Trace-Checking CPS Properties: Bridging the Cyber-Physical Gap

Cyber-physical systems combine software and physical components. Specification-driven trace-checking tools for CPS usually provide users with a specification language to express the requirements of interest, and an automatic procedure to check whether these requirements hold on the execution traces of a CPS. Although there exist several specification languages for CPS, they are often not sufficiently expressive to allow the specification of complex CPS properties related to the software and the physical components and their interactions. In this paper, we propose (i) the Hybrid Logic of Signals (HLS), a logic-based language that allows the specification of complex CPS requirements, and (ii) ThEodorE, an efficient SMT-based trace-checking procedure. This procedure reduces the problem of checking a CPS requirement over an execution trace, to checking the satisfiability of an SMT formula. We evaluated our contributions by using a representative industrial case study in the satellite domain. We assessed the expressiveness of HLS by considering 212 requirements of our case study. HLS could express all the 212 requirements. We also assessed the applicability of ThEodorE by running the trace-checking procedure for 747 trace-requirement combinations. ThEodorE was able to produce a verdict in 74.5% of the cases. Finally, we compared HLS and ThEodorE with other specification languages and trace-checking tools from the literature. Our results show that, from a practical standpoint, our approach offers a better trade-off between expressiveness and performance

Interventi archeologici in Uzbekistan

L'articolo presenta i risultati delle indagini preliminari condotte dalla missione archeologica a Samarcanda (Uzbekistan), trattando nello specifico: carta archeologica e censimento dei siti; lo scavo del sito altomedievale di Kafir Kala; lo studio del Dargom e del sistema d'irrigazion

Trace-Checking CPS Properties: Bridging the Cyber-Physical Gap

Cyber-physical systems combine software and physical components. Specification-driven trace-checking tools for CPS usually provide users with a specification language to express the requirements of interest, and an automatic procedure to check whether these requirements hold on the execution traces of a CPS. Although there exist several specification languages for CPS, they are often not sufficiently expressive to allow the specification of complex CPS properties related to the software and the physical components and their interactions. In this paper, we propose (i) the Hybrid Logic of Signals (HLS), a logic-based language that allows the specification of complex CPS requirements, and (ii) ThEodorE, an efficient SMT-based trace-checking procedure. This procedure reduces the problem of checking a CPS requirement over an execution trace, to checking the satisfiability of an SMT formula. We evaluated our contributions by using a representative industrial case study in the satellite domain. We assessed the expressiveness of HLS by considering 212 requirements of our case study. HLS could express all the 212 requirements. We also assessed the applicability of ThEodorE by running the trace-checking procedure for 747 trace-requirement combinations. ThEodorE was able to produce a verdict in 74.5% of the cases. Finally, we compared HLS and ThEodorE with other specification languages and trace-checking tools from the literature. Our results show that, from a practical standpoint, our approach offers a better trade-off between expressiveness and performance

ThEodorE: a Trace Checker for CPS Properties

ThEodorE is a trace checker for Cyber-Physical systems (CPS). It provides users with (i) a GUI editor for writing CPS requirements; (ii) an automatic procedure to check whether the requirements hold on execution traces of a CPS. ThEodorE enables writing requirements using the Hybrid Logic of Signals (HLS), a novel, logic-based specification language to express CPS requirements. The trace checking procedure of ThEodorE reduces the problem of checking if a requirement holds on an execution trace to a satisfiability problem, which can be solved using off-the-shelf Satisfiability Modulo Theories (SMT) solvers. This artifact paper presents the tool support provided by ThEodorE

Radiomics Analysis on [68Ga]Ga-PSMA-11 PET and MRI-ADC for the Prediction of Prostate Cancer ISUP Grades: Preliminary Results of the BIOPSTAGE Trial

Prostate cancer (PCa) risk categorization based on clinical/PSA testing results in a substantial number of men being overdiagnosed with indolent, early-stage PCa. Clinically non-significant PCa is characterized as the presence of ISUP grade one, where PCa is found in no more than two prostate biopsy cores.MRI-ADC and [68Ga]Ga-PSMA-11 PET have been proposed as tools to predict ISUP grade one patients and consequently reduce overdiagnosis. In this study, Radiomics analysis is applied to MRI-ADC and [68Ga]Ga-PSMA-11 PET maps to quantify tumor characteristics and predict histology-proven ISUP grades. ICC was applied with a threshold of 0.6 to assess the features’ stability with variations in contouring. Logistic regression predictive models based on imaging features were trained on 31 lesions to differentiate ISUP grade one patients from ISUP two+ patients. The best model based on [68Ga]Ga-PSMA-11 PET returned a prediction efficiency of 95% in the training phase and 100% in the test phase whereas the best model based on MRI-ADC had an efficiency of 100% in both phases. Employing both imaging modalities, prediction efficiency was 100% in the training phase and 93% in the test phase. Although our patient cohort was small, it was possible to assess that both imaging modalities add information to the prediction models and show promising results for further investigations

