی عروقی است. این مطالعه با هدف مروری بر مطالعات پیشین، جهت بررسی ارتباط بین GI و GL رژیم غذایی و مرگ و میر ناشی از انواع بیماری‌های قلبی عروقی انجام شده است. روش بررسی: در این مطالعه مروری با جستجو در PubMed با کلید واژه‌های Glycemic index ، Cardiovascular disease (CVD) و mortality صورت گرفت. تا کنون مطالعات محدودی در این زمینه انجام شده که روش‌ها و نتایج حاصل از این مطالعات در این مقاله مورد بررسی قرار گرفته است. تمام مطالعات انجام شده، از نوع بررسی‌های آینده‌نگر بوده که بر روی انسان انجام شده است. یافته‌ها: نتایج مطالعات حاکی از آن است که ارتباط بین GI و GL رژیم غذایی و مرگ و میر بیماری‌های قلبی عروقی، معنی دار نبوده و تنها در زنان میانسال و مسن ژاپنی، ارتباط مثبت و معنی داری بین GI و GL رژیم غذایی و مرگ و میر ناشی از سکته اسکیمیک (خطر نسبی: 45/2 و فاصله اطمینان 95: 01/1 تا 92/5) مشاهده شده است. نتیجه‌گیری: نتیجه‌گیری بر اساس شواهد و یافته‌های موجود کار دشواری است و تعیین چگونگی ارتباط بین نمایه‌گلیسمیک و بارگلیسمیک رژیم غذایی و مرگ و میر ناشی از انواع بیماریهای قلبی و عروقی، نیازمند مطالعه و تحقیقات بیشتر، در این زمینه است

A case-control study of the relationship between gastric cancer and meat consumption in Iran

Background: Despite the descending trends of gastric cancer in many parts of the world, its mortality rate has still remained high globally. Meat, red and processed meat in particular, may induce gastric carcinogenesis through potential mechanisms. However, the role of this dietary aspect in the risk of gastric cancer has not well been investigated so far. Therefore, we designed a study to assess the relation between meat consumption and the risk of gastric cancer in Golestan Province, a high- risk area for gastric malignancies in Iran. Methods: Subjects of this population-based case-control study included 190 histologically confirmed case so fgastric cancer and 647 controls. Meat consumption was evaluated using a 116-item semi-quantitative food frequency questionnaire. A lifestyle questionnaire also collected data concerning demographic features, anthropometric measures, and other known risk factors of gastric cancer. We estimated crude and adjust edoddsratios(ORs) and 95 confidence intervals (CIs) for the relation between meat intake and gastric cancer. Results: After being adjusted for potential confounders, red meat intake was positively associated with gastric cancer which reached statistical significance (OR=1.87, 95 CI: 1.01-3.47, Ptrend = 0.07). On the other hand, individuals in the highest quartile of white meat consumption had astatistically significant reduced risk of gastric cancer compared to those in the lowest quartile (OR = 0.36, 95 CI: 0.19-0.68, Ptrend = 0.005). Conclusions: We observed a positive association between red meat consumption and the risk of gastric cancer, and a reverse relationship regarding white meat intake and the risk of this malignancy

A dish-based semi-quantitative food frequency questionnaire for assessment of dietary intakes in epidemiologic studies in Iran: design and development

BACKGROUND: Earlier forms of food frequency questionnaire (FFQ) used in Iran have extensive lists of foods, traditional categories and food-based design, mostly with the interviewer-administered approach. The aim of the current paper is to describe the development of a dish-based, machine-readable, semi-quantitative food frequency questionnaire (DFQ). METHODS: Within the framework of the Study on the Epidemiology of Psychological, Alimentary Health and Nutrition project, we created a novel FFQ using Harvard FFQ as a model. RESULTS: THE FOLLOWING STEPS WERE TAKEN TO DEVELOP THE QUESTIONNAIRE: Construction of a list of commonly consumed Iranian foods, definition of portion sizes, design of response options for consumption frequency of each food item and finally a pilot test of the preliminary DFQ. From a comprehensive list of foods and mixed dishes, we included those that were nutrient-rich, consumed reasonably often or contributed to between-person variations. We focused on mixed dishes, rather than their ingredients, along with foods. To shorten the list, the related food items or mixed dishes were categorized together in one food group. These exclusions resulted in a list of 106 foods or dishes in the questionnaire. The portion sizes used in the FFQ were obtained from our earlier studies that used dietary recalls and food records. The frequency response options for the food list varied from 6-9 choices from "never or less than once a month" to "12 or more times per day". CONCLUSIONS: The DFQ could be a reasonable dietary assessment tool for future epidemiological studies in the country. Validation studies are required to assess the validity and reliability of this newly developed questionnaire.AH Keshteli, Ahmad Esmaillzadeh, Somayeh Rajaie, Gholamreza Askari, Christine Feinle-Bisset and Peyman Adib

