Relationships of Scores Achieved on a Crawl Stroke Rating Form and Selected Measures of Stroke Efficiency in Swimming

The continuous surpassing of records is an indication that performances in competitive swimming are steadily improving. Success in competition depends upon a swimmer’s ability to “maintain a high velocity over time.” Factors which determine the ability to maintain high velocity include muscle endurance, efficiency, and total capacity for energy expenditure. Though various training methods, the swim coach has been able to increase physiological change in his athletes, including muscular endurance. A valid measure for determining energy expenditure is through analysis of data obtained by testing for oxygen consumption. There is also a linear relationship between oxygen consumption and heart rate. By observing heart rates, the energy expended could be determined by similar procedures. However, measures of determining stroke efficiency are either time consuming or confined to laboratory equipment. The swim coach should have a measuring tool that could be used to determine efficiency of the swimmer available to poolside without being time consuming or limited to laboratory equipment. Therefore a comparative analysis of selected measures of determining stroke efficiency to crawl stroke form rating scale was deemed necessary by the investigator

PESSCARA: An Example Infrastructure for Big Data Research

Big data requires a flexible system for data management and curation which has to be intuitive, and it should also be able to execute non-linear analysis pipelines suitable to handle with the nature of big data. This is certainly true for medical images where the amount of data grows exponentially every year and the nature of images rapidly changes with technological advances and rapid genomic advances. In this chapter, we describe a system that provides flexible management for medical images plus a wide array of associated metadata, including clinical data, genomic data, and clinical trial information. The system consists of open-source Content Management System (CMS) that has a highly configurable workflow; has a single interface that can store, manage, enable curation, and retrieve imaging-based studies; and can handle the requirement for data auditing and project management. Furthermore, the system can be extended to interact with all the modern big data analysis technologies

Effect of Urea and Distillers Inclusion in Dry- Rolled Corn Based Diets on Heifer Performance and Carcass Characteristics

Crossbred heifers (n=96, BW = 810 ± 20) were utilized to evaluate the effects of increasing wet distillers grains plus solubles and urea inclusion in a dry rolled corn based finishing diet on performance and carcass characteristics. Heifers were individually fed using a calan gate system with a 2 × 2 factorial arrangement of treatments. Factors included distillers inclusion at either 10 or 20% of diet DM and urea inclusion at either 0.2 or 1.4% of diet DM. Th ere was no difference for final body weight, average daily gain, and feed conversion on a live or carcass adjusted basis for either urea or distillers inclusion in the diet. Dry matter intake was reduced with increased urea inclusion; however, distillers inclusion did not influence intake. Added distillers and urea in the diet had minimal impact on performance suggesting supplemental urea in a dry rolled corn based finishing diets is of minimal benefit when feeding at least 10% distillers grains

Evaluation of Masters Choice Corn Silage on Growing Steer Performance

A growing study evaluated three corn silage hybrids on growing steer performance. Th e three hybrids were: a conventional hybrid- Farm Choice (CON) commonly grown in Eastern Nebraska which served as the control, Masters Choice hybrids MCT6365 RIB (MC1) selected to improve fi ber and starch digestion and MCT6733 GT3000 (MC2) that has been selected to improve fi ber digestion in cattle. Relative to CON, feeding hybrid MC1 resulted in similar DMI, but numerically increased ADG which significantly improved F:G compared to CON. Feeding MC2 led to greater DMI, similar ADG, and poorer (greater) F:G compared to CON. Feeding Masters Choice hybrid MCT6365 RIB (MC1) corn silage at 80% of the diet DM likely improved digestion and energy availability to the steers, which allowed greater ADG and improved F:G, while the opposite was true for MC2. Differences in hybrids exist when fed to growing cattle at 80% of the diet

COSMOLOGICAL NARRATIVE IN THE SYNAGOGUES OF LATE ROMAN-BYZANTINE PALESTINE

The night sky provided ancient peoples with a visible framework through which they could view and experience the divine. Ancient astronomers looked to the night sky for practical reasons, such as the construction of calendars by which time could evenly be divided, and for prognosis, such as the foretelling of future events based on the movements of the planets and stars. While scholars have written much about the Greco-Roman understanding of the night sky, few studies exist that examine Jewish cosmological thought in relation to the appearance of the Late Roman-Byzantine synagogue Helios-zodiac cycle. This dissertation surveys the ways that ancient Jews experienced the night sky, including literature of the Second Temple (sixth century BCE – 70 CE), rabbinic and mystical writings, and Helios-zodiac cycles in synagogues of ancient Palestine. I argue that Judaism joined an evolving Greco-Roman cosmology with ancient Jewish traditions as a means of producing knowledge of the earthly and heavenly realms.Doctor of Philosoph

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist

Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the controversy regarding the pharmacological action of nebivolol. Carvedilol is another β-blocker that induces NO production. A prominent pharmacological mechanism of carvedilol is biased agonism that is independent of Gαs and involves G protein-coupled receptor kinase (GRK)/β-arrestin signaling with downstream activation of the epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase (ERK). Due to the pharmacological similarities between nebivolol and carvedilol, we hypothesized that nebivolol is also a GRK/β-arrestin biased agonist. We tested this hypothesis utilizing mouse embryonic fibroblasts (MEFs) that solely express β2-ARs, and HL-1 cardiac myocytes that express β1- and β2-ARs and no detectable β3-ARs. We confirmed previous reports that nebivolol does not significantly alter cAMP levels and thus is not a classical agonist. Moreover, in both cell types, nebivolol induced rapid internalization of β-ARs indicating that nebivolol is also not a classical β-blocker. Furthermore, nebivolol treatment resulted in a time-dependent phosphorylation of ERK that was indistinguishable from carvedilol and similar in duration, but not amplitude, to isoproterenol. Nebivolol-mediated phosphorylation of ERK was sensitive to propranolol (non-selective β-AR-blocker), AG1478 (EGFR inhibitor), indicating that the signaling emanates from β-ARs and involves the EGFR. Furthermore, in MEFs, nebivolol-mediated phosphorylation of ERK was sensitive to pharmacological inhibition of GRK2 as well as siRNA knockdown of β-arrestin 1/2. Additionally, nebivolol induced redistribution of β-arrestin 2 from a diffuse staining pattern into more intense punctate spots. We conclude that nebivolol is a β2-AR, and likely β1-AR, GRK/β-arrestin biased agonist, which suggests that some of the unique clinically beneficial effects of nebivolol may be due to biased agonism at β1- and/or β2-ARs. © 2013 Erickson et al