Adverse Drug Reaction Monitoring in Ethiopia: Analysis of case reports, 2002-2007

Background: Ensuring the health and safety of the public from adverse reaction of drugs is paramount. Adverse Drug Reactions Monitoring (ADRM) is a system that is put in place to ensure the health and safety of the public from adverse reactions of drugs. It heavily relies on health professionals (HPs) reporting of adverse events of drugs to drug regulators, in Ethiopia to the Drug Administration and Control Authority (DACA). The processed information, based on reported cases, is used to improve evidence based practice and underpins decisions to mitigate drug safety issues by drug regulators. However, the effectiveness of the ongoing ADRM system in Ethiopia in terms of its detection has never been evaluated.Objective: To explore the magnitude of ADRM and suggest some practical improvement in Ethiopia.Methods: The study analyzed the number of adverse drug reaction case reports received by DACA in a period of six years (2002 – 2007GC). All cases reported over the study period were included for analysis. Descriptive analysis was carried out to estimate the prevalence of adverse drug reactions and to assess their trend over the study period. To assess the strengths and weakness of the ongoing national ADRM, cases were analyzed by their location, time of occurrence, type of the health professional who made the case reports, drugs implicated, clinical manifestations and age of subjects affected.Results: A total of 249 ADR cases were reported between 2002 and 2007. An average of 0.5 ADR cases per million populations were reported annually. The majority (36%) of all the cases were for 31 to 40 years of age. Cases were reported mainly (63%) from health facilities in the capital city. Physicians made 76% of all cases reported. Antiretroviral drugs were implicated in 70% of the cases reported. The most widely adverse events reported were dermatological disorders.Conclusions: The level of ADR case reporting is very low showing the need to address major constraints of ongoing ADR monitoring. Thus, comprehensive measures aimed at improving under-reporting and effectiveness of ADRM should be instituted. [Ethiop. J. Health Dev. 2011;25(2):168-173

Squalene and amentoflavone from Antidesma laciniatum

Squalene, (2E, 7x,11x)-phyt-2-en-1-ol and amentoflavone have been isolated from the extract of the leaves of Antidesma laciniatum. Their structures were elucidated using spectroscopic methods. This is the first report of these compounds from Antidesma species.   KEY WORDS: Antidesma laciniatum, Euphorbiaceae, Squalene, Amentoflavone, (2E, 7x,11x)-Phyt-2-en-1-ol  Bull. Chem. Soc. Ethiop. 2006, 20(2), 325-328

Rate and predictors of neonatal jaundice in northwest Ethiopia : prospective cohort study

Background: Neonatal jaundice is one of the most common clinical disorders occurred worldwide. About 1.1 million neonates develop jaundice per year globally and the vast majority of them found in sub-Saharan Africa and South Asia. There is a paucity of evidence on the incidence rate and predictors of neonatal jaundice in Ethiopia. Therefore, this study was aimed at determining the rate and predictors of neonatal jaundice in the northwest, Ethiopia. Methods: A prospective cohort study design was conducted at Debre Markos comprehensive, specialized Hospitals using 334 neonates from October 1, 2019, to June 30, 2020. Using a systematic random sampling technique, the study subjects were drawn. Data were entered into the Epi-DataTM Version 4.2 and analyzed using STATATM Version 14.0. The Kaplan-Meier survival curve was used to estimate the survival time. A generalized Log rank test was used to compare the survival curves of different categorical variables. Finally, both bi-variable and multivariable Cox-proportional hazards regression models were used to identify the predictors of neonatal jaundice. The Results: The overall incidence rate of jaundice among neonates was 4.5 per 100 person-hours. Long duration of labor [ARR = 3.5; 95% confidence interval (CI), (2.8– 8.7)], being male neonates [ARR= 5.2; 95% CI (3.5–7.3)], “O” blood group mothers [ARR = 4.5; 95% CI (3.4–10.3)], and having neonatal sepsis 3.4 [ARR=3.4; 95% CI: (2.5–6.1)] were predictors. Conclusion: The incidence rate of jaundice was higher in this study than the finding of the previous one. Being male, prolonged duration of labor, “O” blood group mothers and sepsis were the significant predictors. Hence, an effort has to be made to decrease the incidence rate of neonatal jaundice through improving newborn care and timely intervention for neonates with sepsis and delivered at a long duration of time as well as the neonates born from “o” blood type mothers are our recommendation

Chronic Wasting Disease and Potential Transmission to Humans

Chronic wasting disease (CWD) of deer and elk is endemic in a tri-corner area of Colorado, Wyoming, and Nebraska, and new foci of CWD have been detected in other parts of the United States. Although detection in some areas may be related to increased surveillance, introduction of CWD due to translocation or natural migration of animals may account for some new foci of infection. Increasing spread of CWD has raised concerns about the potential for increasing human exposure to the CWD agent. The foodborne transmission of bovine spongiform encephalopathy to humans indicates that the species barrier may not completely protect humans from animal prion diseases. Conversion of human prion protein by CWD-associated prions has been demonstrated in an in vitro cell-free experiment, but limited investigations have not identified strong evidence for CWD transmission to humans. More epidemiologic and laboratory studies are needed to monitor the possibility of such transmissions

Review of Methodologies for Land Degradation Neutrality Baselines: Sub-National case studies from Costa Rica and Namibia

