Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway

Mice lacking all three Rb genes in the liver develop tumors resembling specific subgroups of human hepatocellular carcinomas, and Notch activity appears to suppress the growth and progression of these tumors

Identification of GBV-D, a Novel GB-like Flavivirus from Old World Frugivorous Bats (Pteropus giganteus) in Bangladesh

Bats are reservoirs for a wide range of zoonotic agents including lyssa-, henipah-, SARS-like corona-, Marburg-, Ebola-, and astroviruses. In an effort to survey for the presence of other infectious agents, known and unknown, we screened sera from 16 Pteropus giganteus bats from Faridpur, Bangladesh, using high-throughput pyrosequencing. Sequence analyses indicated the presence of a previously undescribed virus that has approximately 50% identity at the amino acid level to GB virus A and C (GBV-A and -C). Viral nucleic acid was present in 5 of 98 sera (5%) from a single colony of free-ranging bats. Infection was not associated with evidence of hepatitis or hepatic dysfunction. Phylogenetic analysis indicates that this first GBV-like flavivirus reported in bats constitutes a distinct species within the Flaviviridae family and is ancestral to the GBV-A and -C virus clades

Phage Lambda P Protein: Trans-Activation, Inhibition Phenotypes and their Suppression

viruse

Massive Saddle Pulmonary Embolism in a Preterm Neonate With Successful Emergent Open EmbolectomyNovel Teaching Points

Pulmonary embolism in the neonate is a rare, life-threatening emergency. Risk factors for neonatal pulmonary embolism (PE) include sepsis, asphyxia, prematurity, and vascular catheterisation. We report the case of a preterm neonate with a massive saddle pulmonary thrombosis of unidentified etiology. Prompt diagnosis by cardiology allowed an emergent lifesaving open surgical thrombectomy, underscoring the importance of efficient multidisciplinary teamwork. Pediatric health-care professionals must be aware of this rare entity when initial oxygen desaturation management fails, even when obvious risk factors for PE are not apparent. We emphasise the importance of seamless multidisciplinary communication and proactive surgical consultation. Résumé: L’embolie pulmonaire chez le nouveau-né est une urgence rare qui met la vie en danger. Les facteurs de risque d’embolie pulmonaire néonatale comprennent la septicémie, l’asphyxie, la prématurité et le cathétérisme vasculaire. Nous rapportons le cas d’un nouveau-né prématuré présentant une thrombose pulmonaire en selle massive d’origine indéterminée. Un diagnostic rapide par le service de cardiologie a permis la réalisation d’urgence d’une thrombectomie chi-rurgicale ouverte salvatrice, soulignant ainsi l’importance d’un travail d’équipe multidisciplinaire efficace. Les professionnels de la santé en pédiatrie doivent être au fait de cette entité rare lorsque la prise en charge initiale de la désaturation en oxygène échoue, même quand les facteurs de risque évidents d'une embolie pulmonaire ne sont pas apparents. Nous insistons sur l’importance d’une communication multidisciplinaire en continu et d’une consultation chirurgicale proactive

Embryonal tumor with multilayered rosettes: Overview of diagnosis and therapy

Acknowledgements: This research was made possible through access to the data and findings generated by the 100 000 Genomes Project. The 100 000 Genomes Project is managed by Genomics England Limited (a wholly owned company of the Department of Health and Social Care). The 100 000 Genomes Project is funded by the National Institute for Health Research and NHS England. The Wellcome Trust, Cancer Research UK, and the Medical Research Council have also funded research infrastructure. The 100 000 Genomes Project uses data provided by patients and collected by the National Health Service as part of their care and support. TSJ is grateful for funding from Great Ormond Street Children’s Charity, The Brain Tumour Charity, Children with Cancer UK, Cancer Research UK, NIHR and the Olivia Hodson Cancer Fund. All research at GOSH NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR GOSH Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health

Embryonal tumor with multilayered rosettes: Overview of diagnosis and therapy

Acknowledgements: This research was made possible through access to the data and findings generated by the 100 000 Genomes Project. The 100 000 Genomes Project is managed by Genomics England Limited (a wholly owned company of the Department of Health and Social Care). The 100 000 Genomes Project is funded by the National Institute for Health Research and NHS England. The Wellcome Trust, Cancer Research UK, and the Medical Research Council have also funded research infrastructure. The 100 000 Genomes Project uses data provided by patients and collected by the National Health Service as part of their care and support. TSJ is grateful for funding from Great Ormond Street Children’s Charity, The Brain Tumour Charity, Children with Cancer UK, Cancer Research UK, NIHR and the Olivia Hodson Cancer Fund. All research at GOSH NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR GOSH Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health

Embryonal tumor with multilayered rosettes: Overview of diagnosis and therapy

Acknowledgements: This research was made possible through access to the data and findings generated by the 100 000 Genomes Project. The 100 000 Genomes Project is managed by Genomics England Limited (a wholly owned company of the Department of Health and Social Care). The 100 000 Genomes Project is funded by the National Institute for Health Research and NHS England. The Wellcome Trust, Cancer Research UK, and the Medical Research Council have also funded research infrastructure. The 100 000 Genomes Project uses data provided by patients and collected by the National Health Service as part of their care and support. TSJ is grateful for funding from Great Ormond Street Children’s Charity, The Brain Tumour Charity, Children with Cancer UK, Cancer Research UK, NIHR and the Olivia Hodson Cancer Fund. All research at GOSH NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR GOSH Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health