Histopathological distribution of thyroid cancers: A retrospective analysis of 570 patients

Aim: Thyroid cancers are the most commonly encountered endocrine system malignancies.  The incidence continues to rise worldwide. Our aim in this study is to investigate the frequency and histopathological subtypes of thyroid cancer in our clinic. Methods: The present study was conducted with 3614 patients who were followed up in our endocrinology and general surgery clinic and operated with the diagnosis of multinodular and/or nodular goiter between 2015 and 2021. The histopathological types and information of patients diagnosed with thyroid cancer were obtained retrospectively from the pathology reports. Among the patients included in the study, a total of 570 people who were reported to have thyroid cancer due to histopathology were included in the study. Results: The data of a total of 3614 biopsy reports were examined for the study. Among these patients, 570 (421 females, 149 males) were operated and whose pathology reports were accessed were included in the study. The mean age of the patients was 49.12±10.4 years. As a result of the operations, malign postoperative tissue histopathology was 98.9% (n=564), and uncertain malignancy potential was reported to be 1.0% (n=6). In our study, the histopathological distribution of thyroid cancers was as follows; thyroid papillary cancer 89.4% (n=510), follicular cancer 7.3% (n=42), medullary cancer 2.1% (n=12), and malignancy potential uncertain 1.0% (n=6). Conclusion: The results of our study suggest that thyroid cancers are more common in women in our country, in parallel with the similar rates reported in the literature, with the increase worldwide

A Very Rare Presentation of Multiple Myeloma: Unilateral Raccoon Eye

Multiple myeloma (MM), the second most common hematological malignancy, is caused by the accumulation of monoclonal plasma cells in bone marrow. It accounts for 10–15% of deaths from hematological malignancies and approximately 2% of deaths from cancer. The median age at presentation is 70 years old. The diagnosis is incidental in 30% of cases. MM is often discovered through routine blood screening with a large gap between the total protein and the albumin levels.Two thirds of patients complain of bone pain, especially lower back pain. MM could be diagnosed after a pathologic fracture occurs in one third of patients. Presentation with symptoms related to hyperviscosity, hypercalcemia and bleeding tendency could also be observed. A rare presentation of MM is peri-orbital ecchymotic lesion (raccoon eye). Here, we report a 64 years old, male patient presented with unilateral raccoon eye and high erythrocyte sedimentation rate (ESR) to internal medicine outpatient. The patient was referred to hematology outpatient and was diagnosed with multiple myeloma

The relationship between Vitamin D deficiency and polycystic ovary syndrome

Background: Vitamin D deficiency is frequently seen in patients with polycystic ovary syndrome (PCOS) and has been shown to exhibit multiple effects on the disease process. The purpose of this study was to investigate the role of vitamin D deficiency in complex PCOS pathophysiological pathways. Methods: Two hundred sixty-seven patients with PCOS were divided into two groups Group 1 with 25(OH)D3 deficiency, and Group 2 with normal 25(OH)D3. Biochemical and hormonal parameters (androgen hormones, gonadotropins, and thyroid function tests) were compared between the two groups. Results: Eighty-six percent of the patients (n=231) were in Group 1 and 14% (n=36) in Group 2. Statistically significantly higher concentrations of serum testosterone, dehydroepiandrosterone-sulfate and LH were determined in Group 1 (p<0.05). 25(OH)D3 concentrations were negatively correlated with body mass index (r=-0.459), serum testosterone (r =-0.374) and dehydroepiandrosterone-sulfate levels (r=-0.418); (all; p< 0.05). Conclusion: The study findings show that low 25(OH)D3 levels are associated with high androgen levels in women with PCOS. Vitamin D deficiency should be considered as an additional risk factor in the development of PCOS. We think that providing vitamin D supplementation for women from identified deficiency areas can reduce the risk of PCOS development.WOS:0006774662000132-s2.0-85098057003PubMed: 3439425

Investigating Anxiety, Depression and Obsessive-Compulsive Disorders (OCD) among healthcare workersin COVID-19 unit and the control group

To investigate anxiety, depression, and Obsessive-Compulsive Disorders (OCDs) among the healthcare workers (HCWs) to compare the healthcare workers in COVID positive services with the control group. This cross-sectional study was conducted on 198 subjects participating in the study. To test the difference between the two groups involved in COVID-19 hospitalization section and normal section in Anxiety, Depression, and Obsessive-Compulsive Disorders Scale, two sample independent t-tests, however, WelchSatterthwaite P Values were considered for test significance. The categorical variables (sex, branch type, etc.) were also tested using the Chi-Square test to make sure that the two samples were not influenced by the demographics of the population. 198 subjectspartici pated in the study, among whom 72% were female and 28.3% were male. 130 participants (66%) worked in COVID and 68 participants (35%) worked in other sections.The mean age of the two samples was close to 35 and most of them (~45%) were nurses. 57% of the pooled samples had Emergency Response Experience (ERE).There was no significant difference between the two groups regarding sex, education, marital status, and ERE, however, the branch type showed major differences between the two groups(P-value &lt; 0.08). The age difference between the two groups was also insignificant. Working in the COVID-19 section significantly increased anxiety scores from 9.62 to 13.15 with a P-value of [Med-Science 2020; 9(4.000): 1072-5

