Experimental Constraints on the Neutrino Oscillations and a Simple Model of Three Flavour Mixing

A simple model of the neutrino mixing is considered, which contains only one right-handed neutrino field, coupled via the mass term to the three usual left-handed fields. This is a simplest model that allows for three-flavour neutrino oscillations. The existing experimental limits on the neutrino oscillations are used to obtain constraints on the two free mixing parameters of the model. A specific sum rule relating the oscillation probabilities of different flavours is derived.Comment: 10 pages, 3 figures in post script, Latex, IFT 2/9

Preclinical immunotherapy with Cytokine-Induced Killer lymphocytes against epithelial ovarian cancer

Despite improvements in surgery and medical treatments, epithelial ovarian cancer (EOC) remains the most lethal gynaecological malignancy. Aim of this study is to investigate the preclinical immunotherapy activity of cytokine-induced killer lymphocytes (CIK) against epithelial ovarian cancers, focusing on platinum-resistant settings. We generated CIK ex vivo starting from human peripheral blood samples (PBMCs) collected from EOC patients. Their antitumor activity was tested in vitro and in vivo against platinum-resistant patient-derived ovarian cancer cells (pdOVCs) and a Patient Derived Xenograft (PDX), respectively. CIK were efficiently generated (48 fold median ex vivo expansion) from EOC patients; pdOVCs lines (n = 9) were successfully generated from metastatic ascites; the expression of CIK target molecules by pdOVC confirmed pre and post treatment in vitro with carboplatin. The results indicate that patient-derived CIK effectively killed autologous pdOVCs in vitro. Such intense activity was maintained against a subset of pdOVC that survived in vitro treatment with carboplatin. Moreover, CIK antitumor activity and tumor homing was confirmed in vivo within an EOC PDX model. Our preliminary data suggest that CIK are active in platinum resistant ovarian cancer models and should be therefore further investigated as a new therapeutic option in this extremely challenging setting

A High Statistics Search for Electron-Neutrino --> Tau-Neutrino Oscillations

We present new limits on nu_e to nu_tau and nu_e to nu_sterile oscillations by searching for electron neutrino dissappearance in the high-energy wide-band CCFR neutrino beam. Sensitivity to nu_tau appearance comes from tau decay modes in which a large fraction of the energy deposited is electromagnetic. The beam is composed primarily of muon neutrinos but this analysis uses the 2.3% electron neutrino component of the beam. Electron neutrino energies range from 30 to 600 GeV and flight lengths vary from 0.9 to 1.4 km. This limit improves the sensitivity of existing limits and obtains a lowest 90% confidence upper limit in sin**2(2*alpha) of 9.9 x 10**(-2) at delta-m**2 of 125 eV**2.Comment: submitted to Phys. Rev. D. Rapid Com

Atmospheric neutrino flux from 3-dimensional simulation

The atmospheric muon and neutrino flux have been simulated using the same approach which successfully accounted for the recent secondary proton, electron and positron flux measurements in orbit by the AMS experiment. For the muon flux, a good agreement is obtained with the CAPRICE and HEAT data for altitudes ranging from sea level up to about 38 km. The general features of the calculated atmospheric neutrino flux are reported and discussed. The flux obtained at the Super-Kamiokande experiment location are reported and compared with other calculations. For low neutrino energies the flux obtained is significantly smaller than that used in the data analysis of underground experiment. The simulation results for the SOUDAN experiment site are also reported.Comment: 33 pages, 27 figures, 12 tables, final version for Phys. Rev.

Calcineurin primes immature gonadotropin-releasing hormone-secreting neuroendocrine cells for migration

During development, many neurons display calcium- dependent migration, but the role of this messenger in regulating gene expression leading to this event has not yet been elucidated. Among the decoders of calcium signals is calcineurin, a Ca2 / calmodulin serine/threonine phosphatase that has been involved in both short-term and long-term cellular changes. By using immortalized GnRH-secreting neurons, we now show that, in vitro, Ca2 - dependent gene expression, proceeding via calcineurin and the transcription factor nuclear factor of activated T cells, is a key player controlling the chemomigratory potential of developing GnRH-secreting neurons. Furthermore, our data highlight the switch nature of this phosphatase, whose activation or inactivation guides cells to proceed from one genetic program to the nex

Precision measurement of σ(e+e−→π+π−γ)/σ(e+e−→μ+μ−γ)\sigma(e^+e^-\rightarrow\pi^+\pi^-\gamma)/\sigma(e^+e^-\rightarrow \mu^+\mu^-\gamma) and determination of the π+π−\pi^+\pi^- contribution to the muon anomaly with the KLOE detector

We have measured the ratio $\sigma(e^+e^-\rightarrow\pi^+\pi^-\gamma)/\sigma(e^+e^-\rightarrow \mu^+\mu^-\gamma)$, with the KLOE detector at DA$\Phi$NE for a total integrated luminosity of $\sim$ 240 pb$^{-1}$. From this ratio we obtain the cross section $\sigma(e^+e^-\rightarrow\pi^+\pi^-)$. From the cross section we determine the pion form factor $|F_\pi|^2$ and the two-pion contribution to the muon anomaly $a_\mu$ for $0.592<M_{\pi\pi}<0.975$ GeV, $\Delta^{\pi\pi} a_\mu$= $({\rm 385.1\pm1.1_{stat}\pm2.7_{sys+theo}})\times10^{-10}$. This result confirms the current discrepancy between the Standard Model calculation and the experimental measurement of the muon anomaly.Comment: 18 pages, 8 figures, minor text corrections, one table added, version to appear on Physics Letters