Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer

Objective: We aimed to investigate the association of the frequency of three single-nucleotide polymorphisms [glucose transporter isoform 1 (GLUT1) reference single-nucleotide polymorphism (rs) 710218, hypoxia-inducible factor 1 alpha (HIF1α) rs11549465, and T-box transcription factor protein 21 (TBX21) rs17250932], which have been proved to be related with various benign and malignant diseases, with the development of laryngeal cancer and its size and grade.Methods: In this study, we included 35 patients with laryngeal cancer and 35 volunteers at least 30 years old who had smoked for at least 20 years. DNA was obtained from the blood samples of the participants using an isolation kit. Then, polymorphisms for both the groups were determined using real-time polymerase chain reaction.Results: No significant differences were detected regarding the genotype and allele frequencies in the three polymorphisms assessed between the two groups. In the patient group, on examining the association of polymorphisms with tumor size and grade, no significant relation was observed in three polymorphisms regarding the related parameters.Conclusion: GLUT1, HIF1α, and TBX21 polymorphisms have no impact on the development of laryngeal cancer

A novel index in healthy infants and children — subarachnoid space: ventricle ratio

Background: The subarachnoid space (SAS) and ventricular width (VW) in normalinfants and children were studied with ultrasonography to provide the objectivemeasurement and define a normal range for these measurements. The additional aim was to determine the stable ratio as a SAS/VW.Materials and methods: A total of 100 healthy subjects, including 48 males and52 females, were studied. The cases were divided into 3 age groups: 0–6 months(n = 65), 7–12 months (n = 24) and > 13 months (n = 11). Transfontanel ultrasonography was performed in all the cases. SAS, VW and the SAS/VW ratios were calculated. The study was approved by the ethical committee. All parents wereinformed about the sonographic examination and their approvals were taken.Results: SAS was calculated as 3.1 (0.5–6) mm and VW was calculated as 3.6(1.3–5) mm. SAS/VW ratio was 0.9 ± 0.3. There was no statistically significant difference among SAS, VW and SAS/VW ratios in 3–97 percentile group (p > 0.05).Conclusions: Ultrasonography can be used as a practicable and reproducible modalityin the measurement of SAS and VW in healthy children. It is a non-invasivemethod and allows for serial follow-up. SAS/VW ratio can be used as an index inhealthy children

The Importance of Prostate-Specific Membrane Antigen Expression in Carotid Body Paragangliomas

Objective:Prostate-specific membrane antigen (PSMA) is a transmembrane protein expressed in prostate cancer. It is, however, also expressed in the neovasculature of some non-prostatic solid tumors. Carotid body paragangliomas (CBPs) are highly vascular neoplasms. In this study, we aimed to investigate the possible role of PSMA expression in CBPs. There are no studies in the literature that report to have investigated the relationship between PSMA and CBPs.Methods:This study is a retrospective analysis of cases diagnosed with CBP based on their demographic, clinical, radiological, surgical and immunohistochemical findings. Immunohistochemical examination results of Ki-67, S100, synaptophysin, chromogranin were retrieved from patient files. Then, the paraffin blocks of CBPs specimens, stained by PSMA-antibody by immunohistochemical methods were examined histopathologically.Results:The number of patients operated on for CBP was 12 (four men and eight women). Ten out of 12 specimens were suitable for staining and histopathological examination. Capsular and/or vascular invasions of tumors were seen in complicated cases. Intratumoral vascular PSMA expression was seen in all specimens except one. Extratumoral vascular PSMA expression was not detected in any of the cases. Tumoral cell PSMA staining was seen in six of ten cases.Conclusion:We found higher intratumoral vascular expressions of PSMA nearly in all CBPs, but we could not assess the statistical significance because of the small number of specimens. These data might be a guide for future studies that are planned for either diagnostic or therapeutic approaches to CBPs

Effüzyonlu otitis medialı olgular ile obstrüktif adenoid hiperplazili olguların serum ve adenoid dokularındaki bazı immünolojik parametrelerin araştırılması

TEZ3319Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 1999.Kaynakça (s. 53-60) var.ix, 60 s. ; 30 cm.

