Effects of implementing school-wide positive behavioral intervention and supports in an alternative school setting

One correctional alternative to punitive consequences is School Wide Positive Behavioral Intervention and Supports. The program’s effects on behavior, achievement, and social behavior of students in a juvenile corrections facility were examined. There was a significant difference in the number of problem behavioral referrals between the pre (n = 130, M = 4.28) and post periods (n = 98, M = 3.23, p =.05, d=.27, small effect size). Themes from a focus group of school personnel (N=6): an improvement of classroom management skills by teachers, inconsistent application of positive behavioral supports, and a lack of administration support for the program

“It didn’t matter what the bill said...”: Influences on abortion policy legislative decision-making in Georgia

Background: In March 2019 the Georgia legislature passed HB 481 described as a “heartbeat bill”, prohibiting abortion at around six weeks gestation. Given the prevalence of anti-abortion legislation and the public health implications of abortion restrictions, we sought to understand how Georgia legislators made decisions on this early abortion ban legislation. Methods: We conducted in-depth interviews with nine legislators from the Georgia House of Representatives who participated in the 2019 legislative session. In-depth interviews were conducted in-person and over the phone. Interview recordings were transcribed verbatim and inductive codes identified. Codes focused primarily on views of: abortion in general; specific abortion policy; and how information about HB 481 was obtained. A thematic analysis was performed to elucidate legislators’ perspectives. Results: Legislators had clear considerations that differed by party affiliation. Democrats described concerns with HB 481 grounded in reproductive autonomy and justice. They claimed concern with the lives of pregnant persons citing the physical and emotional harm bills like HB 481 cause. They questioned the medical evidence used to support HB 481 and argued that it violated the freedom to choose when to have children. Republican legislators evoked a similar harm reduction framework, but were concerned with protecting the lives of the unborn, arguing that a fetus should be considered a person once a “heartbeat” is detected and that abortion after this point is equal to killing a person. Republicans also described aligning with their constituents’ values. Despite the arguments and evidence presented during the legislative session, legislators voted according to their previously held beliefs on abortion. Conclusions: Controversial abortion legislation is commonplace, bringing with it heated debates on when life begins and how to protect it. It is important to understand the underlying motives for legislators’ decisions to enhance communication and improve policy outcomes related to reproductive health and rights

“This Little Patch of Earth is Inexhaustible”: Ernst Ludwig Kirchner and the Outdoors Movements

This thesis focuses on the influence of reform movements and hiking and mountaineering organizations on the life and work of Ernst Ludwig Kirchner. I explore how principles of these outdoors movements, including a healthy mind/body connection and rustic lifestyle, inform Kirchner’s works created while living in Davos, Switzerland

Understanding the management of doctoral studies in Australia as risk management

This paper discusses and analyses theoretical explanations of risk and risk management in terms of the management of doctoral studies. It deals with the ways in which Government policy, together with contemporary approaches to the bureaucratisation of risk management and the development and imposition of rationalities of risk, are shaping the practices of universities concerning the selection, supervision, support and assessment of doctoral candidates. In particular, the impact of the Research Training Scheme on doctoral studies is discussed as a particular context in which the institutionalisation of risk management occurs.<br /

Range-Based Equal Error Rate for Spoof Localization

Spoof localization, also called segment-level detection, is a crucial task that aims to locate spoofs in partially spoofed audio. The equal error rate (EER) is widely used to measure performance for such biometric scenarios. Although EER is the only threshold-free metric, it is usually calculated in a point-based way that uses scores and references with a pre-defined temporal resolution and counts the number of misclassified segments. Such point-based measurement overly relies on this resolution and may not accurately measure misclassified ranges. To properly measure misclassified ranges and better evaluate spoof localization performance, we upgrade point-based EER to range-based EER. Then, we adapt the binary search algorithm for calculating range-based EER and compare it with the classical point-based EER. Our analyses suggest utilizing either range-based EER, or point-based EER with a proper temporal resolution can fairly and properly evaluate the performance of spoof localization.Comment: Accepted to Interspeech 202

Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization

AbstractInterleukin 2-inducible T cell kinase (ITK) influences T cell signaling by coordinating actin polymerization and polarization as well as recruitment of kinases and adapter proteins. ITK regulates multiple steps of HIV-1 replication, including virion assembly and release. Fluorescent microscopy was used to examine the functional interactions between ITK and HIV-1 Gag during viral particle release. ITK and Gag colocalized at the plasma membrane and were concentrated at sites of F-actin accumulation and membrane lipid rafts in HIV-1 infected T cells. There was polarized staining of ITK, Gag, and actin towards sites of T cell conjugates. Small molecule inhibitors of ITK disrupted F-actin capping, perturbed Gag-ITK colocalization, inhibited virus like particle release, and reduced HIV replication in primary human CD4+ T cells. These data provide insight as to how ITK influences HIV-1 replication and suggest that targeting host factors that regulate HIV-1 egress provides an innovative strategy for controlling HIV infection

Wee1-Regulated Apoptosis Mediated by the Crk Adaptor Protein in Xenopus Egg Extracts

Many of the biochemical reactions of apoptotic cell death, including mitochondrial cytochrome c release and caspase activation, can be reconstituted in cell-free extracts derived from Xenopus eggs. In addition, because caspase activation does not occur until the egg extract has been incubated for several hours on the bench, upstream signaling processes occurring before full apoptosis are rendered accessible to biochemical manipulation. We reported previously that the adaptor protein Crk is required for apoptotic signaling in egg extracts (Evans, E.K., W. Lu, S.L. Strum, B.J. Mayer, and S. Kornbluth. 1997. EMBO (Eur. Mol. Biol. Organ.) J. 16:230–241). Moreover, we demonstrated that removal of Crk Src homology (SH)2 or SH3 interactors from the extracts prevented apoptosis. We now report the finding that the relevant Crk SH2-interacting protein, important for apoptotic signaling in the extract, is the well-known cell cycle regulator, Wee1. We have demonstrated a specific interaction between tyrosine-phosphorylated Wee1 and the Crk SH2 domain and have shown that recombinant Wee1 can restore apoptosis to an extract depleted of SH2 interactors. Moreover, exogenous Wee1 accelerated apoptosis in egg extracts, and this acceleration was largely dependent on the presence of endogenous Crk protein. As other Cdk inhibitors, such as roscovitine and Myt1, did not act like Wee1 to accelerate apoptosis, we propose that Wee1–Crk complexes signal in a novel apoptotic pathway, which may be unrelated to Wee1's role as a cell cycle regulator