Mogu li hemocitometrijski parametri poslužiti kao biološki biljezi u razlikovanju adrenalnih adenoma i karcinoma te u prognozi adrenokortikalnih karcinoma?

Recently, studies have reported that inflammatory response and elevated platelet counts are associated with several cancers. In the present study, we aimed to evaluate hemocytometer parameters in differentiating adrenal adenoma and carcinoma, and the prognostic utility of hemocytometer parameters in adrenocortical carcinoma (ACC). We included 30 patients with nonfunctional adrenal adenoma and 13 patients with ACC having undergone surgery between 2005 and 2017 and followed up postoperatively at our centre. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), red blood cell distribution width (RDW), mean platelet volume (MPV) and plateletcrit (PCT) were evaluated preoperatively in all patients included in the study. There was a significant difference between the adrenal adenoma and ACC groups in terms of neutrophil and lymphocyte counts, NLR and PLR. There was no significant difference between the two groups in terms of platelet count and MPV, but PCT levels were significantly lower in ACC group. There was no statistically significant difference between recurrent and/or metastasis positive patients and negative ones according to NLR, PLR, RDW and MPV. There was a statistically significant difference in RDW levels and tumor diameter between the groups. Our study is the first to evaluate hemocytometer parameters in differentiating adrenal adenomas and carcinomas, and also in the prognosis of ACC. The present study suggested that the hemocytometer parameters may be a marker in the differential diagnosis of adrenal adenomas and carcinomas. However, our study also showed that these parameters had no prognostic value in ACC.Nedavna istraživanja pokazuju da su upalni odgovor i povišeni trombociti udruženi s nekim vrstama karcinoma. Cilj našega istraživanja bio je procijeniti hemocitometrijske parametre u razlikovanju adrenalnog adenoma i karcinoma, kao i prognostičku vrijednost hemocitometrijskih parametara u adrenokortikalnom karcinomu (adrenocortical carcinoma, ACC). U istraživanje smo uključili 30 bolesnika s nefunkcionalnim adrenalnim adenomom i 13 bolesnika s ACC operiranih između 2005. i 2017. godine i poslije operacije praćene u našoj ustanovi. Kod svih bolesnika uključenih u studiju prijeoperacijski su izmjereni sljedeći parametri: omjer neutrofila i limfocita (neutrophil/lymphocyte ratio, NLR), omjer trombocita i limfocita (platelet/lymphocyte ratio, PLR ), širina distribucije eritrocita (red blood cell distribution width, RDW ), srednji volumen trombocita (mean platelet volume, MPV) i pleteletkrit (PCT). Utvrđena je statistički značajna razlika između skupina bolesnika s adrenalnim adenomom i onih s ACC u broju neutrofila i limfocita, NLR i PLR. Nije bilo značajne razlike među skupinama u broju trombocita i MPV, ali su razine PCT bile značajno niže u skupini s ACC. Nije bilo statistički značajne razlike u NLR, PLR, RDW i MPV između bolesnika s opetovanim ACC i/ili metastazama i onih bez tih stanja. Statistički značajna razlika između skupina nađena je za razine RDW i promjer tumora. Naše istraživanje je prvo te vrste u kojem su se procjenjivali hemocitometrijski parametri u razlikovanju adrenalnih adenoma i karcinoma te u prognozi ACC. Rezultati studije ukazuju na to da bi se hemocitometrijski parametri mogli primijeniti kao biljezi u diferencijalnoj dijagnostici adrenalnih adenoma i karcinoma. Međutim, naše je istraživanje pokazalo kako ovi parametri nemaju prognostičku vrijednost kod ACC

Structural and magnetic characterisation of Co substituted Ni2MnSb Heusler alloy: effect of cobalt substitution on magnetism and Curie temperature