The objective of this report is to identify entry points and challenges for subnational LDN baselines in order to inform subnational planning processes as potential vehicle for the implementation of LDN targets on the ground. For this purpose two focus regions were chosen within two of the countries – namely Namibia and Costa Rica – that participated in the first LDN pilot phase. The focus areas in Namibia and Costa Rica are the regions of Otjozondjupa and Rio Jesus Maria watershed respectively. Both Namibia and Costa Rica provide interesting case studies given the differences in types of land degradation, national capacities, and land resources

Screening of ethyl methane sulphonate mutagenized tef [ Eragrostis tef (Zucc.) Trotter] population identifies Al-tolerant lines

About 15,000 M2 seeds of ethyl-methane-sulphonate (EMS)-mutagenized population were screened along with Al-tolerant and sensitive checks and the M0 variety. Strongly acidic soil with an external application of a toxic Al-solution and exposure to moisture stress was used to maximize selection pressure. Twenty-one M2 plants with root lengths of greater than the mean of the tolerant check were selected and planted for seed production. Candidate M3 plants were investigated for Al-tolerance and for morpho-agronomic traits under greenhouse and field conditions, respectively. Highly significant differences were observed for Al-tolerance between the candidate mutant lines and the M0 (P < .001), and between mutant lines and the sensitive check (P < .001). Similarly, significant differences were observed between the mutant lines for 16 of the 20 quantitative traits measured. This study is the first to report successful induction of enhanced Al-tolerance in tef by using EMS mutagenized population

National Trends in Cessation Counseling, Prescription Medication Use, and Associated Costs Among US Adult Cigarette Smokers

Importance: Cigarette smoking is the leading cause of preventable disease and death in the United States. When used separately or in combination, smoking cessation counseling and cessation medications have been associated with increased cessation rates. Objectives: To present trends in self-reported receipt of physician advice to quit smoking and in use of prescription smoking cessation medication along with their associated expenditures among a nationally representative sample of active adult smokers in the United States. Design, Setting, and Participants: This repeated cross-sectional study of US adults aged 18 years or older was conducted from July 5, 2018, through August 15, 2018. Data were collected between January 1, 2006, and December 31, 2015, from the Medical Expenditure Panel Survey, an annual US survey of individuals and families, health care personnel, and employers. Participants (n = 29 106) were noninstitutionalized civilians who were randomly drawn from the respondents of the previous year’s National Health Interview Survey. Multivariable logistic regression models were used to examine the associations between sociodemographic factors and receipt of physician cessation advice and use of cessation prescription medication. A 2-part econometric model was used to assess health care expenditures. Main Outcomes and Measures: Trends in self-reported receipt of physician advice to quit and uptake of prescription smoking cessation medications with associated total and out-of-pocket expenditures. Results: The study sample consisted of 29 106 participants, with a mean (SD) age of 57 (10) years and a composition of 13 670 women (47.0%). The results were weighted to provide estimates for 31.2 million active adult cigarette smokers. The proportion of smokers who reported receiving physician advice to quit increased from 60.2% (95% CI, 58.5%-62.0%) in 2006 to 2007 to 64.9% (95% CI, 62.8%-66.9%) in 2014 to 2015, with a P for trend = .001. The odds of receiving physician cessation advice was statistically significantly higher in women (odds ratio [OR], 1.50; 95% CI, 1.39-1.59) and lower among uninsured participants (OR, 0.58; 95% CI, 0.52-0.65). Overall, prescription smoking cessation medication use decreased with a corresponding reduction in total expenditures from $146 million (out-of-pocket cost,$46 million) in 2006 to 2007 to $73 million (out-of-pocket cost,$9 million) in 2014 to 2015. Male (odds ratio [OR], 0.78; 95% CI, 0.66-0.91), uninsured (OR, 0.58; 95% CI, 0.41-0.83), and racial/ethnic minority (African American: OR, 0.51 [95% CI, 0.38-0.69]; Asian: OR, 0.31 [95% CI, 0.10-0.93]; Hispanic: OR, 0.53 [95% CI, 0.36-0.78]) participants were less likely to use prescription smoking cessation medications. Conclusions and Relevance: The lower rates of delivery of physician advice to quit smoking and the lower uptake of known prescription smoking cessation medications among men, younger adults, uninsured individuals, racial/ethnic minority groups, and those without smoking-associated comorbidities may be associated with the higher smoking rates among these subgroups despite an all-time low prevalence of smoking in the United States; this finding calls for a more targeted implementation of smoking cessation guidelines

Including soil organic carbon into nationally determined contributions: Insights from Senegal

Healthy soils are the foundation of sustainable and regenerative food systems and provide several vital ecosystem services Sequestering carbon in agricultural soils, for example, can have mutual benefits for climate change mitigation and adaptation, food and nutrition security, biodiversity, and water resilience. Despite these benefits, there are few policies that incentivize farmers to invest in maintaining and improving soil health. This policy brief highlights opportunities for the inclusion of soil health and soil organic carbon (SOC) into the National Determined Contributions (NDC) as a key step for governments to support farmers to invest in their soil. We interviewed key informants involved in the NDC process to understand the process for the developing the NDC targets and investigated reasons why policy makers did or did not include soil in these targets