3,264 research outputs found
Prediction of disease outcome in an acute lung infection in pigs: promising role for IL-Ââ6?
Limitations of the Standard Gravitational Perfect Fluid Paradigm
We show that the standard perfect fluid paradigm is not necessarily a valid
description of a curved space steady state gravitational source. Simply by
virtue of not being flat, curved space geometries have to possess intrinsic
length scales, and such length scales can affect the fluid structure. For modes
of wavelength of order or greater than such scales eikonalized geometrical
optics cannot apply and rays are not geodesic. Covariantizing thus entails not
only the replacing of flat space functions by covariant ones, but also the
introduction of intrinsic scales that were absent in flat space. In principle
it is thus unreliable to construct the curved space energy-momentum tensor as
the covariant generalization of a geodesic-based flat spacetime energy-momentum
tensor. By constructing the partition function as an incoherent average over a
complete set of modes of a scalar field propagating in a curved space
background, we show that for the specific case of a static, spherically
symmetric geometry, the steady state energy-momentum tensor that ensues will in
general be of the form
where the
anisotropic is a symmetric, traceless rank two tensor which
obeys . Such a type term is absent for an
incoherently averaged steady state fluid in a spacetime where there are no
intrinsic length scales, and in principle would thus be missed in a
covariantizing of a flat spacetime . While the significance of such
type terms would need to be evaluated on a case by case basis,
through the use of kinetic theory we reassuringly find that the effect of such
type terms is small for weak gravity stars where perfect fluid
sources are commonly used.Comment: Final version to appear in General Relativity and Gravitation (the
final publication is available at http://www.springerlink.com). 29 pages, 1
figur
Universal properties of correlation transfer in integrate-and-fire neurons
One of the fundamental characteristics of a nonlinear system is how it
transfers correlations in its inputs to correlations in its outputs. This is
particularly important in the nervous system, where correlations between
spiking neurons are prominent. Using linear response and asymptotic methods for
pairs of unconnected integrate-and-fire (IF) neurons receiving white noise
inputs, we show that this correlation transfer depends on the output spike
firing rate in a strong, stereotyped manner, and is, surprisingly, almost
independent of the interspike variance. For cells receiving heterogeneous
inputs, we further show that correlation increases with the geometric mean
spiking rate in the same stereotyped manner, greatly extending the generality
of this relationship. We present an immediate consequence of this relationship
for population coding via tuning curves
Timescales of spike-train correlation for neural oscillators with common drive
We examine the effect of the phase-resetting curve (PRC) on the transfer of
correlated input signals into correlated output spikes in a class of neural
models receiving noisy, super-threshold stimulation. We use linear response
theory to approximate the spike correlation coefficient in terms of moments of
the associated exit time problem, and contrast the results for Type I vs. Type
II models and across the different timescales over which spike correlations can
be assessed. We find that, on long timescales, Type I oscillators transfer
correlations much more efficiently than Type II oscillators. On short
timescales this trend reverses, with the relative efficiency switching at a
timescale that depends on the mean and standard deviation of input currents.
This switch occurs over timescales that could be exploited by downstream
circuits
On the Correlation Between CO Absorption and Far-Ultraviolet Non-Linear Extinction Toward Galactic OB Stars
A sample of 59 sight lines to reddened Galactic OB stars was examined for
correlations of the strength of the CO Fourth Positive (A - X) absorption band
system with the ultraviolet interstellar extinction curve parameters. We used
archival high-dispersion NEWSIPS IUE spectra to measure the CO absorption for
comparison to parametric fits of the extinction curves from the literature. A
strong correlation with the non-linear far-UV curvature term was found with
greater absorption, normalized to E(B-V), being associated with more curvature.