In this study, Ni2-xCoxMnSb full-Heusler alloys (1.00 <= x <= 1.75) were prepared by arc melting process, and examined by X-ray diffraction (XRD), scanning electron microscopy (SEM), and SQUID. The L2(1)crystal structure of the synthesised Heusler alloy was confirmed by XRD patterns, and it was observed that the use of Co instead of Ni caused a decrease in the interatomic distance. The magnetisation results revealed that all samples show ferromagnetic (FM) behaviour, and substitution Co for Ni leads to increasing FM interactions in the samples. The calculated magnetic moment per formula unit increase from 4.38 mu B(x = 1) to 5.17 mu B (x = 1.75). On the other hand, the increase in FM interaction caused an increase in ferromagnetic-paramagnetic (PM) phase transition (T-C) temperatures from 513 (x = 1) to 568 K (x = 1.75). The ability to control the Curie temperature with Co substitution makes these alloys suitable candidates for future spintronics and magnetoelectronic applications

Tunnel/Layer Composite Na0.44_{0.44}MnO2_{2} Cathode Material with Enhanced Structural Stability via Cobalt Doping for Sodium-Ion Batteries

Sodium-ion batteries (SIBs) are the most promising alternative to lithium-ion batteries (LIBs) due to their low cost and environmental friendliness; therefore, enhancing the performance of SIBs’ components is crucial. Although most of the studies have focused on single-phase cathode electrodes, these materials have difficulty in meeting the requirements in practice. At this point, composite materials show superior performance due to balancing different structures and are offered as an alternative to single-phase cathodes. In this study, we synthesized a Na$_{0.44}$MnO$_2$/Na$_{0.7}$MnO$_{2.05}$ composite material in a single step with cobalt substitution. Changes in the crystal structure and the physical and electrochemical properties of the composite and bare structures were studied. We report that even if the initial capacity is slightly lower, the rate and cyclic performance of the 1% Co-substituted composite sample (CO10) are superior to the undoped Na$_{0.44}$MnO$_2$ (NMO) and 5% Co-substituted (CO50) samples after 100 cycles. The results show that with the composite cathode phase transformations are suppressed, structural degradation is prevented, and better battery performance is achieved

Investigation of physical and electrochemical properties of Ni-doped Tunnel/P2 hybrid Na0.44_{0.44}MnO2_2 cathode material for sodium-ion batteries

The increasing demand for energy in recent years has accelerated the efforts to increase the efficiency of energy storage systems. Although lithium-ion batteries are very popular in energy storage systems, the dramatic increase in costs due to the decrease in lithium resources has greatly increased the interest in sodium-ion batteries. Na$_{0.44}$MnO$_2$ has recently received increasing attention due to the fact that the tunnel structures in the crystal structure are suitable for the diffusion of Na ions. However, rapid structural degradation is an important problem that must be overcome to move into practical applications. In this study, the tunnel/P2 hybrid type Na$_{0.44}$MnO$_2$ was synthesized by a one-step heat treatment with the Ni substitution to Mn sites for improving cyclic performance. It was demonstrated by various physical analyses, that biphasic hybrid material starts forming with Ni substitution, and Ni occupied the Mn sites in the P2 phase. Electrochemical measurements provide that after 100 cycles at 0.3C, while Na$_{0.44}$MnO$_2$ has 77% capacity retention, 1% and 5% Ni substituted samples have 86.4% and 77.3%, respectively. The results show that tunnel-P2 hybrid cathode materials can be developed for practical applications in sodium-ion batteries