A Novel Benchmarking Approach to Assess the Agreement among Radiomic Tools

Background: The translation of radiomic models into clinical practice is hindered by the limited reproducibility of features across software and studies. Standardization is needed to accelerate this process and to bring radiomics closer to clinical deployment.Purpose: To assess the standardization level of seven radiomic software programs and investigate software agreement as a function of built-in image preprocessing (eg, interpolation and discretization), feature aggregation methods, and the morphological characteristics (ie, volume and shape) of the region of interest (ROI).Materials and Methods: The study was organized into two phases: In phase I, the two Image Biomarker Standardization Initiative (IBSI) phantoms were used to evaluate the IBSI compliance of seven software programs. In phase II, the reproducibility of all IBSI-standardized radiomic features across tools was assessed with two custom Italian multicenter Shared Understanding of Radiomic Extractors (ImSURE) digital phantoms that allowed, in conjunction with a systematic feature extraction, observations on whether and how feature matches between program pairs varied depending on the preprocessing steps, aggregation methods, and ROI characteristics.Results: In phase I, the software programs showed different levels of completeness (ie, the number of computable IBSI benchmark values). However, the IBSI-compliance assessment revealed that they were all standardized in terms of feature implementation. When considering additional preprocessing steps, for each individual program, match percentages fell by up to 30%. In phase II, the ImSURE phantoms showed that software agreement was dependent on discretization and aggregation as well as on ROI shape and volume factors.Conclusion: The agreement of radiomic software varied in relation to factors that had already been standardized (eg, interpolation and discretization methods) and factors that need standardization. Both dependences must be resolved to ensure the reproducibility of radiomic features and to pave the way toward the clinical adoption of radiomic models. Published under a CC BY 4.0 license

The potential role of MR based radiomic biomarkers in the characterization of focal testicular lesions

How to differentiate with MRI-based techniques testicular germ (TGCTs) and testicular non-germ cell tumors (TNGCTs) is still under debate and Radiomics may be the turning key. Our purpose is to investigate the performance of MRI-based Radiomics signatures for the preoperative prediction of testicular neoplasm histology. The aim is twofold: (i), differentiating TGCTs and TNGCTs status and (ii) differentiating seminomas (SGCTs) from non-seminomatous (NSGCTs). Forty-two patients with pathology-proven testicular neoplasms and referred for pre-treatment MRI, were retrospectively enrolled. Thirty-two out of 44 lesions were TGCTs. Twelve out of 44 were TNGCTs or other histologies. Two radiologists segmented the volume of interest on T2-weighted images. Approximately 500 imaging features were extracted. Least Absolute Shrinkage and Selection Operator (LASSO) was applied as method for variable selection. A linear model and a linear support vector machine (SVM) were trained with selected features to assess discrimination scores for the two endpoints. LASSO identified 3 features that were employed to build fivefold validated linear discriminant and linear SVM classifiers for the TGCT-TNGCT endpoint giving an overall accuracy of 89%. Four features were employed to build another SVM for the SGCT-SNGCT endpoint with an overall accuracy of 86%. The data obtained proved that T2-weighted-based Radiomics is a promising tool in the diagnostic workup of testicular neoplasms by discriminating germ cell from non-gem cell tumors, and seminomas from non-seminomas

Preliminary Retrospective Analysis of Daily Tomotherapy Output Constancy Checks Using Statistical Process Control - Fig 3

<p>A) Static and B) dynamic output EWMA charts. The datasets (#1, #2, #3 and #4) correspond to the same datasets shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0147936#pone.0147936.g002" target="_blank">Fig 2</a>.</p

MR Spectroscopy in Prostate Cancer: New Algorithms to Optimize Metabolite Quantification

<div><p>Prostate cancer (PCa) is the most common non-cutaneous cancer in male subjects and the second leading cause of cancer-related death in developed countries. The necessity of a non-invasive technique for the diagnosis of PCa in early stage has grown through years. Proton magnetic resonance spectroscopy (¹H-MRS) and proton magnetic resonance spectroscopy imaging (¹H-MRSI) are advanced magnetic resonance techniques that can mark the presence of metabolites such as citrate, choline, creatine and polyamines in a selected voxel, or in an array of voxels (in MRSI) inside prostatic tissue. Abundance or lack of these metabolites can discriminate between pathological and healthy tissue. Although the use of magnetic resonance spectroscopy (MRS) is well established in brain and liver with dedicated software for spectral analysis, quantification of metabolites in prostate can be very difficult to achieve, due to poor signal to noise ratio and strong <i>J-</i>coupling of the citrate. The aim of this work is to develop a software prototype for automatic quantification of citrate, choline and creatine in prostate. Its core is an original fitting routine that makes use of a fixed step gradient descent minimization algorithm (FSGD) and MRS simulations developed with the GAMMA libraries in C++. The accurate simulation of the citrate spin systems allows to predict the correct <i>J</i>-modulation under different NMR sequences and under different coupling parameters. The accuracy of the quantifications was tested on measurements performed on a Philips Ingenia 3T scanner using homemade phantoms. Some acquisitions in healthy volunteers have been also carried out to test the software performance <i>in vivo</i>.</p></div