316 research outputs found

    Access to Environmental Justice: NGO Environmental Advocacy on Mining-Related Environmental Issues in Mongolia

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    In this thesis, I apply the theory of environmental justice to determine how NGOs use substantive and procedural environmental rights to advocate for mining-affected nomadic communities in Mongolia. Environmental NGOs often possess legal and scientific expertise pertinent to resolving and mitigating environmental risks and demanding justice for environmental damages on behalf of the mining-affected local communities. Based on the environmental justice theories, I have constructed a theoretical framework to examine how NGOs access and implement environmental justice tools, both domestically and internationally. Using a multi-methods research approach, including documentary analysis and qualitative interviews with NGO experts and lawyers, I was able to uncover the experiences, difficulties, and challenges faced by NGOs as they seek favorable environmental outcomes. My findings demonstrate that domestic and international environmental justice tools provided opportunities to NGOs to litigate, advocate, negotiate, and mediate the disputes between marginalized mining-affected nomadic communities and their much-larger opponents, mining companies

    The identification and classification of endogenous retroviruses in the horse genome

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    Endogenous retroviruses (ERVs) are sequences that derived from ancient retroviral infections of germ cells and integrated in humans, mammals and other vertebrates millions years ago. These ERVs are inherited according to Mendelian expectations in the same way as all other genes in the genome. Size of complete endogenous retrovirus is between 8-12 kb long in average and contains gag, pro, pol and env genes that always occur in the same order. Coding sequences are flanked by two LTRs (Long Terminal Repeat sequences). Most ERVs are defective that are carrying multitude of inactivating mutations. However some ERVs still have open reading frames in their genome. These ERVs settle close to functional genes or within the genes and can influence or control functions of the host genes using their LTRs. Most integration has deleterious effects. However some integration could be example of positive co-adaptation as syncitin which is involved to form the syncytial layer of the placenta. The first equine endogenous beta retrovirus which is EcERV-Beta1 has been found in 2011 by Antoinette C. van der Kuyl1. The first known beta retrovirus and few pol gene similar to foamy retrovirus were only known endogenous retroviruses fixed in the domestic horse (Equus caballus) genome. Our aim of the study was to identify other endogenous retrovirus sequences in an equine genome and classify them into groups. Based on the high number of SINEs (Equine Repetitive Element) in the horse genome we hypothesized that certain ERVs will be located sufficiently close to SINEs that they will be amplified using an unbiased SINE-PCR approach with degenerate primers. The nearest SINE element was located 5.5 k bp upstream at the 5’of the EcERV-Beta1. Pan-pol PCR was also used to find novel ERVs based on 640 bp long region of pol gene which is the most conserved region of ERVs. 27 complete and novel ERVs that are 13 beta, 13 gamma, 1 spuma and 249 candidate endogenous retroviruses have been revealed using LTR_STRUC tool and double checked by Retrotector© online tool and NCBI-BLAST tool. It was proven that EcERV-Beta1 which has 2 LTRs with 1% divergence between LTRs has a polymorphism among 13 different breeds

    Борьба Монголии за независимость (1900–1921 гг.) и становление политической системы страны

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    The article touches upon the national liberation struggle of Mongolia to the independence from China and shaping of political system of the state. The author examines the role of Russia in Mongolia’s liberation from Chinese supremacy.В статье анализируется национально-освободительная борьба Монголии за независимость от Китая и формирование политической системы страны. Автор также рассматриваетроль России в освобождении Монголии от китайского господства

    Impact of Enterprise Risk Management on the Performance of the Publicly Listed Companies on London Stock Exchange

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    This dissertation studies the relationship between the implementation of Enterprise Risk Management (ERM) and Business and Market performance of listed companies in London Stock Exchange from 2012 to 2018. Based on the selected sample, it is found that the implementation of ERM does not increase shareholders value, instead it has a negative impact on business performance. Particularly, the presence of Chief Risk Officer, size of Risk Committee, the number of non-executive directors had negative effect on ROA for the whole sample. Therefore, this study provides further investigation by classifying sample as financial and non-financial industry. Therefore, more negative effects found in financial industry and no evidence of relationship found in non-financial industry. However, there was no statistically significant relationship found between ERM implementation and market performance. This dissertation makes contribution to the empirical evidences on ERM studies. The findings raises a question whether the ERM is truly implemented in the UK during the reported period or companies claim to have implemented ERM as it is becoming more and more common method. This demonstrates a necessity for further research on this topic

    KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family

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    13301甲第4079号博士(医学)金沢大学博士論文要旨Abstract 以下に掲載:Cell Cycle 12(13) pp.2100-2112 2013. Landes Bioscience. 共著者:Zanabazar Enkhbaatar, Minoru Terashima, Dulamsuren Oktyabri, Shoichiro Tange, Akihiko Ishimura, Seiji Yano, Takeshi Suzuk
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