Lower lid entropion secondary to treatment with alpha-1a receptor antagonist: a case report

<p>Abstract</p> <p>Introduction</p> <p>The use of alpha-1a receptor antagonists (tamsulosin) is widely accepted in the treatment of benign prostatic hypertrophy (BPH). It has previously been implicated as a causative agent in intra-operative floppy iris syndrome due to its effects on the smooth muscle. We report a case of lower lid entropion that may be related to a patient commencing treatment of tamsulosin.</p> <p>Case presentation</p> <p>A 74-year-old Caucasian man was started on alpha 1-a receptor antagonist (Tamsulosin) treatment for benign prostatic hypertrophy. Eight days later, he presented to the ophthalmology unit with a right lower lid entropion which was successfully treated surgically with a Weiss procedure.</p> <p>Conclusion</p> <p>We report a case of lower lid entropion that may be secondary to the recent use of an alpha-1a blocker (tamsulosin). This can be explained by considering the effect of autonomic blockade on alpha-1 receptors in the Muller's muscle on a patient that may already have an anatomical predisposition to entropion formation due to a further reduction in muscle tone.</p

Survey of epidemiological of parasitic and bacterial infection in cultured fishes of Khouzestan Province

In this study which was carried out in khouzestan province, 1914 Pieces (1160 Pieces silver carp, Hypophthalmychthys molitrix; 498 Pieces common carp, cyprinus carpio; 172 Pieces Grass carp, ctenophryngodon idella and 84 Pieces Big head, Arysthychthys nobilis) from different parts of the province were examined. In three year period, 1378 to 1381, fish samples from four stations were transferred a live to the lab. Water samples also were taken and tested for some of the physicochemical factors. From a total of 1914 fish examined, 1190 showed parasitic infestation and bacterial infections (62.2%). Infestation study, infestation with these parasites have been found: Ichthophthirius, cryptobia, Trichodina, Costia, Hexamita, Dactylogyrus, Gyrodactylus, Lernea, Bothrio cephalus, Diplostomum and Capillaria. Also some species of Aeromonas, staphylococcus, Moraxella, Pectobacterium, Flavobacterium, Citrobacteria, pasteurella, Psedomonas and Alcaligenese were identified in the samples, which normally occur in Water, but in some conditions (High pH, temperature and ammonia) could cause disease and lesions specially in gills. Infestation with dactylogyrus and Gyrodactylus was found in all four kind of fishes with different infestation rate. But the highest infestation rate with dactylogyrus was in silver carp (55.2%) and lowest in common carp (14.6%). The highest infestation rate with gyrodactylus was in grass carp (42.4%) and lowest in common carp (10.6%). Ich, Bothrio cephalus and capillalia were found only in common carp and grass carp. Infestation with adult lernea and copepodid stage of lernea had greater percentage in the gills and derm of grass carp. The data showed infestation with this parasites (especially protozoans and lernea) and bacterial infection had occurred in all seasons especially in C area

Effects of Artemia parthenogenetica culturing on socioeconomic development of the eastern marginal lands, Qom Salt Lake

Saltwater resources with Artemia (Brine shrimp) are the important ecosystems in Semi-arid Areas. That can play an important role in sustaining the economic and social system. Alternatively, will ensure that economic and social issues with of continuity and sustainability of these ecosystems resident. This study carried out "Effects of Artemia parthenogenetica culturing on socio-economic development of the eastern marginal lands, Qom Salt Lake" that was ordered by Qom province general directorate of fisheries during the 2012-2013. According to previous studies, despite the potential of human resources and Social conditions for the development of economic activities, factors such as the low groundwater and drying the salt lake , lack of fresh water in the region, environmental problems , successive droughts, prioritize and rationalize water use in agriculture, Artemia cyst harvest or Artemia culture has made virtually impossible with the current situation and has deprived the tools to make investments for the construction of earthen ponds and exploitation of native Artemia in the eastern margin of the Qom lake . Also, due to the occurrence of the Lake in the national park and privacy protection and Prohibited areas of environmental protection organization, it seems unlikely that this organization grant approval agreement required for any exploitation

The comparative study of the streptococcinum, Hepar sulfur, Rosmarinus officinalis and erythromycin effects on cultured rainbow trout (Oncorhynchus mykiss) with experimental streptococcusis.

