A randomized interventional clinical trial assessing the safety and effectiveness of PeaNoc XL tablets in managing joint pain and inflammation in arthritis patients [version 1; peer review: 2 approved]

Background: Globally, alternative medicine is used widely by most patients for several health challenges. To evaluate the effectiveness and safety of PeaNoc XL Tablet in managing pain and inflammation, a randomized clinical trial and systematic study was designed. PeaNoc XL Tablet has been widely utilized for pain and inflammation management, but no previous studies have examined its efficacy and safety. The aim of this study was to determine the clinical effectiveness and safety profile of PeaNoc XL in patients with arthritis experiencing joint pain and inflammation. Methods: A randomized, controlled, and an open-label trial was conducted. A total of 155 patients (18 to 60 years) with arthritis were enrolled for participation. Using computer-generated random sequences, the study population was divided into two groups in a randomized manner. Group A received Standard therapy and Group B received Standard therapy with PeaNoc XL Tablet 400mg (two tablets OD after food). Results: Out of 155 patients, a total of 83 individuals were excluded from the study, leaving 72 patients who were randomly assigned to either Group A (n=36) or Group B (n=36). The administration of PeaNoc XL as an adjunct to standard therapy resulted in a significant reduction in levels of TNF-α (P<0.01), IL-1β (P<0.001), IL-6 (P<0.01), and CRP (P<0.01) in arthritis patients experiencing joint pain and inflammation. Conversely, no notable differences were observed from the baseline in the standard therapy group. Conclusions: After 12 weeks of supplementation of PeaNoc XL tablets, as an add-on therapy helps in the reduction of pain score, joint stiffness, and physical stiffness. Trial registration:  CTRI/2022/10/046693

How To Make, Place, and Remove Transphyseal Staples

Foals can have angular and flexural limb deformities with or without a rotational component. Most foals are born with at least some degree of limb deformity of either type, and carpal valgus is the most frequently encountered type. Methods employed to surgically correct angular limb deformities include hemicircumferential transection of periosteum and periosteal elevation (or periosteal stripping) and transphyseal bridging (or growth retardation). Transphyseal bridging is accomplished with screws and wires, staples, or with a lag screw across the physis. Combinations of stripping and growth retardation have also been used. Corrective trimming of the hoof is almost always recommended, and owners are instructed to restrict exercise.This is a manuscript of a proceeding from 56th Annual Convention of the American Association of Equine Practitioners (2011): 1-3. Posted with permission.</p