Doppler ultrasonographic findings in cases with Hashimoto thyroiditis

Objective: To investigate the effect of thyroid-stimulating hormone (TSH) levels on hemodynamic indexes in color doppler ultrasonography in patients with Hashimoto's disease Design: Prospective observational study Setting: Departmant of Endocrinology, Medical Park Hospital, Ordu, Turkey Subjects: One hundred and twelve patients Intervention: The patients were divided into two groups: Group 1, TSH: 0.35-4.94 mIU/L; and Group 2, TSH >4.94 mIU/L. The mean peak systolic velocity (mPSV), mean end diastolic velocity (EDV) and mean resistive index (RI) of the inferior thyroid artery were measured using doppler ultrasonography at the appropriate angle (45-60 degrees C). Main outcome measure: The mPSV, EDV and RI of the inferior thyroid artery Results: A total of 48.21% of the patients (n=54) were in Group 1 and 51.78% of them (n=58) were in Group 2. In our study, we found that as the TSH levels increased, the thyroid blood flow and RI decreased in patients with Hashimoto's disease and with clinical and subclinical hypothyroidism compared with normal ones. Conclusion: The TSH level in Hashimoto's disease and the vascular RI increases as the parenchymal damage increases.WOS:0006132291000072-s2.0-8509887988

The relationship between vitamin D deficiency and erythrocyte sedimentation rate in patients with diabetes

Conclusion: The present study revealed that ESR is higher in T2DM patients with vitamin D deficiency than patients with sufficient vitamin D. There was an inverse association between ESR and vitamin D levels. Furthermore, vitamin D deficiency was related to poor glycemic control

The Relation between Serum Vitamin D Levels and Hashimoto Thyroiditis in Women

Conclusion: Women with HT thyroiditis have lower vitamin D levels compared to women without HT thyroiditis. We determined that serum 25-OH D-3 insufficiency was 1.7 times more likely to be present in patients with HT. This insufficiency may increase the risk of HT disease

Seizure Due To Hypocalcemia Caused by Late Onset Hypoparathyroism after Thyroid Surgery

The most common complication of thyroid surgery is hypocalcemia. Fortunately, it is often slight and transient, but sometimes it can be critical and persistent. There have been a number of reports of seizures caused by hypocalcemia following thyroid surgery. In this report, we reported a female patient who presented with tonic-clonic seizures due to hypocalcemia twenty years after thyroid surgery. A 63-year-old female patient was brought to emergency department with tonic-clonic seizures she experienced for the first time in her life. The patients medical history included subtotal thyroidectomy that was performed 20 years ago, although subtotal thyroidectomy, she had hypoparathyroidism and post-surgery calcitriol and calcium supplementation, and inconsistent follow-up and use of the prescribed supplements. Chvosteks and Trousseaus signs were present, which indicated hypocalcemia. Laboratory examination included a calcium level of 5.6 mg/ dL , an albumin level of 4.3 gr /L, a phosphorus level of 7.5 mg/ dL, a parathyroid hormone (PTH) level of 9.0 pg / mL (indicative of iatrogenic hypoparathyroidism). Parenteral calcium supplementation (200 mg calcium within 50 100 mL 5% dextrose, intravenously, for 5-10 min) was initiated, followed immediately by oral calcium supplementation 3 g/ d, calcitriol 0.5 &#956;g/ day, and conventional vitamin D (1000 IU/day ). During the 6 months of the outpatient follow-up, the patient did not have any other seizures and at the seventh month of the follow- up, her calcium level was measured and found to be 8.8 mg/ dL. We described a patient that presented with tonic-clonic seizures due to postoperative chronic hypoparathyroidism that was not detected before. Hypocalcemia should be considered in all the patients that present with seizure and a history of neck surgery or radiation therapy. [Med-Science 2015; 4(3.000): 2552-8

The relationship between neutrophil to lymphocyte ratio and metabolic syndrome in patients with type 2 diabetes

Metabolic syndrome (MetS) has been shown to be associated with inflammation. However, in diabetic patients with MetS, its relationship with the neutrophil to lymphocyte ratio (NLR) as a novel inflammation marker is unclear. The aim of the study was to investigate the association between NLR and MetS in patients with type 2 diabetes mellitus. It was a cross-sectional study which included 261 consecutive patients (mean age 56.7 +/- 10.5 years, 56.7% female) with type 2 diabetes. NLR and other clinical and laboratory parameters of patients with and without MetS were evaluated. The prevalence of MetS was 85.8%. The NLR was higher in patients with MetS than without MetS (p = 0.001). There was a significant correlation between the NLR and the number of MetS components (r = 0.147, p = 0.017). Logistic regression analysis showed that an elevated NLR value was an independent predictor of MetS. The receiver operating curve analysis suggested that the optimum NLR cut-off point for MetS was 1.50 with a sensitivity of 74.6% and specificity of 52%. There is a significant relationship between NLR and MetS prevalence in patients with type 2 diabetes mellitus. NLR seems as an independent predictor of MetS in diabetic patients