The comparative study of the streptococcinum, Hepar sulfur, Rosmarinus officinalis and erythromycin effects on cultured rainbow trout (Oncorhynchus mykiss) with experimental streptococcosis Homeopathy is one of alternative medicines that is very useful for soul and body diseases with accurate prescription. The goal of this study was “survey of the effects of homeopathic remedies. There is not any more research about homeopathy on aquatics in the world especially in Iran, thus Some research about the effects of homeopathy on aquatics is needed. In this study, the effects of streptococcinum, Hepar sulfure, Rosmarinus officinalis(homeopathic remedies) and erythromycin in cultured rainbow trout, with experimental streptococcosis, also the mortality, were compared. There was 6 treatment and 2 reviews in 300 liter tanks that each of treatment contained 40 juvenile rainbow trout with 25±5 gr arrange weight. Treatment 1: contained of erythromycin. Treatment 2: Streptococcinum C30. Treatment 3: Rosmarinus officinalis Q. Treatment 4: Hepar sulfur C30 . Treatment 5:(control treatment )without any injection and any therapy. Treatment 6: (positive control treatment) with injection but without any therapy. Daily estimation of the water temperature, oxygen, pH and salinity and some other chemical factors. Tretment 1 had significance with the other treatments. Survival percent in treatments and their analysis showed that treatment 4(Hep-s) had significance (p<0.05) with treatment 3(Ros-off) and its survival percent is more than the other homeopathic remedies. Erythromycin is chemical drug and has many side effects but Hep-s has not any side effect and is an natural remedy for Streptococcosis in homeopathy. Thus we offer the Hep-s to cure the streptococcosis but some research with disk diffusion test about the different doses of Hep-s is needed. Daily survey of clinical symptoms such as hemorrhages in the external organs, Under eyes, under skin, under fins and gills, hemorrhages and exophthalmos, were the most symptoms. Important pathological symptoms were: necrosis, hyperplasia and melanosis in branches, liver and kidneys, hemorrhages in heart, kidneys and in visceral tissues. According to the survival results, there was significant difference between the treatment 1 and the other treatments (p<0.05). Also there was significant difference between treatment 3, treatment 4 and treatment 2(p<0.05), this difference is due to the high dose(Q) of R.officinalis, while the two other homeopathic remedies were in a moderated dose (C30), 30× 100 diluted dose. Survival percent of treatment 4(Hep-s) was more than the other homeopathic remedies and was related to erythromycin. Erythromycin is chemical medicine and has many side effects, while Hepar sulfur has not any side effects if the prescription would be accurate. Hep-s is suggested with disk diffusion tests for relief the symptoms of streptococcosis

Laboratories risks evaluation of Persian Gulf and Oman Sea Ecological Research Center

In this study, to assess and classify risks associated with working in the laboratories of Persian Gulf and Oman Sea Ecological Research Center, the method of "Failure Mode Effects Analysis" (FMEA) as well as some statistical methods were used. The results of the risk assessment in the 11 affiliated laboratories showed that the risk levels in all cases, except for benthos laboratory, could be evaluated as moderate or high and therefore appropriate corrective actions must be implemented. Based on the results of the Kruskal-Wallis tests both before and after the corrective actions, there were significant differences between the laboratories from the viewpoint of risk priority number (RPN). The post hoc tests showed the lowest risk levels for the benthose and histology laboratories, while the highest risks identified in the laboratory of instrumental analysis. The results of the classification of the laboratories using cluster analysis are largely similar to those of the posthoc tests. According to Mann-Whitney U test, only in the case of the samples preparation laboratory, significant differences between the values of the RPN before and after the corrective actions could be observed (p> 0.05), however, the risk levels still remained high. In general it can be concluded that FMEA is an effective method for risk assessment in the research laboratories and appropriate statistical methods can also be used for complementary analysis

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types