Combined Fruit and Vegetable Intake Is Correlated with Improved Inflammatory and Oxidant Status from a Cross-Sectional Study in a Community Setting

Previous studies have examined the relationship between specific nutrient and food intakes with limited markers of either inflammation or oxidant status. The objective of this study was to determine if an increase in combined self-reported fruit and vegetable (F&V) intake in a community setting was associated with improved multiple markers of inflammatory and oxidant status. A community group (N = 1000, age 18–85 years, 61% female) gave two fasted blood samples separated by 12 weeks. Blood inflammatory biomarkers included total leukocytes (WBC), plasma C-reactive protein (CRP), interleukin-6 (IL-6), IL-10, tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1, and granulocyte colony stimulating factor. Measured oxidant status markers were ferric reducing ability of plasma (FRAP), oxygen radical absorbance capacity (ORAC) and plasma F2-isoprostanes. The relation of markers across categories of F&V intake was examined. In analyses controlling for other important dietary and lifestyle factors, IL-6 and TNF-α were significantly lower across categories of increasing F&V intakes (p < 0.008). FRAP and ORAC were significantly higher (p < 0.0001 and p = 0.047 respectively) while F2-isoprostanes was significantly lower (p < 0.0001) across F&V categories. In a community study, several markers of both inflammation and oxidant status were associated in a putatively salutary direction by higher intake of combined F&V, supporting current guidelines suggesting increased F&V consumption for the prevention of chronic diseases

Empirically derived dietary patterns in relation to psychological disorders

Objective Psychological disorders are highly prevalent worldwide. The present study aimed to investigate the relationship between major dietary patterns and prevalence of psychological disorders in a large sample of Iranian adults. Design A cross-sectional study was done to identify dietary patterns derived from factor analysis. Dietary data were collected through the use of a validated dish-based semi-quantitative FFQ. Psychological health was examined by use of the Hospital Anxiety and Depression Scale and the General Health Questionnaire. Setting The study was conducted in Isfahan, Iran, within the framework of the Study on Epidemiology of Psychological, Alimentary Health and Nutrition (SEPAHAN). Subjects Iranian adults (n 3846) aged 20-55 years. Results After adjustment for potential confounders, greater adherence to the lacto-vegetarian dietary pattern was protectively associated with depression in women (OR=0·65; 95 CI 0·46, 0·91). Normal-weight participants in the top quintile of this dietary pattern tended to have decreased odds of anxiety compared with those in the bottom quintile (OR=0·61; 95 CI 0·38, 1·00). In addition, the traditional dietary pattern was associated with increased odds of depression (OR=1·42; 95 CI 1·01, 1·99) and anxiety (OR=1·56; 95 CI 1·00, 2·42) in women. Normal-weight participants in the highest quintile of the traditional dietary pattern had greater odds for anxiety (OR=1·89; 95 CI 1·12, 3·08) compared with those in the lowest quintile. The Western dietary pattern was associated with increased odds of depression in men (OR=1·73; 95 CI 1·07, 2·81) and anxiety in normal-weight participants (OR=2·05; 95 CI 1·22, 3·46). There was a significant increasing trend in the odds of psychological distress across increasing quintiles of the fast food dietary pattern in women (P-trend=0·02). Conclusions Recommendation to increase the intake of fruits, citrus fruits, vegetables, tomato and low-fat dairy products and to reduce the intakes of snacks, high-fat dairy products, chocolate, carbonated drinks, sweets and desserts might be associated with lower chance of psychological disorders. © 2015 The Authors

Effects of the Dietary Approaches to Stop Hypertension (DASH) Eating Plan on Cardiovascular Risks Among Type 2 Diabetic Patients: A randomized crossover clinical trial

Objective: To determine the effects of the Dietary Approaches to Stop Hypertension (DASH) eating pattern on cardiometabolic risks in type 2 diabetic patients. Research design and methods: A randomized crossover clinical trial was undertaken in 31 type 2 diabetic patients. For 8 weeks, participants were randomly assigned to a control diet or the DASH eating pattern. Results: After following the DASH eating pattern, body weight (P = 0.007) and waist circumference (P = 0.002) reduced significantly. Fasting blood glucose levels and A1C decreased after adoption of the DASH diet (−29.4 ± 6.3 mg/dl; P = 0.04 and −1.7 ± 0.1%; P = 0.04, respectively). After the DASH diet, the mean change for HDL cholesterol levels was higher (4.3 ± 0.9 mg/dl; P = 0.001) and LDL cholesterol was reduced (−17.2 ± 3.5 mg/dl; P = 0.02). Additionally, DASH had beneficial effects on systolic (−13.6 ± 3.5 vs. −3.1 ± 2.7 mmHg; P = 0.02) and diastolic blood pressure (−9.5 ± 2.6 vs. −0.7 ± 3.3 mmHg; P = 0.04). Conclusions: Among diabetic patients, the DASH diet had beneficial effects on cardiometabolic risks