A weaker trend with the linear extinction term was also found. Mechanisms for
enhancing CO in dust environments exhibiting high non-linear curvature are
discussed.Comment: 10 pages, including 6 figures. LaTeX2e (emulateapj5.sty). To appear
in ApJ, Sep 20, 200
MHD Stellar and Disk Winds: Application to Planetary Nebulae
MHD winds can emanate from both stars and surrounding accretion disks. It is
of interest to know how much wind power is available and which (if either) of
the two rotators dominates that power. We investigate this in the context of
multi-polar planetary nebulae (PNe) and proto-planetary nebulae (PPNe), for
which recent observations have revealed the need for a wind power source in
excess of that available from radiation driving, and a possible need for
magnetic shaping. We calculate the MHD wind power from a coupled disk and star,
where the former results from binary disruption. The resulting wind powers
depend only on the accretion rate and stellar properties. We find that if the
stellar envelope were initially slowly rotating, the disk wind would dominate
throughout the evolution. If the envelope of the star were rapidly rotating,
the stellar wind could initially be of comparable power to the disk wind until
the stellar wind carries away the star's angular momentum. Since an initially
rapidly rotating star can have its spin and magnetic axes misaligned to the
disk, multi-polar outflows can result from this disk wind system. For times
greater than a spin-down time, the post-AGB stellar wind is slaved to the disk
for both slow and rapid initial spin cases and the disk wind luminosity
dominates. We find a reasonably large parameter space where a hybrid star+disk
MHD driven wind is plausible and where both or either can account for PPNe and
PNe powers. We also speculate on the morphologies which may emerge from the
coupled system. The coupled winds might help explain the shapes of a number of
remarkable multi-shell or multi-polar nebulae. Magnetic activity such as X-ray
flares may be associated with the both central star and the disk and would be a
valuable diagnostic for the dynamical role of MHD processes in PNe.Comment: ApJ accepted version, incorporating some important revisions. 25
Pages, LaTex, + 5 fig
Analysis of sounding data from Porto Santo island during ASTEX
November 7, 1992.Includes bibliographical references.We present an analysis of the ASTEX radiosonde data obtained on Porto Santo Island during 1-28 June 1992. The data consists of 203 soundings and is available in two forms-Level I and Level II. The Level I data is the raw data produced by the real time software of the AIR radiosonde system. This data is at irregular pressure and height levels. Level II data consists of processed thermodynamic and wind data at a uniform vertical resolution of 10m, which essentially retains the highest possible vertical resolution in the original raw data. Plots of temperature and dew point temperature are presented for each of the 203 soundings taken during ASTEX. Plots of the 28 day means and of the diurnal variations are also presented. Accessibility of this data via anonymous ftp is also discussed
Recommended from our members
Trends in Clinical, Demographic, and Biochemical Characteristics of Patients with Acute Myocardial Infarction from 2003 to 2008: A Report from the American Heart Association Get with the Guidelines Coronary Artery Disease Program
Background: An analysis of the changes in the clinical and demographic characteristics of patients with acute myocardial infarction could identify successes and failures of risk factor identification and treatment of patients at increased risk for cardiovascular events. Methods and results: We reviewed data collected from 138 122 patients with acute myocardial infarction admitted from 2003 to 2008 to hospitals participating in the American Heart Association Get With The Guidelines Coronary Artery Disease program. Clinical, demographic, and laboratory characteristics were analyzed for each year stratified on the electrocardiogram at presentation. Patients with nonâST-segmentâelevation myocardial infarction were older, more likely to be women, and more likely to have hypertension, diabetes mellitus, and a history of past cardiovascular disease than were patients with ST-elevation myocardial infarction. In the overall patient sample, significant trends were observed of an increase over time in the proportions of nonâST-segmentâelevation myocardial infarction, patient age of 45 to 65 years, obesity, and female sex. The prevalence of diabetes mellitus decreased over time, whereas the prevalences of hypertension and smoking were substantial and unchanging. The prevalence of âlowâ high-density lipoprotein increased over time, whereas that of âhighâ low-density lipoprotein decreased. Stratum-specific univariate analysis revealed quantitative and qualitative differences between strata in time trends for numerous demographic, clinical, and biochemical measures. On multivariable analysis, there was concordance between strata with regard to the increase in prevalence of patients 45 to 65 years of age, obesity, and âlowâ high-density lipoprotein and the decrease in prevalence of âhighâ low-density lipoprotein. However, changes in trends in age distribution, sex ratio, and prevalence of smokers and the magnitude of change in diabetes mellitus prevalence differed between strata. Conclusions: There were notable differences in risk factors and patient characteristics among patients with ST-elevation myocardial infarction and those with nonâST-segmentâelevation myocardial infarction. The increasing prevalence of dysmetabolic markers in a growing proportion of patients with acute myocardial infarction suggests further opportunities for risk factor modification
Chlamydia trachomatis L2c infection in a porcine model produced urogenital pathology and failed to induce protective immune responses against re-infection
The current study was designed to evaluate the pathogenesis, pathology and immune response of female genital tract infection with Chlamydia trachomatis L2c, the most recently discovered lymphogranuloma venereum strain, using a porcine model of sexually transmitted infections. Pigs were mock infected, infected once or infected and re-infected intravaginally, and samples were obtained for chlamydial culture, gross and microscopic pathology, and humoral and cell-mediated immunity. Intravaginal inoculation of pigs with this bacterium resulted in an infection that was confined to the urogenital tract, where inflammation and pathology were caused that resembled what is seen in human infection. Re-infection resulted in more severe gross pathology than primary infection, and chlamydial colonization of the urogenital tract was similar for primary infected and re- infected pigs. This indicates that primary infection failed to induce protective immune responses against re-infection. Indeed, the proliferative responses of mononuclear cells from blood and lymphoid tissues to C. trachomatis strain L2c were never statistically different among groups, suggesting that C. trachomatis-specific lymphocytes were not generated following infection or re-infection. Nevertheless, anti-chlamydial antibodies were elicited in sera and vaginal secretions after primary infection and re-infection, clearly resulting in a secondary systemic and mucosal antibody response. While primary infection did not protect against reinfection, the porcine model is relevant for evaluating immune and pathogenic responses for emerging and known C. trachomatis strains to advance drug and/or vaccine development in humans
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