Curative Result with Primary Medical Therapy in an Elderly Acromegaly Patient

In acromegaly, transsphenoidal hypophysectomy is the primary treatment of choice. Medical treatment is performed on patients uncontrollable with surgery. Indications for primary medical treatment or medical treatment prior to surgery are limited to patients with macroadenoma with high risk for surgery due to cardiac and respiratory problems. Medical treatment is not applied on patients with microadenoma due to the high chance of cure with surgical option. Seventy-five years-old female patient was admitted in our clinic with complaints of drowsiness, fatigue and growth in hands and feet. Patients IGF1level was measured 516 ng/ml (64-118 ng/ml normal range for age and gender) and in the magnetic resonance imaging of the pituitary; an adenoma, 2x2 mm in size, was detected. Octreotide LAR therapy was begun 10 mg per month considering the age of the patient. IGF1 level was measured as 129ng/ml and growth hormone (GH) as 0.65ng/ml (0.06-5 ng/ml normal range) at the end of the third month of treatment. On the MRI carried out in the 9th month of treatment, it was observed that the pituitary was compatible with partial empty sella and no adenoma was determined. In our case of acromegaly with microadenoma, taking into account the age and medical condition of the patient, primary medical therapy was required. Although a low dose of octreotide LAR was implemented, primary medical therapy has been effective in controlling biochemical parameters. Moreover, it was observed that the tumor completely disappeared and is considered a curative result. Therefore, primary medical treatment of acromegaly should be among the options in selected patients with microadenomas. [Med-Science 2014; 3(4.000): 1697-707

Medicine Science 2014;3(4):1697-707 Primary Medical Therapy and Acromegaly Case Report Curative Result with Primary Medical Therapy in an Elderly Acromegaly Patient

Abstrac

Relationship between two estrogen receptor-alpha gene polymorphisms and angiographic coronary artery disease

Objective: To investigate the association of estrogen receptor-alpha Pvull and Btgl polymorphisms with angiographic presence and severity of coronary artery disease (CAD)

An unusual case of adult-onset multi-systemic Langerhans cell histiocytosis with perianal and incident thyroid involvement

Langerhans cell histiocytosis (LCH) is a rare sporadic disease characterized by histiocytic neoplastic infiltration of various organ systems and a wide spectrum of clinical manifestations, ranging from benign and self-limiting to lethal. Herein, we report a rare case of adult-onset multi-systemic LCH in a 36-year-old male patient with an initial perianal presentation and incidental finding of subsequent thyroid gland involvement in the follow-up period. The patient with a history of perianal LCH treated with surgical excision and local radiotherapy was referred to our Endocrinology Department upon detection of hypermetabolic nodular lesions in the left lateral lobe of thyroid gland on positron emission tomography–computed tomography (PET/CT) scan in the nineth month of follow-up. Current evaluation revealed euthyroid status, a hypoechoic solid lesion of 13 × 9 mm in size with irregular borders in the left thyroid lobe on thyroid USG and cytologic assessment of thyroid nodule. The patient was diagnosed with suspected, oncocytic lesion, Hashimoto thyroiditis or LCH. The patient underwent total thyroidectomy and pathological assessment confirmed the diagnosis of Langerhans cell histiocytosis. Assessments in the sixth month of postoperative follow-up revealed euthyroid status with no thyroid tissue remnants or pathological lymph node on thyroid USG. In view of the multifocal lesions indicating multi-system disease, a systemic chemotherapy protocol with combination of prednisone (PRED) and vinblastine (VBL) has been planned by the hematology department

Pd-NHC complex catalyzed C-H bond activation reactions of caffeine and 2-isobuthylthiazole

A series of new Pd-NHC complexes were synthesized, characterized, and utilized as catalysts on 8-(hetero)ary-lation of xanthines and C-5 (hetero)arylation of 2-isobuthylthiazole. All the synthesized derivatives were characterized by NMR, Q-TOF-LC/MS, FTIR, and X-ray (for 4a, 5a, and 5b) analysis. In addition, DFT calculations and computational NBO studies for Pd-NHC complexes were examined, and HOMO and LUMO energy levels and electron density of each Pd-NHC complex were defined. 4a-c and 5a-b complexes showed good catalytic activity in C-H bond activation reactions. DFT studies have also been conducted to examine the reaction mechanism following the CMD pathway. Complex 5a was chosen as a representative catalyst for the reaction of unsubstituted phenyl with caffeine and 2-isobuthylthiazole. Although the delta E values of the complexes are so close, slight difference in the catalytic activity were observed for 4a-c and 5a-b. Since this low delta E value facilitates the oxidative addition reaction of (hetero)aryl bromides, thanks to this catalytic system, new 8-(hetero)aryl xan-thines and 5-(hetero)aryl thiazole derivatives could be synthesized with high yields and low catalyst loading