Dietary factors and biomarkers of systemic inflammation in older people:the Lothian Birth Cohort 1936

Date of Acceptance: 18/05/2015 Acknowledgements The authors thank the LBC1936 participants and study team. They also thank Shirley Jia, Leone Craig and Heather Clark at the University of Aberdeen for performing the FFQ dietary data extraction. The present study was funded by the Age UK’s Disconnected Mind project. The work was undertaken in the University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross-council Lifelong Health and Wellbeing Initiative (MR/K026992/1). The authors gratefully acknowledge the funding from the Biotechnology and Diet and inflammation in later life 1095 British Journal of Nutrition Biological Sciences Research Council and Medical Research Council.Peer reviewedPublisher PD

Effect of fish oil on circulating asymmetric dimethylarginine and adiponectin in overweight or obese patients with atrial fibrillation

Obesity and adipose-derived peptides might be involved in the pathogenesis of atrial fibrillation (AF). Adiponectin plays a major role in the modulation of several metabolic pathways, and asymmetric dimethylarginine (ADMA) has been suggested to be predictive of AF and associated adverse events. The aim of this study was to investigate the effect of fish oil supplementation on circulating adiponectin and ADMA in overweight or obese patients with persistent AF. In this randomized, double-blind, placebo-controlled trial, 80 overweight or obese (body mass index (BMI) � 25 kg/m2) patients with persistent AF were randomly assigned to two groups to receive either 2 g/day fish oil or placebo, for 8 weeks. Serum levels of adiponectin and ADMA, and anthropometric indexes were measured. This study showed that serum adiponectin concentrations increased significantly following fish oil supplementation compared with the placebo group (13.15 ± 7.33 vs. 11.88 ± 6.94 µg/ml; p =.026). A significant reduction was also observed in serum ADMA levels in the fish oil compared with the placebo group following the intervention (0.6 ± 0.13 vs. 0.72 ± 0.15 µmol/L; p =.001). The changes in serum adiponectin and ADMA concentrations remained significant after adjustments for baseline values, age, sex, and changes of BMI and waist circumference (p =.011 and p =.001, respectively). In conclusion, 8 weeks supplementation with fish oil increased serum adiponectin and decreased ADMA concentrations in overweight or obese patients with persistent AF. As adiponectin and ADMA are suggested to be involved in many pathways associated with AF, the current findings might be promising in the clinical management of this disease, an issue that needs further investigations. © 2020 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc

Changing perceptions of hunger on a high nutrient density diet

<p>Abstract</p> <p>Background</p> <p>People overeat because their hunger directs them to consume more calories than they require. The purpose of this study was to analyze the changes in experience and perception of hunger before and after participants shifted from their previous usual diet to a high nutrient density diet.</p> <p>Methods</p> <p>This was a descriptive study conducted with 768 participants primarily living in the United States who had changed their dietary habits from a low micronutrient to a high micronutrient diet. Participants completed a survey rating various dimensions of hunger (physical symptoms, emotional symptoms, and location) when on their previous usual diet versus the high micronutrient density diet. Statistical analysis was conducted using non-parametric tests.</p> <p>Results</p> <p>Highly significant differences were found between the two diets in relation to all physical and emotional symptoms as well as the location of hunger. Hunger was not an unpleasant experience while on the high nutrient density diet, was well tolerated and occurred with less frequency even when meals were skipped. Nearly 80% of respondents reported that their experience of hunger had changed since starting the high nutrient density diet, with 51% reporting a dramatic or complete change in their experience of hunger.</p> <p>Conclusions</p> <p>A high micronutrient density diet mitigates the unpleasant aspects of the experience of hunger even though it is lower in calories. Hunger is one of the major impediments to successful weight loss. Our findings suggest that it is not simply the caloric content, but more importantly, the micronutrient density of a diet that influences the experience of hunger. It appears that a high nutrient density diet, after an initial phase of adjustment during which a person experiences "toxic hunger" due to withdrawal from pro-inflammatory foods, can result in a sustainable eating pattern that leads to weight loss and improved health. A high nutrient density diet provides benefits for long-term health as well as weight loss. Because our findings have important implications in the global effort to control rates of obesity and related chronic diseases, further studies are needed to confirm these preliminary results.</p