Developing undergraduate projects in multinational teams to enhance employability

Our society is experiencing sudden changes in work organization in part due to the growing ease with which people can collaborate. Many successful cases of peer-to-peer models of organization arise and assume leading positions in world economy replacing, in many cases, the traditional hierarchical organization. People are evolving and interacting within heterogeneous teams composed by members from many different cultural groups and with distinct skills and backgrounds. Modern economy requires engineers to excel in collaborative and communication skills at an international setting. However, these competences are not usually addressed in most engineering curricula. We believe that in such a demanding and culturally diverse environment as the labour market is today, it is essential to promote team work and communication skills at an international and intercultural level. In the Multinational Undergraduate Team Work course, MUTW, students develop their capstone project as members of an international team while working at their home institutions. MUTW projects are to be developed by teams of final-year-undergraduate students from a multinational group of higher education institutions working to solve some engineering problem. Team members are geographically spread to assure heterogeneous teams and to promote international cooperation. This paradigm can be applied in any project/internship course unit. The results from the first edition are very encouraging supporting our initial hypothesis that MUTW significantly promotes students soft skills without requiring any change to prior degree curricula.info:eu-repo/semantics/publishedVersio

Approximate confidence intervals for a linear combination of binomial proportions: A new variant

We propose a new adjustment for constructing an improved version of theWald interval for linear combinations of binomial proportions, which addresses the presence of extremal samples. A comparative simulation study was carried out to investigate the performance of this new variant with respect to the exact coverage probability, expected interval length, and mesial and distal noncoverage probabilities. Additionally, we discuss the application of a criterion for interpreting interval location in the case of small samples and/or in situations in which extremal observations exist. The confidence intervals obtained from the new variant performed better for some evaluation measures

Ensino a distância no Politécnico de Lisboa: necessidades de formação

No contexto da situação pandémica associada à COVID-19, o Politécnico de Lisboa (IPL) criou a Unidade de Ensino a Distância (EaD@IPL), que tem como principal objetivo promover a inovação pedagógica e a competência digital, em permanente sintonia com os avanços da ciência e da tecnologia da comunicação.N/

Characterization of BaTi1-xZrxO3 thin films obtained by a soft chemical spin-coating technique

Single-phase perovskite structure BaZrxTi1-xO3 (BZT) (0.05less than or equal toxless than or equal to0.25) thin films were deposited on Pt-Ti-SiO2-Si substrates by the spin-coating technique. The structural modifications in the thin films were studied using x-ray diffraction and micro-Raman scattering techniques. Lattice parameters calculated from x-ray data indicate an increase in lattice (a axis) with the increasing content of zirconium in these films. Such Zr substitution also result in variations of the phonon mode wave numbers, especially those of lower wave numbers, for BaZrxTi1-xO3 thin films, corroborate to the structural change caused by the zirconium doping. on the other hand, Raman modes persist above structural phase transition, although all optical modes should be Raman inactive in the cubic phase. The origin of these modes must be interpreted as a function of a local breakdown of the cubic symmetry, which could be a result of some kind of disorder. The BZT thin films exhibited a satisfactory dielectric constant close to 181-138, and low dielectric loss tan delta<0.03 at the frequency of 1 kHz. The leakage current density of the BZT thin films was studied at elevated temperatures and the data obey the Schottky emission model. Through this analysis the Schottky barrier height values 0.68, 1.39, and 1.24 eV were estimated to the BZT5, BZT15, and BZT25 thin films, respectively. (C) 2004 American Institute of Physics

Tumor Testing for Somatic and Germline BRCA1/BRCA2 Variants in Ovarian Cancer Patients in the Context of Strong Founder Effects

Deleterious variants in the BRCA1/BRCA2 genes and homologous recombination deficiency (HRD) status are considered strong predictors of response to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi). The introduction of PARPi in clinical practice for the treatment of patients with advanced ovarian cancer imposed changes in the molecular diagnosis of BRCA1/BRCA2 variants. BRCA1/BRCA2 tumor testing by next-generation sequencing (NGS) can detect simultaneously both somatic and germline variants, allowing the identification of more patients with higher likelihood of benefiting from PARPi. Our main goal was to determine the frequency of somatic and germline BRCA1/BRCA2 variants in a series of non-mucinous OC, and to define the best strategy to be implemented in a routine diagnostic setting for the screening of germline/somatic variants in these genes, including the BRCA2 c.156_157insAlu Portuguese founder variant. We observed a frequency of 19.3% of deleterious variants, 13.3% germline, and 5.9% somatic. A higher prevalence of pathogenic variants was observed in patients diagnosed with high-grade serous ovarian cancer (23.2%). Considering the frequencies of the c.3331_3334del and the c.2037delinsCC BRCA1 variants observed in this study (73% of all BRCA1 pathogenic germline variants identified) and the limitations of NGS to detect the BRCA2 c.156_157insAlu variant, it might be cost-effective to test for these founder variants with a specific test prior to tumor screening of the entire coding regions of BRCA1 and BRCA2 by NGS in patients of Portuguese ancestry.PP, JG, MP, and RC were research fellows of the Fundação para a Ciência e a Tecnologia (FCT; UID/DTP/0076/POCI-01-0145-FEDER-006868, SFRH/BD/138670/2018, SFRH/BPD/ 113014/2015, and PB/BD/128001/2016, respectively). AB was a research fellow supported by the project NORTE-01-0145-FEDER-000027, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). CE and RS were research fellows of the Núcleo Regional do Norte da Liga Portuguesa Contra o Cancro