Innovative technologies of extruded foods with alcoprotective action on the basis of fish raw

У статті наведений аналіз динаміки споживчих вподобань екструдованої снекової продукції на основі рибної сировини та обгрунтована доцільність створення харчових композицій з крупок зернових та картопляних пластівців, збагачених рибними порошками, з регулюємим хімічним складом та біологічною цінністю. З точки зору хімічних та біохімічних процесів описано властивості гліцину та бурштинової кислоти, як речовин, що нейтралізують токсичну дію ацетальдегіду в організмі людини під час вживання слабоалкогольних напоїв. Обгрунтована перспективність виробництва екструдованої продукції з компонентами, що перешкоджають руйнуванню клітин печінки та мозку у разі споживання слабоалкогольних напоїв. Проведена органолептична оцінка розроблених екструдованих продуктів, за результатами якої обгрунтована перспективність використання рибних порошків для виробництва екструдованих продуктів.The article analyzes the dynamics of consumer preferences of extruded snack foods on the basis of fish raw materials and substantiates the expediency of creating food compositions from grains of cereals and potato flakes enriched with fish powders, with regulated chemical composition and biological value. From the point of view of chemical and biochemical processes, the properties of glycine and amber acid are described as substances that neutralize the toxic effect of acetaldehyde in the human body during the use of low-alcohol beverages. The prospect of production of extruded products with components that prevent the destruction of liver and brain cells in the case of low-alcohol beverages is substantiated. The organoleptic evaluation of extruded products developed, the results of which proved the prospect of using fish powders for the production of extruded products. In the given work the technology of innovative food product - with functional alkoprotektornymi properties was presented. It is assumed that this product will expand the range of snack snacks to low-alcohol beverages and will be a reliable protection against the harmful effects of alcohol and its metabolism products in the human bod

Multiply-connected Bose-Einstein condensed alkali gases: Current-carrying states and their decay

The ability to support metastable current-carrying states in multiply-connected settings is one of the prime signatures of superfluidity. Such states are investigated theoretically for the case of trapped Bose condensed alkali gases, particularly with regard to the rate at which they decay via thermal fluctuations. The lifetimes of metastable currents can be either longer or shorter than experimental time-scales. A scheme for the experimental detection of metastable states is sketched.Comment: 4 pages, including 1 figure (REVTEX

Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation

PICH (Plk1-interacting checkpoint helicase) was recently identified as an essential component of the spindle assembly checkpoint and shown to localize to kinetochores, inner centromeres, and thin threads connecting separating chromosomes even during anaphase. In this paper, we have used immuno-fiber fluorescence in situ hybridization and chromatin-immunoprecipitation to demonstrate that PICH associates with centromeric chromatin during anaphase. Furthermore, by careful analysis of PICH-positive anaphase threads through FISH as well as bromo-deoxyurdine and CREST labeling, we strengthen the evidence that these threads comprise mainly alphoid centromere deoxyribonucleic acid. Finally, by timing the addition of ICRF-193 (a specific inhibitor of topoisomerase-II alpha) to cells synchronized in anaphase, we demonstrate that topoisomerase activity is required specifically to resolve PICH-positive threads during anaphase (as opposed to being required to prevent the formation of such threads during earlier cell cycle stages). These data indicate that PICH associates with centromeres during anaphase and that most PICH-positive threads evolve from inner centromeres as these stretch in response to tension. Moreover, they show that topoisomerase activity is required during anaphase for the resolution of PICH-positive threads, implying that the complete separation of sister chromatids occurs later than previously assumed

Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?

The INSIG2 rs7566605 polymorphism was identified for obesity (BMI≥30 kg/m2) in one of the first genome-wide association studies, but replications were inconsistent. We collected statistics from 34 studies (n = 74,345), including general population (GP) studies, population-based studies with subjects selected for conditions related to a better health status (‘healthy population’, HP), and obesity studies (OB). We tested five hypotheses to explore potential sources of heterogeneity. The meta-analysis of 27 studies on Caucasian adults (n = 66,213) combining the different study designs did not support overall association of the CC-genotype with obesity, yielding an odds ratio (OR) of 1.05 (p-value = 0.27). The I2 measure of 41% (p-value = 0.015) indicated between-study heterogeneity. Restricting to GP studies resulted in a declined I2 measure of 11% (p-value = 0.33) and an OR of 1.10 (p-value = 0.015). Regarding the five hypotheses, our data showed (a) some difference between GP and HP studies (p-value = 0.012) and (b) an association in extreme comparisons (BMI≥32.5, 35.0, 37.5, 40.0 kg/m2 versus BMI<25 kg/m2) yielding ORs of 1.16, 1.18, 1.22, or 1.27 (p-values 0.001 to 0.003), which was also underscored by significantly increased CC-genotype frequencies across BMI categories (10.4% to 12.5%, p-value for trend = 0.0002). We did not find evidence for differential ORs (c) among studies with higher than average obesity prevalence compared to lower, (d) among studies with BMI assessment after the year 2000 compared to those before, or (e) among studies from older populations compared to younger. Analysis of non-Caucasian adults (n = 4889) or children (n = 3243) yielded ORs of 1.01 (p-value = 0.94) or 1.15 (p-value = 0.22), respectively. There was no evidence for overall association of the rs7566605 polymorphism with obesity. Our data suggested an association with extreme degrees of obesity, and consequently heterogeneous effects from different study designs may mask an underlying association when unaccounted for. The importance of study design might be under-recognized in gene discovery and association replication so far