CMS search plans and sensitivity to new physics with dijets

CMS will use dijets to search for physics beyond the standard model during early LHC running. The inclusive jet cross section as a function of jet transverse momentum, with 10 inverse picobarns of integrated luminosity, is sensitive to contact interactions beyond the reach of the Tevatron. The dijet mass distribution will be used to search for dijet resonances coming from new particles, for example an excited quark. Additional sensitivity to the existence of contact interactions or dijet resonances can be obtained by comparing dijet rates in two distinct pseudorapidity regions.Comment: 10 pages, 4 figures, accepted for publication in J. Phys. G: Nucl. Part. Phy

Androgen receptor mutations in prostate cancer

We analyzed the frequency and relevance of mutations in the coding region of the androgen receptor (AR) in genomic DNA extracted from 137 specimens of prostate cancer. The specimens were obtained from the primary tumors of patients affected by stage B disease [15 nonmicrodissected (group 1A) and 84 microdissected (group 1B)] and from the metastatic deposits of individuals with stage D1 disease [8 nonmicrodissected (group 2A) and 30 microdissected (group 2B)] who had not undergone androgen ablation therapy. The study was conducted by PCR-single strand conformational polymorphism (SSCP) analysis of exons 2-8 in the four groups and direct sequence analysis of exon 1 in group 1B. As positive and negative controls, we used genomic DNA extracted from genital skin fibroblasts of patients affected by various forms of androgen resistance with known mutations in the AR. To control for genetic instability, PCR-SSCP analysis of exon 2 of the human progesterone receptor was carried out on each specimen. The overall number of mutations detected was 11 (8%). No mutations were detected in any of the 99 patients with stage B disease. Eleven mutations were detected in exons 2-8 in 8 of the 38 patients with stage D1 disease (all in group 2B). Simultaneous analysis of exon 2 of the progesterone receptor was carried out, and no SSCP changes were identified. These data suggest that AR mutations are rare and presumably do not play a role in the initial phase of prostatic carcinogenesis. The presence of a significant number of AR mutations in metastatic disease indicates that mutations of this molecule may play a role in the most advanced phases of the natural history of this disease, either by facilitating growth or acquisition of the metastatic phenotype

Quantum phase transition in a single-molecule quantum dot

Quantum criticality is the intriguing possibility offered by the laws of quantum mechanics when the wave function of a many-particle physical system is forced to evolve continuously between two distinct, competing ground states. This phenomenon, often related to a zero-temperature magnetic phase transition, can be observed in several strongly correlated materials such as heavy fermion compounds or possibly high-temperature superconductors, and is believed to govern many of their fascinating, yet still unexplained properties. In contrast to these bulk materials with very complex electronic structure, artificial nanoscale devices could offer a new and simpler vista to the comprehension of quantum phase transitions. This long-sought possibility is demonstrated by our work in a fullerene molecular junction, where gate voltage induces a crossing of singlet and triplet spin states at zero magnetic field. Electronic tunneling from metallic contacts into the $\rm{C_{60}}$ quantum dot provides here the necessary many-body correlations to observe a true quantum critical behavior.Comment: 8 pages, 5 figure

Prognostic value of fractional flow reserve: Linking physiologic severity to clinical outcomes

BACKGROUND: Fractional flow reserve (FFR) has become an established tool for guiding treatment, but its graded relationship to clinical outcomes as modulated by medical therapy versus revascularization remains unclear.OBJECTIVES: The study hypothesized that FFR displays a continuous relationship between its numeric value and prognosis, such that lower FFR values confer a higher risk and therefore receive larger absolute benefits from revascularization.METHODS: Meta-analysis of study- and patient-level data investigated prognosis after FFR measurement. An interaction term between FFR and revascularization status allowed for an outcomes-based threshold.RESULTS: A total of 9,173 (study-level) and 6,961 (patient-level) lesions were included with a median follow-up of 16 and 14 months, respectively. Clinical events increased as FFR decreased, and revascularization showed larger net benefit for lower baseline FFR values. Outcomes-derived FFR thresholds generally occurred around the range 0.75 to 0.80, although limited due to confounding by indication. FFR measured immediately after stenting also showed an inverse relationship with prognosis (hazard ratio: 0.86, 95% confidence interval: 0.80 to 0.93; p < 0.001). An FFR-assisted strategy led to revascularization roughly half as often as an anatomy-based strategy, but with 20% fewer adverse events and 10% better angina relief.CONCLUSIONS: FFR demonstrates a continuous and independent relationship with subsequent outcomes, modulated by medical therapy versus revascularization. Lesions with lower FFR values receive larger absolute benefits from revascularization. Measurement of FFR immediately after stenting also shows an inverse gradient of risk, likely from residual diffuse disease. An FFR-guided revascularization strategy significantly reduces events and increases freedom from angina with fewer procedures than an anatomy-based strategy

Observation of Bs0→J/ψf0(980)B_s^0\to J/\psi f_0(980) and Evidence for Bs0→J/ψf0(1370)B_s^0\to J/\psi f_0(1370)

We report the first observation of $B_s^0\to J/\psi f_0(980)$ and first evidence for $B_s^0\to J/\psi f_0(1370)$, which are CP eigenstate decay modes. These results are obtained from $121.4\;\mathrm{fb}^{-1}$ of data collected at the $\Upsilon(5S)$ resonance with the Belle detector at the KEKB $e^+e^-$ collider. We measure the branching fractions $\mathcal{B}(B_s^0\to J/\psi f_0(980);f_0(980)\to\pi^+\pi^-)=(1.16^{+0.31}_{-0.19}(\mathrm{stat.})^{+0.15}_{-0.17}(\mathrm{syst.})^{+0.26}_{-0.18}(N_{B_s^{(*)}\bar B_s^{(*)}})) \times 10^{-4}$ with a significance of $8.4\sigma$, and $\mathcal{B}(B_s^0\to J/\psi f_0(1370);f_0(1370)\to\pi^+\pi^-)=(0.34^{+0.11}_{-0.14}(\mathrm{stat.})^{+0.03}_{-0.02}(\mathrm{syst.})^{+0.08}_{-0.05}(N_{B_s^{(*)}\bar B_s^{(*)}})) \times 10^{-4}$ with a significance of $4.2\sigma$. The last error listed is due to uncertainty in the number of produced $B_s^{(*)}\bar B_s^{(*)}$ pairs.Comment: 5 pages, 2 figures, 2 tables, published in PR