Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population

Background Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in renin-angiotensin system (RAS) and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D) polymorphism of ACE gene. Objective The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed

Electrohydraulic comminution studies

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The Relationship between Melatonin and Cannabinoid-1 Receptor in Cortical Dysplasia Generated Rats

WOS: 000343369600016Objectives: Cortical dysplasia is a developmental malformation that occurs as a result of defects in neuronal proliferation, migration and organization during the formation of brain cortex layers. Cannabinoid-1 Receptor (CB1R) plays a role in brain cortex development. Melatonin neuroprotective is an agent. In this study using an experimental cortical dysplasia model, CB1R expression and the effect of melatonin on CB1R were investigated. Methods: Eighteen female Wistar albino rats were randomly divided into three groups (n=6). A single dose of intraperitoneal (i.p) saline (20 ml/kg) was administered in the 15th day of pregnancy in the rats group 1 (sham group). A single dose of i.p BCNU (20 mg/kg) was administered in the 15th day of pregnancy in the rats in group 2 (BCNU) and group 3 (BCNU+ Melatonin). In addition, i.p melatonin (10 mg/kg) starting on day 15 of pregnancy and continuing until the day of delivery were administered to the rats in group 3 (BCNU+ Melatonin). Newborn brain sections were investigated using Luxol fast blue and anti-CB1R staining. Results: While the sham group had cerebral cortex stratification compatible with the normal newborn histology, it was observed that the stratification was disrupted in the group 2 and group 3. In the observed brain regions (cerebral cortex, cerebellar cortex and hippocampus), it was observed that CB1R immunoreactivity decreased in group 2 and 3. Conclusion: In an experimental cortical dysplasia model, it was seen that the administration of melatonin revealed a protective effect against the decrease in CB1R expression. It has been suggested that a decrease in CB1R expression would also play a role in cortical dysplasia formation mechanisms

Tear Nitric Oxide Levels in Behcet's Disease

The aim of this study was to evaluate the tear nitric oxide (NO) level in patients with Behcet's disease and to compare it with that in healthy subjects

Macroeconomic factors and equity returns in Borsa Istanbul

This paper investigates equity return exposure to various macroeconomic factors and the performance of factor betas in predicting the cross-sectional variation in stock returns. We utilize a two-step procedure to directly test the implications of the Arbitrage Pricing Theory. First, we calculate monthly factor betas and then, we estimate the sensitivity of equity returns towards the factor betas. We find that (i) there exists a negative and significant relation between interest rate betas and future equity returns; (ii) the inclusion of market, book-to-market, size and momentum factor betas does not subsume the predictive power of the interest rate beta; and (iii) these results are driven by the debt-to-equity ratios of individual firms. We conclude that the financial leverage driven sensitivity of returns towards interest rates is a priced risk factor in the Turkish stock market

The Morpho-functional Evaluation of Retina in Amblyopia

Purpose: To investigate the morphological or functional differences of retina in amblyopia

Performance assessment of a marine freshwater generator through exergetic optimization

The objective of this study is to examine the effect of operating parameters on the freshwater generation capacity of a vacuum type and low-temperature single-stage freshwater generator and the exergy destruction of the condenser and evaporator sections. Evaporator and condenser, which are plate type heat exchangers, are modeled using the e-NTU method. Energy and exergy analyses were applied to the control volume enclosing the condenser and evaporator to find the freshwater production rate and to investigate the system performance. A parametric study was performed to assess the effects of the jacket water mass flow rate, the seawater salinity, and the seawater temperature on the output parameters (fresh water production rate and specific exergy destruction). In addition, an optimization study was performed using the Taguchi method to maximize the freshwater production rate and minimize the exergy destruction rates of the condenser and evaporator. The results derived from the parametric study showed that the seawater temperature of 31.88 degrees C and jacket water mass flow rate of 72,000 kg/h are the required values to obtain the maximum freshwater generation capacity (30 m(3)/day). When the salinity increases from 3 g/kg to 41 g/kg (3000 to 41,000 ppm), the freshwater production rate increases by 2.18% and 5.06% under the constant seawater temperature (23 degrees C) and the jacket water mass flow rate (58,500 kg/h), respectively. The optimization results revealed the conditions to obtain the maximum fresh water production rate and the minimum exergy destruction. (C) 2019 Elsevier Ltd. All rights reserved

Personality change after ‘flow diverter implantation’ for intracranial aneurysm in a patient with stroke: A case report

Objective: This study aimed to present a patient with psychiatric symptoms that occur after flow diverter stent placement in a posterior communicating artery (PComA) aneurysm in a patient. Design: A case study. Method: We performed cranial magnetic resonance imaging (MRI), magnetic resonance angiography, computed tomography angiography, neuropsychological tests, Levenson Self-Report Psychopathy Scale (LSRP), and a 25-item version of the Wender Utah Rating Scale (WURS-25). The patient’s recent MRI was compared with previous MRIs. Neuropsychological testing consisted of a clinical interview, clinical assessment of frontal lobe syndrome, and tests evaluating the prefrontal cortex functions (Wisconsin Card Sorting Test-128 card version and Iowa Gambling Test). Results: Our results showed that the patient’s personality change and psychiatric symptoms occurred after the stent placement. Symptoms were still present at evaluation two and a half years after stent placement. Conclusion: The study demonstrates personality changes and psychiatric symptoms that might occur as complications following the placement of a flow diverter for incidentally detected aneurysm