OLPT CONDUCTIVITY IN WOLLASTONITE INLAID NR/SBR TYPE ELASTOMER BASED MATERIAL

The electrical properties of wollastonite inlaid NR/SBR type elastomer based material have been evaluated. Electrical properties of the samples were measured in the temperature range of 303 to 453 K and the frequency range of 100 Hz - 40 MHz. All electrically measured parameters were given anomalies at 385 K. Only one type of dielectric relaxation process have been observed for all measurements. Physical parameters characterizing the dielectric behavior have been obtained by fitting the experimental results in the modified Debye equation. The activation energy which is thermally activated by dielectric relaxation process have been calculated to be 0.58 eV. DC conductivity increasing by temperature has been explained with the help of VFT model whereas the AC one has been clarified by the OLPT model

Sağlık bilimleri öğrencilerinin tamamlayıcı ve alternatif tedavilerle ilgili bilgi, tutum ve inanışlarının araştırılması

Amaç: Tamamlayıcı ve Alternatif Tedavilere (TAT) olan ilgi son yıllarda artış göstermekle birlikte bu konudaki bilgi düzeyi merakkonusudur. Geleceğin sağlık profesyonellerinin bu konudaki fikirleri önemlidir. Bu nedenle çalışmamız sağlık bilimleriöğrencilerinin TAT’la ilgili bilgi, tutum ve inanışlarını incelemek amacıyla gerçekleştirildi.Yöntem: Çalışmaya yaş ortalaması 20,68±0,43 yıl olan, Fizyoterapi ve Rehabilitasyon, Hemşirelik ve Ebelik öğrencilerindenoluşan toplam 821 katılımcı dahil edildi. Katılımcıların demografik bilgileri kaydedildikten sonra literatür taranarak oluşturulanTAT Anketi uygulandı.Bulgular: Katılımcıların % 28’i TAT uygulamaları hakkında bilgi sahibiydi ve %92’si de TAT uygulamalarının etkinliğineinanmakta idi. Bilgi edinme kaynaklarının çevre (%49) ve internet (%29) olduğu, ayrıca %76’sının TAT yöntemlerinin müfredattayer almasını istediği belirlendi. Katılımcılar diyet (%32,5) ve masaj (%32,5)’ın en etkili yöntem olduğunu belirttiler. TATyöntemlerini kullanma durumları incelendiğinde; %52,4 ile masaj, %40,8 ile bitkisel tedavi, %40,2 ile kaplıca ve %38,7 ilediyet olduğu saptandı. Faydalanma durumlarına bakıldığında ise %42 ile masaj, %30 ile bitkisel tedavi, %26 ile kaplıca olduğubelirlendi.Sonuç: Sonuç olarak çalışmamızda sağlık bilimleri öğrencilerinin TAT yöntemlerinden en çok diyet ve masaj ile ilgili olumlututum ve bilgi sahibi iken diğer TAT yöntemleri hakkında bilgi düzeylerinin yetersiz olduğu, ancak tutum ve inanışlarının olumluolduğu belirlendi. Bilgi edinme kaynakları da göz önünde tutulduğunda sağlık bilimleri müfredatına TAT yöntemlerinineklenmesinin, bilgi düzeyinin artırılması ve yanlış uygulamaların önlPurpose: Although the interest in Complementary and Alternative Therapies (CAT) has increased in recent years, the level ofknowledge on this subject is unsettled. The opinions of future health professionals on this subject are very important. For thisreason, the present study was carried out in order to examine the knowledge, attitude, and beliefs of health science studentson CATs.Methods: The present study involved 821 students (mean age 20.68±0.43 years) from Physiotherapy and Rehabilitation,Nursing, and Midwifery disciplines. The CAT Survey, which was prepared by reviewing the literature, was conducted afterrecording the demographic data of participants.Results: It was determined that 28% of participants had knowledge about CATs and 92% believed in efficiency of CAT practices.The sources of information were environment (49%) and internet (29%) and it was found that 76% of participants want the CATmethods to be involved in curricula. The participants stated that diet (32.5%) and massage (32.5%) were the most effectivemethods. Examining the use of CAT methods, it was found that 52.4% has used massage, 40.8% used herbal therapy, 40.2%used SPA, and 38.7% used diet. Examining the benefits obtained, the results were found to be 42% for massage, 30% for herbaltherapy, and 26% for SPA.Conclusion: It was determined that health science students have positive attitude and knowledge about diet and massage atmost while there is a lack of knowledge on other CAT approaches although they have positive attitudes and beliefs. Examiningthe sources of information, it is thought that adding the CAT methods into curricula of health sciences would be useful inincreasing the level of knowledge and preventing malpractices.&nbsp;</p