Dutch disease-cum-financialization booms and external balance cycles in developing countries

We formally investigate the medium-to-long-run dynamics emerging out of a Dutch disease-cum-financialization phenomenon. We take inspiration from the most recent Colombian development pattern. The “pure” Dutch disease first causes deindustrialization by permanently appreciating the economy’s exchange rate in the long run. Financialization, i.e. booming capital inflows taking place in a climate of natural resource-led financial over-optimism, causes medium-run exchange rate volatility and macroeconomic instability. This jeopardizes manufacturing development even further by raising macroeconomic uncertainty. We advise the adoption of capital controls and a developmentalist monetary policy to tackle these two distinct but often intertwined phenomena

“Sofa and Facebook or tent and Syntagma”: understanding global resistance movements from Syntagma to Tahrir

This is an Accepted Manuscript of an article published by Taylor & Francis in Global Affairs on 9 May 2016, available online: http://www.tandfonline.com/10.1080/23340460.2016.1154350.This article proposes a conceptual guideline with the objective of understanding the political, economic and social complexities of contemporary street/square protests. It will be argued that contemporary protest movements can be understood from a conceptual perspective that effectively integrates individuals (their minds and bodies) and spaces to the approach of “multitude”. This guideline consists of three moves: conceptualizing individualistic dimension; space dimension; and collective dimension. In the first section, resisting individuals as cognitive and material beings with the acknowledgement of their multiple subjectivities will be discussed. As the second pillar of the movements, the relationship between resisting individuals and space of resistance will be unpacked. It will be highlighted that the contemporary resistance movements develop a novel relationship with the space they occupy by respatializing it as “home of resistance”. Finally, the multitude approach will be discussed in relation to the radical democratic approach in order to conceptualize the collective dimension of the movements

An Integrated Approach for a Structural and Functional Evaluation of Biosimilars: Implications for Erythropoietin

BACKGROUND: Authorization to market a biosimilar product by the appropriate institutions is expected based on biosimilarity with its originator product. The analogy between the originator and its biosimilar(s) is assessed through safety, purity, and potency analyses. OBJECTIVE: In this study, we proposed a useful quality control system for rapid and economic primary screening of potential biosimilar drugs. For this purpose, chemical and functional characterization of the originator rhEPO alfa and two of its biosimilars was discussed. METHODS: Qualitative and quantitative analyses of the originator rhEPO alfa and its biosimilars were performed using reversed-phase high-performance liquid chromatography (RP-HPLC). The identification of proteins and the separation of isoforms were studied using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF–MS) and two-dimensional gel electrophoresis (2D-PAGE), respectively. Furthermore, the biological activity of these drugs was measured both in vitro, evaluating the TF-1 cell proliferation rate, and in vivo, using the innovative experimental animal model of the zebrafish embryos. RESULTS: Chemical analyses showed that the quantitative concentrations of rhEPO alfa were in agreement with the labeled claims by the corresponding manufacturers. The qualitative analyses performed demonstrated that the three drugs were pure and that they had the same amino acid sequence. Chemical differences were found only at the level of isoforms containing N-glycosylation; however, functional in vitro and in vivo studies did not show any significant differences from a biosimilar point of view. CONCLUSION: These rapid and economic structural and functional analyses were effective in the evaluation of the biosimilarity between the originator rhEPO alfa and the biosimilars analyzed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40259-015-0136-3) contains supplementary material, which is available to authorized users

Advances in Management Accounting

Most theoretical and empirical studies on the capital structure of the firmfocus on public corporations. Only a limited number of studies on capitalstructure have been conducted on small-sized enterprises and, especially onsmall and growing high-tech firms. One of the most important events in theearly life-cycle of any enterprise with serious growth ambitions is the infusionof external capital (Reid, 1996). However, previous studies indicatethat small high-tech firms face certain problems when financing businessstart-ups (e.g. Cassar, 2004). In addition, the lack of collateral will be aproblem because of the limited tangible assets of high-tech firms. Sciencebasedand high-growth companies have limited tangible assets, high-riskand -growth potential because they invest heavily in intangibles, such asR&D, customer-base creation, franchise and brand development (Cassar,2004; Amir & Lev, 199

Relation Between Exertional Ischemia and Prognosis in Mildly Symptomatic Patients with Single or Double Vessel Coronary Artery Disease and Left Ventricular Dysfuntion at Rest

The randomized multicenter trials indicate that survival in patients with coronary artery disease and left ventricular dysfunction is enhanced by surgical therapy compared with medical therapy. This beneficial effect of coronary bypass surgery was demonstrated in patients with either three vessel or left main coronary artery disease, but not in those with one or two vessel disease. To determine whether subgroups of mildly symptomatic patients with one or two vessel coronary artery disease and left ventricular dysfunction have an increased risk of death or cardiac events during medical therapy, 53 consecutive patients with angiographically defined one or two vessel disease and impaired left ventricular function (ejection fraction 20% to 40%) were studied by exercise electrocardiography (ECG) and rest and exercise radionuclide angiography. All but two patients had previous myocardial infarction, and all were asymptomatic or only mildly symptomatic during medical therapy. By univariate life table analysis, mortality during medical therapy was associated significantly with the ST segment response to exercise (p 30%, the probability of survival at 6 years was 97 ± 3% (±SE) compared with a survival rate of 62± 14% in the remaining subjects (p < 0.005). Similarly, 6 year survival was 100% in patients whose ejection fraction increased from the value at rest but was only 74 ± 10% in the remaining patients (p < 0.005). Exercise capacity was not associated with survival. The likelihood of a cardiac event (death, reinfarction or congestive heart failure) during medical treatment was also associated significantly with the exercise ejection fraction and magnitude of change in ejection fraction with exercise (both p < 0.005). Twelve of the 18 events, including seven of the eight deaths, occurred in patients with two vessel disease. Therefore, noninvasive indexes of left ventricular function and myocardial ischemia are important predictors of the clinical course of mildly symptomatic patients with two vessel disease and left ventricular dysfunction at rest, and may be used to identify subgroups of patients at risk of death, as well as of major cardiac events, during subsequent medical therapy